ID   D3ZN38_RAT              Unreviewed;       213 AA.
AC   D3ZN38;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   SubName: Full=StAR-related lipid transfer domain containing 5 {ECO:0000313|Ensembl:ENSRNOP00000015320.3};
GN   Name=Stard5 {ECO:0000313|Ensembl:ENSRNOP00000015320.3,
GN   ECO:0000313|RGD:1561783};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000015320.3, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000015320.3, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000015320.3,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000015320.3}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000015320.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in the intracellular transport of sterols or
CC       other lipids. May bind cholesterol or other sterols.
CC       {ECO:0000256|ARBA:ARBA00024750}.
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DR   RefSeq; NP_001178940.1; NM_001192011.1.
DR   AlphaFoldDB; D3ZN38; -.
DR   SMR; D3ZN38; -.
DR   IntAct; D3ZN38; 2.
DR   STRING; 10116.ENSRNOP00000015320; -.
DR   PhosphoSitePlus; D3ZN38; -.
DR   PaxDb; 10116-ENSRNOP00000015320; -.
DR   Ensembl; ENSRNOT00000015320.6; ENSRNOP00000015320.3; ENSRNOG00000025052.5.
DR   GeneID; 502348; -.
DR   KEGG; rno:502348; -.
DR   UCSC; RGD:1561783; rat.
DR   AGR; RGD:1561783; -.
DR   CTD; 80765; -.
DR   RGD; 1561783; Stard5.
DR   eggNOG; KOG3845; Eukaryota.
DR   GeneTree; ENSGT00940000159159; -.
DR   HOGENOM; CLU_093200_1_0_1; -.
DR   OMA; GCPPQSG; -.
DR   OrthoDB; 2872322at2759; -.
DR   Reactome; R-RNO-159418; Recycling of bile acids and salts.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000025052; Expressed in liver and 19 other cell types or tissues.
DR   GO; GO:0015485; F:cholesterol binding; ISO:RGD.
DR   GO; GO:0120020; F:cholesterol transfer activity; ISO:RGD.
DR   GO; GO:0070508; P:cholesterol import; ISO:RGD.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR000799; StAR-like.
DR   InterPro; IPR043556; StARD5/6.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR46374; PROTEIN CBG07384; 1.
DR   PANTHER; PTHR46374:SF3; STAR-RELATED LIPID TRANSFER PROTEIN 5; 1.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   SMART; SM00234; START; 1.
DR   SUPFAM; SSF55961; Bet v1-like; 1.
DR   PROSITE; PS50848; START; 1.
PE   4: Predicted;
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ   SEQUENCE   213 AA;  23955 MW;  E8D10102D99AFDCD CRC64;
     MDLSWATQES EAVAEKVLRY RRDASGWKKC REGNGVSISW RPSEEFPGNL YRGEGILCGT
     PEEVWDCVKP VAGGLREKWD DNVNSFEIVQ SITDTLCVSR TSTPSAAMKL ISPRDFVDLV
     LVKKYEDGTI SSNATHVEHP LCPPKPGFVR GFNHPCGCFC EPLPGEPNKT HLVTFFQTDL
     NGYLPQSVVD SFFPRSMAEF YPNLQKAVRK FHH
//