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Protein

Plexin-A3

Gene

Plxna3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-399954. Sema3A PAK dependent Axon repulsion.
R-RNO-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-RNO-399956. CRMPs in Sema3A signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A3
Gene namesi
Name:Plxna3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1584973. Plxna3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 12201201ExtracellularSequence analysisAdd
BLAST
Transmembranei1221 – 124121HelicalSequence analysisAdd
BLAST
Topological domaini1242 – 1872631CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 18721853Plexin-A3PRO_0000411105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Disulfide bondi78 ↔ 87PROSITE-ProRule annotation
Disulfide bondi113 ↔ 121PROSITE-ProRule annotation
Disulfide bondi267 ↔ 388PROSITE-ProRule annotation
Disulfide bondi283 ↔ 339PROSITE-ProRule annotation
Disulfide bondi357 ↔ 376PROSITE-ProRule annotation
Disulfide bondi492 ↔ 509PROSITE-ProRule annotation
Disulfide bondi498 ↔ 540PROSITE-ProRule annotation
Disulfide bondi501 ↔ 518PROSITE-ProRule annotation
Disulfide bondi512 ↔ 524PROSITE-ProRule annotation
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence analysis
Disulfide bondi575 ↔ 595PROSITE-ProRule annotation
Glycosylationi1163 – 11631N-linked (GlcNAc...)Sequence analysis
Modified residuei1597 – 15971PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiD3ZPX4.
PeptideAtlasiD3ZPX4.
PRIDEiD3ZPX4.

PTM databases

iPTMnetiD3ZPX4.

Expressioni

Gene expression databases

GenevisibleiD3ZPX4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053147.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 489470SemaPROSITE-ProRule annotationAdd
BLAST
Domaini841 – 93494IPT/TIG 1Add
BLAST
Domaini936 – 102186IPT/TIG 2Add
BLAST
Domaini1024 – 1123100IPT/TIG 3Add
BLAST
Domaini1126 – 121287IPT/TIG 4Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1240 – 129455Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 4 IPT/TIG domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
InParanoidiD3ZPX4.
KOiK06820.
OMAiGVMQPLT.
OrthoDBiEOG7Q8CM9.
PhylomeDBiD3ZPX4.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZPX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA
60 70 80 90 100
VNRVFKLASN LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL
110 120 130 140 150
LLIDYAARRL VACGSIWQGI CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD
160 170 180 190 200
SMAGVIVEQG QGPSKLFVGT AVDGKSEYFP TLSSRKLIDD EDSGDMFSLV
210 220 230 240 250
YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL TLQLDTQQTL
260 270 280 290 300
LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK
310 320 330 340 350
PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI
360 370 380 390 400
RRRIQSCYRG EGTLALPWLL NKELPCINTP MQINGNFCGL VLNQPLGGLH
410 420 430 440 450
VIEGLPLLAD STDGMASVAA YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ
460 470 480 490 500
LYETVSVVQG TPILRDLLFS PDHRHIYLLS EKQVSQLPVE TCEQYLSCAA
510 520 530 540 550
CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELNKC IQVRVRPNNV
560 570 580 590 600
SVTSSGVQLT VAMRNVPDLS LGVSCSFEEV TESEAILLPS GELRCPSPSL
610 620 630 640 650
QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG
660 670 680 690 700
SPYPCHWCKY RHVCTSHPHE CSFQEGRVHS PEGCPEILPR GDLLIPVGVM
710 720 730 740 750
QPLTLRAKNL PQPQSGQKNY ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY
760 770 780 790 800
FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF RALLYKCWAQ RPSCGLCLKA
810 820 830 840 850
DPRFNCGWCI SEHRCQLRVH CPAPKSNWMH PSQKGARCSH PRITQIHPLT
860 870 880 890 900
GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME
910 920 930 940 950
ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTLDR VSPTRGPASG
960 970 980 990 1000
GTRLTISGTS LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PISTLGPSQA
1010 1020 1030 1040 1050
PIILAIDHAN ISSTGVIYTY TQDPTVTHLE PTWSIINGST SITVSGTHLL
1060 1070 1080 1090 1100
TVQEPRVRAK YRGIETTNTC QVINDTAMLC KAPGIFLGHP QPRAQGEHPD
1110 1120 1130 1140 1150
EFGFLLDHVQ AARSLNRSSF TYYPDPSFEP LGPSGVLDVK PGSHVVLKGK
1160 1170 1180 1190 1200
NLIPAAAGSS RLNYTVLIGG QPCALTVSDT QLLCDSPSQT GRQPVMVLVG
1210 1220 1230 1240 1250
GLEFWLGTLH ITADRALTLP AMVGLAAGGG LLLLAITVVL VAYKRKTQDA
1260 1270 1280 1290 1300
DRTLKRLQLQ MDNLESRVAL ECKEAFAELQ TDINELTNHM DGVQIPFLDY
1310 1320 1330 1340 1350
RTYAVRVLFP GIEAHPVLKE LDTPPNVEKA LRLFGQLLHS RAFLLTFIHT
1360 1370 1380 1390 1400
LEAQSSFSMR DRGTVASLTM VALQSRLDYA TGLLKQLLAD LIEKNLESKN
1410 1420 1430 1440 1450
HPKLLLRRTE SVAEKMLTNW FTFLLHKFLK ECAGEPLFLL YCAIKQQMEK
1460 1470 1480 1490 1500
GPIDAITGEA RYSLSEDKLI RQQIDYKTLT LHCVCPESEG SAQVPVKVLN
1510 1520 1530 1540 1550
CDSITQAKDK LLDTVYKGIP YSQRPKAEDM DLEWRQGRMA RIILQDEDIT
1560 1570 1580 1590 1600
TKIECDWKRI NSLAHYQVTD GSLVALVPKQ VSAYNMANSF TFTRSLSRYE
1610 1620 1630 1640 1650
SLLRAASSPD SLRSRAPMLT PDQEAGTKLW HLVKNHDHAD HREGDRGSKM
1660 1670 1680 1690 1700
VSEIYLTRLL ATKGTLQKFV DDLFETVFST AHRGSALPLA IKYMFDFLDE
1710 1720 1730 1740 1750
QADQRQISDP DVRHTWKSNC LPLRFWVNVI KNPQFVFDIH KNSITDACLS
1760 1770 1780 1790 1800
VVAQTFMDSC STSEHRLGKD SPSNKLLYAK DIPNYKSWVE RYYRDIAKMA
1810 1820 1830 1840 1850
SISDQDMDAY LVEQSRLHAN DFNVLSALSE LYFYVTKYRQ EILTSLDRDA
1860 1870
SCRKHKLRQK LEQIITLVSS SS
Length:1,872
Mass (Da):207,982
Last modified:April 20, 2010 - v1
Checksum:iD8DACA874717E870
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094668 Genomic DNA. No translation available.
CH474099 Genomic DNA. Translation: EDL84973.1.
RefSeqiNP_001101051.2. NM_001107581.2.
XP_006229639.1. XM_006229577.2.
XP_006229640.1. XM_006229578.2.
UniGeneiRn.21101.

Genome annotation databases

EnsembliENSRNOT00000083148; ENSRNOP00000068735; ENSRNOG00000060464.
GeneIDi309280.
KEGGirno:309280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094668 Genomic DNA. No translation available.
CH474099 Genomic DNA. Translation: EDL84973.1.
RefSeqiNP_001101051.2. NM_001107581.2.
XP_006229639.1. XM_006229577.2.
XP_006229640.1. XM_006229578.2.
UniGeneiRn.21101.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053147.

PTM databases

iPTMnetiD3ZPX4.

Proteomic databases

PaxDbiD3ZPX4.
PeptideAtlasiD3ZPX4.
PRIDEiD3ZPX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083148; ENSRNOP00000068735; ENSRNOG00000060464.
GeneIDi309280.
KEGGirno:309280.

Organism-specific databases

CTDi55558.
RGDi1584973. Plxna3.

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
InParanoidiD3ZPX4.
KOiK06820.
OMAiGVMQPLT.
OrthoDBiEOG7Q8CM9.
PhylomeDBiD3ZPX4.
TreeFamiTF312962.

Enzyme and pathway databases

ReactomeiR-RNO-399954. Sema3A PAK dependent Axon repulsion.
R-RNO-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-RNO-399956. CRMPs in Sema3A signaling.

Miscellaneous databases

PROiD3ZPX4.

Gene expression databases

GenevisibleiD3ZPX4. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiPLXA3_RAT
AccessioniPrimary (citable) accession number: D3ZPX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 20, 2010
Last modified: July 6, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.