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Protein

Sesquipedalian-1

Gene

Fam109a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sesquipedalian-1
Short name:
Ses1
Alternative name(s):
27 kDa inositol polyphosphate phosphatase interacting protein A
Short name:
IPIP27A
Gene namesi
Name:Fam109a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1310656 Fam109a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004060471 – 234Sesquipedalian-1Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZL52
PRIDEiD3ZL52

Expressioni

Gene expression databases

BgeeiENSRNOG00000028206
GenevisibleiD3ZL52 RN

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FAM109B (By similarity). Interacts with INPP5B (By similarity). Interacts with OCRL. Interaction with OCRL may be important for endosomal morphology and function (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi252645, 1 interactor
STRINGi10116.ENSRNOP00000034778

Structurei

3D structure databases

SMRiD3ZL52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 113PHPROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi191 – 203F&HAdd BLAST13

Domaini

The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.By similarity

Sequence similaritiesi

Belongs to the sesquipedalian family.Curated

Phylogenomic databases

eggNOGiENOG410IH44 Eukaryota
ENOG4111J7G LUCA
GeneTreeiENSGT00440000034671
InParanoidiD3ZL52
OMAiTRARTYV
OrthoDBiEOG091G0IU5
PhylomeDBiD3ZL52
TreeFamiTF326731

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZL52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNERSLAF YATCDAPVDN AGFLYKRGGR GAGSHRRWFV LRGNILFYFE
60 70 80 90 100
SESSREPLGV ILLEGCTVEL VDAREEFAFA VRFAGGRSRP YVLAADSQAA
110 120 130 140 150
LEGWVKALSR ASFHYLRLVV RELEQQLAAM REGSPANALP DANPSTVLNP
160 170 180 190 200
KPKENGRAVW SALPEQPAVA PRRPPLPPRR RASAANGPSV SFAQLHERYG
210 220 230
LEVRALRNQW RGGLTSLEVP CHPGSGETQT QDQP
Length:234
Mass (Da):25,793
Last modified:April 20, 2010 - v1
Checksum:i686F1B4DDEA6D29A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473973 Genomic DNA Translation: EDM13713.1
RefSeqiXP_002724867.1, XM_002724821.4
XP_002728013.1, XM_002727967.4
XP_006221417.1, XM_006221355.3
XP_006249472.1, XM_006249410.3
XP_017454009.1, XM_017598520.1
XP_017459974.1, XM_017604485.1

Genome annotation databases

EnsembliENSRNOT00000030600; ENSRNOP00000034778; ENSRNOG00000028206
GeneIDi288664
KEGGirno:288664
UCSCiRGD:1310656 rat

Similar proteinsi

Entry informationi

Entry nameiSESQ1_RAT
AccessioniPrimary (citable) accession number: D3ZL52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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