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Protein
Submitted name:

Integrin subunit alpha 4

Gene

Itga4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: RGD
  • cell adhesion molecule binding Source: RGD
  • C-X3-C chemokine binding Source: Ensembl
  • fibronectin binding Source: RGD
  • protein antigen binding Source: RGD

GO - Biological processi

  • blood vessel remodeling Source: RGD
  • cell adhesion Source: RGD
  • cell-matrix adhesion Source: RGD
  • cell-matrix adhesion involved in ameboidal cell migration Source: RGD
  • cell migration Source: RGD
  • cellular response to cytokine stimulus Source: RGD
  • chorio-allantoic fusion Source: RGD
  • clathrin-dependent extracellular exosome endocytosis Source: RGD
  • diapedesis Source: RGD
  • endodermal cell differentiation Source: RGD
  • face development Source: RGD
  • heart development Source: RGD
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: RGD
  • heterotypic cell-cell adhesion Source: RGD
  • import into cell Source: RGD
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • leukocyte cell-cell adhesion Source: RGD
  • leukocyte tethering or rolling Source: RGD
  • negative regulation of protein homodimerization activity Source: RGD
  • positive regulation of leukocyte cell-cell adhesion Source: RGD
  • positive regulation of leukocyte migration Source: RGD
  • positive regulation of leukocyte tethering or rolling Source: RGD
  • positive regulation of T cell migration Source: RGD
  • receptor clustering Source: RGD
  • substrate adhesion-dependent cell spreading Source: RGD
  • T cell migration Source: RGD

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin subunit alpha 4Imported
Gene namesi
Name:Itga4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1593249. Itga4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei980 – 1004HelicalUniRule annotationAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiD3ZMQ3.
PeptideAtlasiD3ZMQ3.
PRIDEiD3ZMQ3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004861.

Interactioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: RGD
  • C-X3-C chemokine binding Source: Ensembl
  • fibronectin binding Source: RGD
  • protein antigen binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006880.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 104FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati114 – 181FG-GAPPROSITE-ProRule annotationAdd BLAST68
Repeati189 – 241FG-GAPPROSITE-ProRule annotationAdd BLAST53
Repeati243 – 295FG-GAPPROSITE-ProRule annotationAdd BLAST53
Repeati296 – 355FG-GAPPROSITE-ProRule annotationAdd BLAST60
Repeati359 – 416FG-GAPPROSITE-ProRule annotationAdd BLAST58
Repeati420 – 482FG-GAPPROSITE-ProRule annotationAdd BLAST63
Domaini467 – 867Integrin_alpha2InterPro annotationAdd BLAST401

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPAV. Eukaryota.
ENOG410ZUFU. LUCA.
GeneTreeiENSGT00760000118782.
InParanoidiD3ZMQ3.
OMAiNRRDSWS.
OrthoDBiEOG091G011V.

Family and domain databases

InterProiView protein in InterPro
IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom_sf.
PfamiView protein in Pfam
PF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PRINTSiPR01185. INTEGRINA.
SMARTiView protein in SMART
SM00191. Int_alpha. 6 hits.
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiView protein in PROSITE
PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZMQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEAMCRPR PRGVALQEAV MLLLYFGVHF RVPTGHSYNL DPESALLYQG
60 70 80 90 100
PSGTLFGYSV VLHSHGTKRW LIVGAPTASW LANASVVNPG AIYRCRIGKN
110 120 130 140 150
PNQICEQLQL GSPSGEPCGK TCLEERDNQW LGVTISRQPG ENGSIVTCGH
160 170 180 190 200
RWKNIFYMKN NNKLPTGVCY GMPSDLRTEL SKRMAPCYQD FVRKFGENFA
210 220 230 240 250
SCQAGISSFY TQDLIVMGAP GSSYWTGSVF VYNITTNKYK AFVDRQNQVK
260 270 280 290 300
FGSYLGYSVG AGHFRNPHTT EVVGGAPQHE QIGKAYIFSI DESELTIVYE
310 320 330 340 350
MKGKKLGSYF GASVCAVDLN ADGFSDLLVG APMQSTIREE GRVFVYINSG
360 370 380 390 400
MGAVMVEMER VLVGSDKYAA RFGESMANLG DIDNDGFEDI AIGAPQEDDL
410 420 430 440 450
RGAVYIYNGR VDGISSTYSQ RIEGRQISQS LRMFGQSISG QIDADNNGYV
460 470 480 490 500
DVAVGAFQSD SAVLLRTRPV VIVEASLSHP ESVNRTKFDC TENGLLSVCV
510 520 530 540 550
DLKLCFSYKG KEVPGYIVLF YNVSLDVHRK AESPSRFYFF SNGTSDMITR
560 570 580 590 600
SIRVSSSGEK CRTHQAFMRK DVRDILTPIQ VEATYHLGHH VITKRNTEEF
610 620 630 640 650
PPLQPILQQK KEKDIIRKTI NFARFCAYEN CSADLQVSAK VGFLKPYENK
660 670 680 690 700
TYLAVGSMKT IMLNVSLFNA GDDAYETTLN VQLPTGLYFI KILDLEEKQI
710 720 730 740 750
NCDVTESSGV VKLACSLGYI YVDRLSRIDI SFLLDVSSLS RAHEDLSINV
760 770 780 790 800
HASCENEGKL DQVKDNRVTL VIPLRYEVML AVHGFVTPTS FVYGSSEENE
810 820 830 840 850
PEMCMAEKLN LTFHVINTGI SMAPNVSVKI MVPNSFLPRN DKLFNVLDVQ
860 870 880 890 900
ATMGQCQFEH YGRECALAQQ KGIAGTLTDL VKFLSKTDKR LLYCMKADRH
910 920 930 940 950
CLDFLCNFGK MESGKEASVH IQLEGRPSIL EMDETSSLKF EIKATAFPEP
960 970 980 990 1000
HPKVIELNKD ENIAHVYLEG LHHQRPKRHF TIVIVTISLL LGLIVLLLIS
1010 1020 1030
CVMWKAGFFK RQYKSILQEE NRRDSWSYVN SKSNDD
Length:1,036
Mass (Da):115,592
Last modified:April 20, 2010 - v1
Checksum:i1276013534A347DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07052610 Genomic DNA. No translation available.
RefSeqiXP_017447193.1. XM_017591704.1.
UniGeneiRn.12704.

Genome annotation databases

EnsembliENSRNOT00000006880; ENSRNOP00000006880; ENSRNOG00000004861.
GeneIDi311144.

Similar proteinsi

Entry informationi

Entry nameiD3ZMQ3_RAT
AccessioniPrimary (citable) accession number: D3ZMQ3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 22, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported