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Protein
Submitted name:

ADAM metallopeptidase with thrombospondin type 1 motif, 16

Gene

Adamts16

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi430Zinc; catalyticPROSITE-ProRule annotation1
Active sitei431PROSITE-ProRule annotation1
Metal bindingi434Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi440Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • branching involved in ureteric bud morphogenesis Source: Ensembl
  • male gamete generation Source: RGD
  • regulation of cilium assembly Source: RGD
  • regulation of systemic arterial blood pressure Source: RGD

Keywordsi

LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Submitted name:
ADAM metallopeptidase with thrombospondin type 1 motif, 16Imported
Gene namesi
Name:Adamts16Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310046 Adamts16

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500305269021 – 1221Sequence analysisAdd BLAST1201

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiD3ZLL7

Expressioni

Gene expression databases

BgeeiENSRNOG00000016812

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 492Peptidase M12BInterPro annotationAdd BLAST206
Domaini1183 – 1220PLACInterPro annotationAdd BLAST38

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00900000140815
InParanoidiD3ZLL7
KOiK08630
OMAiKKLQWLV
OrthoDBiEOG091G14M8
TreeFamiTF313537

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF08686 PLAC, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 5 hits

Sequencei

Sequence statusi: Complete.

D3ZLL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRGCFALW VLLLAQLSEQ QTPACALGAA AAATERLGDP HPPSSSGSDW
60 70 80 90 100
LETSEYDLVS AYEVDHSGDY VSYDIMHHQR RRRRAVTQSK GDALHLRLKG
110 120 130 140 150
PRHDLHLDLK AASNLMAPGF MVQTLGKGGT KSVQMFPAEE NCFYQGSLRS
160 170 180 190 200
QGNSSVALST CQGLLGMIRT KDADYFLKPL PPQLTSKLNR SAQGGSPSHI
210 220 230 240 250
LYKRSTEHQA PRENEVLMIT RKRDLARTHL HHDNFHLGLS RKQHFCGRRK
260 270 280 290 300
KYMPQPPDDN LYILPDEYKP SSRPKRSLLK SHRNEELNVE TLVVVDRKML
310 320 330 340 350
QSHGHENITT YVLTILNMVS ALFKDGTIGG NINIVIVGLI LLEDEQPGLA
360 370 380 390 400
ISHHADRTLT SFCQWQSGLM GKDGARHDHA ILLTGLDICS WKNEPCDTLG
410 420 430 440 450
FAPISGMCSK YRSCTVNEDS GLGLAFTIAH ESGHNFGMVH DGEGNMCKKS
460 470 480 490 500
EGNIMSPTLA GRNGVFSWSS CSRQYLHKFL STAQAICLAD QPKPVKEYKY
510 520 530 540 550
PEKLPGQLYD ANTQCKWQFG EKAKLCMLDF RKDICKALWC HRIGRKCETK
560 570 580 590 600
FMPAAEGTLC GQDMWCRGGQ CVKYGDEGPK PTHGHWSDWS PWSPCSRTCG
610 620 630 640 650
GGVSHRDRLC TNPRPSHGGK FCQGSARTLK LCNSQKCPLD SVGFRAAQCA
660 670 680 690 700
EYNSKRFRGW LYKWTPYTQV EDQDLCKLYC IAEGFDFFFS LSNKVKDGTP
710 720 730 740 750
CSEDSRNVCI DGMCEKVGCD NVLGSDATED SCGVCQGNNS DCVMHRGLYS
760 770 780 790 800
KNHPTNQYYH VVTIPSGARS IHIYETNIST SYISVRNSVK KYYLNGHWSV
810 820 830 840 850
DWPGRYKFSG TTFNYRRSYK EPESLTSTGP TNETLIVELL FQGRNPGVAW
860 870 880 890 900
EFSVPRSGSK RTPPPQPSYS WAILRSECSV SCGGGKMSSK AGCYRDLKVL
910 920 930 940 950
VNASFCNPKT RPVPALVPCK VSACPPSWSV GNWSTCSRTC GGGTQSRPVH
960 970 980 990 1000
CTRRAHYREE SISASLCPQP APPLHQACNS QSCPPAWSTG PWAECSRTCG
1010 1020 1030 1040 1050
KGWRKRTVAC KSTNPSARAQ LLHDTACTSE PKPRTHQVCL LKRCHKHKKL
1060 1070 1080 1090 1100
QWLVSAWSPC SATCQRGTQH RVLRCAEKYV SGKYRELASK KCLHLPKPDL
1110 1120 1130 1140 1150
ELERACGLIP CPKHPPYAAS GPPRGSWFAS PWSLCTASCG GGVQRRTVQC
1160 1170 1180 1190 1200
LLGGQPASDC FLHEKPETST ACNTHFCPIA EKRDTFCRDL FHWCYLVPQH
1210 1220
GMCSHRFYSK QCCNTCSKSN L
Length:1,221
Mass (Da):135,928
Last modified:July 22, 2015 - v3
Checksum:i8F961229697B9C01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07001035 Genomic DNA No translation available.
AABR07001036 Genomic DNA No translation available.
AABR07001037 Genomic DNA No translation available.
AABR07001038 Genomic DNA No translation available.
AABR07001039 Genomic DNA No translation available.
RefSeqiXP_003748732.1, XM_003748684.4
XP_003753205.1, XM_003753157.4

Genome annotation databases

EnsembliENSRNOT00000022790; ENSRNOP00000022790; ENSRNOG00000016812
GeneIDi306664
KEGGirno:306664

Similar proteinsi

Entry informationi

Entry nameiD3ZLL7_RAT
AccessioniPrimary (citable) accession number: D3ZLL7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: May 23, 2018
This is version 68 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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