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D3ZKB9

- TSH3_RAT

UniProt

D3ZKB9 - TSH3_RAT

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Protein

Teashirt homolog 3

Gene
Tshz3, Zfp537
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22825C2H2-type 1Add
BLAST
Zinc fingeri265 – 28925C2H2-type 2Add
BLAST
Zinc fingeri376 – 40025C2H2-type 3; atypicalAdd
BLAST
DNA bindingi882 – 95271Homeobox; atypicalAdd
BLAST
Zinc fingeri967 – 98923C2H2-type 4Add
BLAST
Zinc fingeri1032 – 105524C2H2-type 5Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: UniProtKB
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. in utero embryonic development Source: Ensembl
  2. kidney morphogenesis Source: Ensembl
  3. kidney smooth muscle cell differentiation Source: Ensembl
  4. lung development Source: Ensembl
  5. metanephros development Source: Ensembl
  6. musculoskeletal movement Source: Ensembl
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. positive regulation of smooth muscle cell differentiation Source: Ensembl
  9. regulation of respiratory gaseous exchange by neurological system process Source: UniProtKB
  10. sensory perception of touch Source: Ensembl
  11. transcription, DNA-templated Source: UniProtKB-KW
  12. ureteric bud development Source: Ensembl
  13. ureteric peristalsis Source: Ensembl
  14. ureter smooth muscle cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 3
Alternative name(s):
Zinc finger protein 537
Gene namesi
Name:Tshz3
Synonyms:Zfp537
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1306322. Tshz3.

Subcellular locationi

Nucleus. Cell projectiongrowth cone
Note: Colocalizes with APBB1 in the nucleus By similarity. Colocalizes with APBB1 in axonal growth cone.1 Publication

GO - Cellular componenti

  1. growth cone Source: UniProtKB
  2. mitochondrion Source: Ensembl
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10721072Teashirt homolog 3PRO_0000399476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei672 – 6721Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Expressed in cortical neurons.1 Publication

Interactioni

Subunit structurei

Interacts (via N-terminus) with HDAC1 and HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3 By similarity. Interacts (via homeobox domain) with APBB1 (via PID domain 1).1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi131 – 15424Ser-richAdd
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22825C2H2-type 1Add
BLAST
Zinc fingeri265 – 28925C2H2-type 2Add
BLAST
Zinc fingeri376 – 40025C2H2-type 3; atypicalAdd
BLAST
Zinc fingeri967 – 98923C2H2-type 4Add
BLAST
Zinc fingeri1032 – 105524C2H2-type 5Add
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

KOiK09236.
OrthoDBiEOG7NPFSF.
PhylomeDBiD3ZKB9.
TreeFamiTF328447.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR026810. Tshz3.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF5. PTHR12487:SF5. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZKB9-1 [UniParc]FASTAAdd to Basket

« Hide

MAAYVSDELK AAALVEDDIE PEEQVADGEP SAKYMCPEKE LSKACPSYQN     50
SPAAEFSSHE MDSESHISET SDRMADFESS SIKNEEETKE VQVPLEDTTV 100
SDSLEQMKAV YNNFLSNSYW SNLNLNLHQP SSENNGGGSS SSSSSSSSSC 150
GSGSFDWHQS AMAKTLQQVS QNRMLPEPSL FSTVQLYRQS SKLYGSIFTG 200
ASKFRCKDCS AAYDTLVELT VHMNETGHYR DDNHETDNNN PKRWSKPRKR 250
SLLEMEGKED AQKVLKCMYC GHSFESLQDL SVHMIKTKHY QKVPLKEPVT 300
PVAAKIIPAA RKKPSLELEL PSSPDSTGGT PKATLSDASD ALQKNSNPYI 350
TPNNRYGHQN GASYAWHFEA RKSQILKCME CGSSHDTLQE LTAHMMVTGH 400
FIKVTNSAMK KGKPIMETPV TPTITTLLDE KVQSVPLAAT TFTSPSNTPA 450
SVSPKLTVEI KKEVDKEKAV LDEKPKEKEK ASEEEEKYDI SSKYHYLTEN 500
DLEESPKGGL DILKSLENTV TSAINKAQNG TPSWGGYPSI HAAYQLPNMM 550
KLSLGSSGKS TPLKPMFGNS EIVSPTKTQT LVSPPSSQTS PMPKTNFHAM 600
EELVKKVTEK VAKVEEKMKE PDSKLSPPKR ATPSPCSSEQ SEPIKMEASS 650
GSGFKSQENS PSPPRDVCKE ASPSAEPVEN GKELVKPLSG GSLSGSTAII 700
TDHPPEQPFV NPLSALQSVM NIHLGKAAKP SLPALDPMSM LFKMSNSLAE 750
KAAVATPPPL QAKKAEHLDR YFYHVNNDQP IDLTKGKSDK GCSLGSGLLS 800
PTSTSPATSS STVTTAKTSA VVSFMSNSPL RENALSDISD MLKNLTESHT 850
SKSSTPSSIS EKSDIDGATL EEAEESTPAQ KRKGRQSNWN PQHLLILQAQ 900
FAASLRQTSE GKYIMSDLSP QERMHISRFT GLSMTTISHW LANVKYQLRR 950
TGGTKFLKNL DTGHPVFFCN DCASQIRTPS TYISHLESHL GFRLRDLSKL 1000
STEQINNQIA QTKSPSEKMV TSSPEEDLGT TYQCKLCNRT FASKHAVKLH 1050
LSKTHGKSPE DHLLFVSELE KQ 1072
Length:1,072
Mass (Da):117,463
Last modified:October 5, 2010 - v2
Checksum:i9CB7824517771F35
GO

Sequence cautioni

The sequence EDM07600.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH473979 Genomic DNA. Translation: EDM07600.1. Different initiation.
RefSeqiNP_001100976.1. NM_001107506.1.
XP_006228956.1. XM_006228894.1.
XP_006228957.1. XM_006228895.1.
UniGeneiRn.9411.

Genome annotation databases

GeneIDi308523.
KEGGirno:308523.
UCSCiRGD:1306322. rat.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life's first breath - Issue 122 of October 2010

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH473979 Genomic DNA. Translation: EDM07600.1 . Different initiation.
RefSeqi NP_001100976.1. NM_001107506.1.
XP_006228956.1. XM_006228894.1.
XP_006228957.1. XM_006228895.1.
UniGenei Rn.9411.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 308523.
KEGGi rno:308523.
UCSCi RGD:1306322. rat.

Organism-specific databases

CTDi 57616.
RGDi 1306322. Tshz3.

Phylogenomic databases

KOi K09236.
OrthoDBi EOG7NPFSF.
PhylomeDBi D3ZKB9.
TreeFami TF328447.

Miscellaneous databases

NextBioi 659069.
PROi D3ZKB9.

Family and domain databases

InterProi IPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR026810. Tshz3.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
PANTHERi PTHR12487. PTHR12487. 1 hit.
PTHR12487:SF5. PTHR12487:SF5. 1 hit.
SMARTi SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Cited for: INTERACTION WITH APBB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTSH3_RAT
AccessioniPrimary (citable) accession number: D3ZKB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 11, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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