Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D3ZKB9

- TSH3_RAT

UniProt

D3ZKB9 - TSH3_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Teashirt homolog 3

Gene

Tshz3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 40025C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
DNA bindingi882 – 95271Homeobox; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri967 – 98923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1032 – 105524C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. DNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. in utero embryonic development Source: Ensembl
  2. kidney morphogenesis Source: Ensembl
  3. kidney smooth muscle cell differentiation Source: Ensembl
  4. lung development Source: Ensembl
  5. metanephros development Source: Ensembl
  6. musculoskeletal movement Source: Ensembl
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. positive regulation of smooth muscle cell differentiation Source: Ensembl
  9. regulation of respiratory gaseous exchange by neurological system process Source: UniProtKB
  10. sensory perception of touch Source: Ensembl
  11. transcription, DNA-templated Source: UniProtKB-KW
  12. ureteric bud development Source: Ensembl
  13. ureteric peristalsis Source: Ensembl
  14. ureter smooth muscle cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 3
Alternative name(s):
Zinc finger protein 537
Gene namesi
Name:Tshz3
Synonyms:Zfp537
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1306322. Tshz3.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation. Cell projectiongrowth cone 1 Publication
Note: Colocalizes with APBB1 in the nucleus (By similarity). Colocalizes with APBB1 in axonal growth cone.By similarity

GO - Cellular componenti

  1. growth cone Source: UniProtKB
  2. mitochondrion Source: Ensembl
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10721072Teashirt homolog 3PRO_0000399476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei672 – 6721PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Expressed in cortical neurons.1 Publication

Interactioni

Subunit structurei

Interacts (via N-terminus) with HDAC1 and HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3 (By similarity). Interacts (via homeobox domain) with APBB1 (via PID domain 1).By similarity1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi131 – 15424Ser-richAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 40025C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri967 – 98923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1032 – 105524C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

InParanoidiD3ZKB9.
KOiK09236.
OrthoDBiEOG7NPFSF.
PhylomeDBiD3ZKB9.
TreeFamiTF328447.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR026810. Tshz3.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF5. PTHR12487:SF5. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZKB9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAYVSDELK AAALVEDDIE PEEQVADGEP SAKYMCPEKE LSKACPSYQN
60 70 80 90 100
SPAAEFSSHE MDSESHISET SDRMADFESS SIKNEEETKE VQVPLEDTTV
110 120 130 140 150
SDSLEQMKAV YNNFLSNSYW SNLNLNLHQP SSENNGGGSS SSSSSSSSSC
160 170 180 190 200
GSGSFDWHQS AMAKTLQQVS QNRMLPEPSL FSTVQLYRQS SKLYGSIFTG
210 220 230 240 250
ASKFRCKDCS AAYDTLVELT VHMNETGHYR DDNHETDNNN PKRWSKPRKR
260 270 280 290 300
SLLEMEGKED AQKVLKCMYC GHSFESLQDL SVHMIKTKHY QKVPLKEPVT
310 320 330 340 350
PVAAKIIPAA RKKPSLELEL PSSPDSTGGT PKATLSDASD ALQKNSNPYI
360 370 380 390 400
TPNNRYGHQN GASYAWHFEA RKSQILKCME CGSSHDTLQE LTAHMMVTGH
410 420 430 440 450
FIKVTNSAMK KGKPIMETPV TPTITTLLDE KVQSVPLAAT TFTSPSNTPA
460 470 480 490 500
SVSPKLTVEI KKEVDKEKAV LDEKPKEKEK ASEEEEKYDI SSKYHYLTEN
510 520 530 540 550
DLEESPKGGL DILKSLENTV TSAINKAQNG TPSWGGYPSI HAAYQLPNMM
560 570 580 590 600
KLSLGSSGKS TPLKPMFGNS EIVSPTKTQT LVSPPSSQTS PMPKTNFHAM
610 620 630 640 650
EELVKKVTEK VAKVEEKMKE PDSKLSPPKR ATPSPCSSEQ SEPIKMEASS
660 670 680 690 700
GSGFKSQENS PSPPRDVCKE ASPSAEPVEN GKELVKPLSG GSLSGSTAII
710 720 730 740 750
TDHPPEQPFV NPLSALQSVM NIHLGKAAKP SLPALDPMSM LFKMSNSLAE
760 770 780 790 800
KAAVATPPPL QAKKAEHLDR YFYHVNNDQP IDLTKGKSDK GCSLGSGLLS
810 820 830 840 850
PTSTSPATSS STVTTAKTSA VVSFMSNSPL RENALSDISD MLKNLTESHT
860 870 880 890 900
SKSSTPSSIS EKSDIDGATL EEAEESTPAQ KRKGRQSNWN PQHLLILQAQ
910 920 930 940 950
FAASLRQTSE GKYIMSDLSP QERMHISRFT GLSMTTISHW LANVKYQLRR
960 970 980 990 1000
TGGTKFLKNL DTGHPVFFCN DCASQIRTPS TYISHLESHL GFRLRDLSKL
1010 1020 1030 1040 1050
STEQINNQIA QTKSPSEKMV TSSPEEDLGT TYQCKLCNRT FASKHAVKLH
1060 1070
LSKTHGKSPE DHLLFVSELE KQ
Length:1,072
Mass (Da):117,463
Last modified:October 5, 2010 - v2
Checksum:i9CB7824517771F35
GO

Sequence cautioni

The sequence EDM07600.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473979 Genomic DNA. Translation: EDM07600.1. Different initiation.
RefSeqiNP_001100976.1. NM_001107506.1.
UniGeneiRn.9411.

Genome annotation databases

GeneIDi308523.
KEGGirno:308523.
UCSCiRGD:1306322. rat.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life's first breath - Issue 122 of October 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473979 Genomic DNA. Translation: EDM07600.1 . Different initiation.
RefSeqi NP_001100976.1. NM_001107506.1.
UniGenei Rn.9411.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 308523.
KEGGi rno:308523.
UCSCi RGD:1306322. rat.

Organism-specific databases

CTDi 57616.
RGDi 1306322. Tshz3.

Phylogenomic databases

InParanoidi D3ZKB9.
KOi K09236.
OrthoDBi EOG7NPFSF.
PhylomeDBi D3ZKB9.
TreeFami TF328447.

Miscellaneous databases

NextBioi 659069.
PROi D3ZKB9.

Family and domain databases

InterProi IPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR026810. Tshz3.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
PANTHERi PTHR12487. PTHR12487. 1 hit.
PTHR12487:SF5. PTHR12487:SF5. 1 hit.
SMARTi SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Cited for: INTERACTION WITH APBB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTSH3_RAT
AccessioniPrimary (citable) accession number: D3ZKB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3