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Protein

Sesquipedalian-1

Gene

Fam109a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sesquipedalian-1
Short name:
Ses1
Alternative name(s):
27 kDa inositol polyphosphate phosphatase interacting protein A
Short name:
IPIP27A
Gene namesi
Name:Fam109a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1310656. Fam109a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Sesquipedalian-1PRO_0000406047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZL52.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028206.
GenevisibleiD3ZL52. RN.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FAM109B (By similarity). Interacts with INPP5B (By similarity). Interacts with OCRL. Interaction with OCRL may be important for endosomal morphology and function (By similarity).By similarity

Protein-protein interaction databases

BioGridi252645. 1 interaction.
STRINGi10116.ENSRNOP00000034778.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 11397PHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi191 – 20313F&HAdd
BLAST

Domaini

The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.By similarity

Sequence similaritiesi

Belongs to the sesquipedalian family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH44. Eukaryota.
ENOG4111J7G. LUCA.
GeneTreeiENSGT00440000034671.
InParanoidiD3ZL52.
OMAiTRARTYV.
OrthoDBiEOG091G0IU5.
PhylomeDBiD3ZL52.
TreeFamiTF326731.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZL52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNERSLAF YATCDAPVDN AGFLYKRGGR GAGSHRRWFV LRGNILFYFE
60 70 80 90 100
SESSREPLGV ILLEGCTVEL VDAREEFAFA VRFAGGRSRP YVLAADSQAA
110 120 130 140 150
LEGWVKALSR ASFHYLRLVV RELEQQLAAM REGSPANALP DANPSTVLNP
160 170 180 190 200
KPKENGRAVW SALPEQPAVA PRRPPLPPRR RASAANGPSV SFAQLHERYG
210 220 230
LEVRALRNQW RGGLTSLEVP CHPGSGETQT QDQP
Length:234
Mass (Da):25,793
Last modified:April 20, 2010 - v1
Checksum:i686F1B4DDEA6D29A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473973 Genomic DNA. Translation: EDM13713.1.
RefSeqiXP_002724867.1. XM_002724821.3.
XP_002728013.1. XM_002727967.3.
XP_006221417.1. XM_006221355.2.
XP_006249472.1. XM_006249410.2.

Genome annotation databases

EnsembliENSRNOT00000030600; ENSRNOP00000034778; ENSRNOG00000028206.
GeneIDi288664.
KEGGirno:288664.
UCSCiRGD:1310656. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473973 Genomic DNA. Translation: EDM13713.1.
RefSeqiXP_002724867.1. XM_002724821.3.
XP_002728013.1. XM_002727967.3.
XP_006221417.1. XM_006221355.2.
XP_006249472.1. XM_006249410.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252645. 1 interaction.
STRINGi10116.ENSRNOP00000034778.

Proteomic databases

PaxDbiD3ZL52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030600; ENSRNOP00000034778; ENSRNOG00000028206.
GeneIDi288664.
KEGGirno:288664.
UCSCiRGD:1310656. rat.

Organism-specific databases

CTDi144717.
RGDi1310656. Fam109a.

Phylogenomic databases

eggNOGiENOG410IH44. Eukaryota.
ENOG4111J7G. LUCA.
GeneTreeiENSGT00440000034671.
InParanoidiD3ZL52.
OMAiTRARTYV.
OrthoDBiEOG091G0IU5.
PhylomeDBiD3ZL52.
TreeFamiTF326731.

Miscellaneous databases

PROiD3ZL52.

Gene expression databases

BgeeiENSRNOG00000028206.
GenevisibleiD3ZL52. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSESQ1_RAT
AccessioniPrimary (citable) accession number: D3ZL52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.