ID   D3ZLC3_RAT              Unreviewed;      1255 AA.
AC   D3ZLC3;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   SubName: Full=ITPR interacting domain containing 2 {ECO:0000313|Ensembl:ENSRNOP00000008046.5};
GN   Name=Itprid2 {ECO:0000313|Ensembl:ENSRNOP00000008046.5,
GN   ECO:0000313|RGD:1310767}; Synonyms=Ssfa2 {ECO:0000313|RGD:1310767};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000008046.5, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000008046.5, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000008046.5,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0007829|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000008046.5}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000008046.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; NP_001101208.1; NM_001107738.1.
DR   AlphaFoldDB; D3ZLC3; -.
DR   STRING; 10116.ENSRNOP00000008046; -.
DR   PaxDb; 10116-ENSRNOP00000008046; -.
DR   Ensembl; ENSRNOT00000008046.7; ENSRNOP00000008046.5; ENSRNOG00000005865.8.
DR   GeneID; 311146; -.
DR   KEGG; rno:311146; -.
DR   AGR; RGD:1310767; -.
DR   CTD; 6744; -.
DR   RGD; 1310767; Itprid2.
DR   eggNOG; ENOG502QSG8; Eukaryota.
DR   GeneTree; ENSGT00940000158532; -.
DR   HOGENOM; CLU_007016_0_0_1; -.
DR   OMA; QHSNPDF; -.
DR   OrthoDB; 5311937at2759; -.
DR   TreeFam; TF331566; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000005865; Expressed in jejunum and 18 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0051015; F:actin filament binding; ISO:RGD.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   InterPro; IPR029325; ITPR-bd.
DR   InterPro; IPR029326; SSFA2_C.
DR   InterPro; IPR043444; TESPA1-like.
DR   PANTHER; PTHR17469:SF11; PROTEIN ITPRID2; 1.
DR   PANTHER; PTHR17469; SPERM SPECIFIC ANTIGEN 2-RELATED; 1.
DR   Pfam; PF14722; KRAP_IP3R_bind; 1.
DR   Pfam; PF14723; SSFA2_C; 1.
DR   SMART; SM01257; KRAP_IP3R_bind; 1.
PE   1: Evidence at protein level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ   SEQUENCE   1255 AA;  137191 MW;  03409140A92B915B CRC64;
     MNRPLSAEAE EELEWQVASR RRKAWAKCRS SWQASETEDL STETTTQDED EDDEEDLPGA
     KLPAAAGRGN VPNEKIAIWL KDCRTPLGAS LDEQSSVGPK GVLLRNGGSF EDDLSLGAEA
     NHLHEPDAQV ENCNNILAKE RRLQFHQKGR SMNSTGSGKS SGTVSSVSEL LELYEEDPEE
     ILYNLGFGRD EPDIASKIPS RFFNSSSFAR GIDIKVFLSA QMQRMEVENP NYALTSRFRQ
     IEVLTTVANA FSSLYSQVSG TPLQRIGSMS SVTSTKEAAD CPPPLTRSNT ANRLMKTLSK
     LNLCVDKTEK AEGSSTPAAE KGRSLSVSLS EDGGGGKSDP KPQKVIKKKE SSSMLATVTE
     EVSGSSSTIT DSIDADRLSD EAESNISHKV ESEENGEAHS QNDALRQSAV TDPDFGHDGG
     SMSSLCELES SSELKSAQAS SSEKEPCATL TIPSIRNIMV QQKDSFEMEE VQSTEGEAPH
     VPATCQLSLA KSKRDHLLRT ASQHSDSSGF AEDSTDCLSL NHLQVHESLQ AMGSSADSCD
     SETTVTSLGE DHVTPTAPDQ PYFNESEEES LASLQKGRAK VIVAEKRKAD NQDFPHCATA
     ENAGNNESVK GPCEPGPQIT ETETEEEPPL AATGELLREG SGESDMDKGS ECEFAQYTTH
     HILRSLTSFE EAQGSGMSSK KKTEFPSSVD RVNTALQRAQ MKVCSMSGQR VGRSLIKSKD
     LLKQRYFLAK AGYPLRRSQS LPTTLLSPVR VVSSVNVRLS PGKETRCSPP SFTYKYTPEE
     EQELEKQVTE HDGQSLVKST IFIPPSSVKK EEAPQSEGTR LEECHHGRLA PCPQFAPISQ
     STCSLHSVHS EWQDRPLCEH MRTLSAHSVP NISGAACSAF SSPFGCPYSH RHAAHPCRPC
     PVNPPSAIEM QLRRVLHDIR NSLQNLSQYP MTRGPDLAAA PYSTQKSSVL PLYENTFQEL
     QVVRRSLNLF RTQMMDLELA MLRQQTVVYP HMTEEDRYEV DQLQGLRNSV RMELQDLELQ
     LEERLLGLDE QLRAVRVPSP FRSSALPGMC GSRSADNLSC PSPLNVMEPV TELMREQSYL
     KSELGLSLGD MGYEIPPGES SESVFSQATS ESSSVCSSPS HTNRRSRGPS GSKPRARLVA
     RKKIFRASVA LTPTAPSRTG SVQTPPDLES SEEAGAAEEA SQVVGLTSHV EEEPEDLSLM
     PTAEEMHRNV EQDELQQVIR EIKESIVGEI RREIVSGLLA AVSSSKASAS KQDSH
//