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D3ZKB9

- TSH3_RAT

UniProt

D3ZKB9 - TSH3_RAT

Protein

Teashirt homolog 3

Gene

Tshz3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri204 – 22825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri265 – 28925C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri376 – 40025C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi882 – 95271Homeobox; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri967 – 98923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1032 – 105524C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: InterPro
    5. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. in utero embryonic development Source: Ensembl
    2. kidney morphogenesis Source: Ensembl
    3. kidney smooth muscle cell differentiation Source: Ensembl
    4. lung development Source: Ensembl
    5. metanephros development Source: Ensembl
    6. musculoskeletal movement Source: Ensembl
    7. negative regulation of transcription, DNA-templated Source: UniProtKB
    8. positive regulation of smooth muscle cell differentiation Source: Ensembl
    9. regulation of respiratory gaseous exchange by neurological system process Source: UniProtKB
    10. sensory perception of touch Source: Ensembl
    11. transcription, DNA-templated Source: UniProtKB-KW
    12. ureteric bud development Source: Ensembl
    13. ureteric peristalsis Source: Ensembl
    14. ureter smooth muscle cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Teashirt homolog 3
    Alternative name(s):
    Zinc finger protein 537
    Gene namesi
    Name:Tshz3
    Synonyms:Zfp537
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1306322. Tshz3.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation. Cell projectiongrowth cone 1 Publication
    Note: Colocalizes with APBB1 in the nucleus By similarity. Colocalizes with APBB1 in axonal growth cone.By similarity

    GO - Cellular componenti

    1. growth cone Source: UniProtKB
    2. mitochondrion Source: Ensembl
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10721072Teashirt homolog 3PRO_0000399476Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei672 – 6721PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Tissue specificityi

    Expressed in cortical neurons.1 Publication

    Interactioni

    Subunit structurei

    Interacts (via N-terminus) with HDAC1 and HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3 By similarity. Interacts (via homeobox domain) with APBB1 (via PID domain 1).By similarity1 Publication

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi131 – 15424Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri204 – 22825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri265 – 28925C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri376 – 40025C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri967 – 98923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1032 – 105524C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Homeobox, Repeat, Zinc-finger

    Phylogenomic databases

    KOiK09236.
    OrthoDBiEOG7NPFSF.
    PhylomeDBiD3ZKB9.
    TreeFamiTF328447.

    Family and domain databases

    InterProiIPR001356. Homeobox_dom.
    IPR027008. Teashirt_fam.
    IPR026810. Tshz3.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PANTHERiPTHR12487. PTHR12487. 1 hit.
    PTHR12487:SF5. PTHR12487:SF5. 1 hit.
    SMARTiSM00389. HOX. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3ZKB9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAYVSDELK AAALVEDDIE PEEQVADGEP SAKYMCPEKE LSKACPSYQN     50
    SPAAEFSSHE MDSESHISET SDRMADFESS SIKNEEETKE VQVPLEDTTV 100
    SDSLEQMKAV YNNFLSNSYW SNLNLNLHQP SSENNGGGSS SSSSSSSSSC 150
    GSGSFDWHQS AMAKTLQQVS QNRMLPEPSL FSTVQLYRQS SKLYGSIFTG 200
    ASKFRCKDCS AAYDTLVELT VHMNETGHYR DDNHETDNNN PKRWSKPRKR 250
    SLLEMEGKED AQKVLKCMYC GHSFESLQDL SVHMIKTKHY QKVPLKEPVT 300
    PVAAKIIPAA RKKPSLELEL PSSPDSTGGT PKATLSDASD ALQKNSNPYI 350
    TPNNRYGHQN GASYAWHFEA RKSQILKCME CGSSHDTLQE LTAHMMVTGH 400
    FIKVTNSAMK KGKPIMETPV TPTITTLLDE KVQSVPLAAT TFTSPSNTPA 450
    SVSPKLTVEI KKEVDKEKAV LDEKPKEKEK ASEEEEKYDI SSKYHYLTEN 500
    DLEESPKGGL DILKSLENTV TSAINKAQNG TPSWGGYPSI HAAYQLPNMM 550
    KLSLGSSGKS TPLKPMFGNS EIVSPTKTQT LVSPPSSQTS PMPKTNFHAM 600
    EELVKKVTEK VAKVEEKMKE PDSKLSPPKR ATPSPCSSEQ SEPIKMEASS 650
    GSGFKSQENS PSPPRDVCKE ASPSAEPVEN GKELVKPLSG GSLSGSTAII 700
    TDHPPEQPFV NPLSALQSVM NIHLGKAAKP SLPALDPMSM LFKMSNSLAE 750
    KAAVATPPPL QAKKAEHLDR YFYHVNNDQP IDLTKGKSDK GCSLGSGLLS 800
    PTSTSPATSS STVTTAKTSA VVSFMSNSPL RENALSDISD MLKNLTESHT 850
    SKSSTPSSIS EKSDIDGATL EEAEESTPAQ KRKGRQSNWN PQHLLILQAQ 900
    FAASLRQTSE GKYIMSDLSP QERMHISRFT GLSMTTISHW LANVKYQLRR 950
    TGGTKFLKNL DTGHPVFFCN DCASQIRTPS TYISHLESHL GFRLRDLSKL 1000
    STEQINNQIA QTKSPSEKMV TSSPEEDLGT TYQCKLCNRT FASKHAVKLH 1050
    LSKTHGKSPE DHLLFVSELE KQ 1072
    Length:1,072
    Mass (Da):117,463
    Last modified:October 5, 2010 - v2
    Checksum:i9CB7824517771F35
    GO

    Sequence cautioni

    The sequence EDM07600.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473979 Genomic DNA. Translation: EDM07600.1. Different initiation.
    RefSeqiNP_001100976.1. NM_001107506.1.
    XP_006228956.1. XM_006228894.1.
    XP_006228957.1. XM_006228895.1.
    UniGeneiRn.9411.

    Genome annotation databases

    GeneIDi308523.
    KEGGirno:308523.
    UCSCiRGD:1306322. rat.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life's first breath - Issue 122 of October 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473979 Genomic DNA. Translation: EDM07600.1 . Different initiation.
    RefSeqi NP_001100976.1. NM_001107506.1.
    XP_006228956.1. XM_006228894.1.
    XP_006228957.1. XM_006228895.1.
    UniGenei Rn.9411.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 308523.
    KEGGi rno:308523.
    UCSCi RGD:1306322. rat.

    Organism-specific databases

    CTDi 57616.
    RGDi 1306322. Tshz3.

    Phylogenomic databases

    KOi K09236.
    OrthoDBi EOG7NPFSF.
    PhylomeDBi D3ZKB9.
    TreeFami TF328447.

    Miscellaneous databases

    NextBioi 659069.
    PROi D3ZKB9.

    Family and domain databases

    InterProi IPR001356. Homeobox_dom.
    IPR027008. Teashirt_fam.
    IPR026810. Tshz3.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    PANTHERi PTHR12487. PTHR12487. 1 hit.
    PTHR12487:SF5. PTHR12487:SF5. 1 hit.
    SMARTi SM00389. HOX. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. Cited for: INTERACTION WITH APBB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTSH3_RAT
    AccessioniPrimary (citable) accession number: D3ZKB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3