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Protein

Matrix metalloproteinase

Gene

Mmp27

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiM10.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:Mmp27Imported
Synonyms:Mmp27_predictedImported
ORF Names:rCG_31882Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1306642. Mmp27.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17UniRule annotationAdd BLAST17
ChainiPRO_501075366018 – 511Matrix metalloproteinaseUniRule annotationAdd BLAST494

Keywords - PTMi

Disulfide bondSAAS annotation, ZymogenUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000040208.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058603.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 263ZnMcInterPro annotationAdd BLAST162
Repeati283 – 326HemopexinPROSITE-ProRule annotationAdd BLAST44
Repeati327 – 372HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati374 – 422HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati423 – 466HemopexinPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.
KOiK08005.
OMAiPHACDPD.
OrthoDBiEOG091G03DP.
TreeFamiTF315428.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 2 hits.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR028732. MMP27.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
PANTHERiPTHR10201:SF171. PTHR10201:SF171. 1 hit.
PfamiView protein in Pfam
PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.

Sequencei

Sequence statusi: Complete.

D3ZQ07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCLLPLMVN FITLSSAFLP DRKDKNEENN QLAQAYLNQF YSLEIEGSHL
60 70 80 90 100
VQSKNRSLLD GKLQEMQAFF GLTVTGKLDS DTLEIMKVPR CGVPDVGQYG
110 120 130 140 150
YTLPGWRKYN LTYRIMNYTP DMTHADVDEA IQKALQVWSK VTPLMFTRIS
160 170 180 190 200
KGVADIMIAF RTRVHGWCPR HFDGPLGVLG HAFPPGLGLG GDTHFDEDET
210 220 230 240 250
WTTGDGEGFN LFLVAAHEFG HSLGLSHSSD QTALMFPNYV SLDPNKYPLS
260 270 280 290 300
QDDINGIQSI YGSPSKVPTK PNGNPVPCAC EPNLTFDAVT TFRREIMFLK
310 320 330 340 350
GRHLWRVYSD ITGAEFEFID SFWPSLPADL QAAYESPRDE VLVFKDENFW
360 370 380 390 400
VIRGNSVLPG YPKSIHTLGF PRRVKKIDAA VCDHDTKKTF FFVGIWCWRY
410 420 430 440 450
DEMAQAMDRG FPQRIMKRFP GIRLRVDAVF QRNGFFYFFR GSRQFEYDMK
460 470 480 490 500
AKNITQVMKT NTWFLCNEPL NSSSNVSVEG KAHSIGTVIF HHKSASLLSF
510
SIVHVLTKAY S
Length:511
Mass (Da):58,054
Last modified:April 20, 2010 - v1
Checksum:iF437C8F386AF0D86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069020 Genomic DNA. No translation available.
CH473993 Genomic DNA. Translation: EDL78529.1.
RefSeqiNP_001100269.1. NM_001106799.1.
UniGeneiRn.218678.

Genome annotation databases

EnsembliENSRNOT00000061887; ENSRNOP00000058603; ENSRNOG00000040208.
GeneIDi300340.
KEGGirno:300340.
UCSCiRGD:1306642. rat.

Similar proteinsi

Entry informationi

Entry nameiD3ZQ07_RAT
AccessioniPrimary (citable) accession number: D3ZQ07
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: August 30, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported