Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Germ cell-specific gene 1-like protein

Gene

Gsg1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a component of the inner core of AMPAR complexes, modifies AMPA receptor (AMPAR) gating.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Germ cell-specific gene 1-like protein
Short name:
GSG1-like protein
Gene namesi
Name:Gsg1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1562278 Gsg1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 122ExtracellularSequence analysisAdd BLAST93
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 163CytoplasmicSequence analysisAdd BLAST20
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 207ExtracellularSequence analysisAdd BLAST23
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 322CytoplasmicSequence analysisAdd BLAST94

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004206851 – 322Germ cell-specific gene 1-like proteinAdd BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZK93
PRIDEiD3ZK93

PTM databases

iPTMnetiD3ZK93
PhosphoSitePlusiD3ZK93

Expressioni

Tissue specificityi

Expressed in the brain (at protein level).1 Publication

Interactioni

Subunit structurei

Component of the inner core of AMPAR complexes. AMPAR complexes consist of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complexes is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complexes and profoundly impact their biogenesis and protein processing.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022392

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VHWelectron microscopy7.80A/B/C/D2-238[»]
5VHXelectron microscopy8.30A/B/C/D/E2-238[»]
5VHYelectron microscopy4.60A/B/C/D/E/F2-238[»]
5VHZelectron microscopy8.40A/B/C/D/E/F2-238[»]
SMRiD3ZK93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAK Eukaryota
ENOG410ZXFF LUCA
InParanoidiD3ZK93
PhylomeDBiD3ZK93
TreeFamiTF331388

Family and domain databases

InterProiView protein in InterPro
IPR012478 GSG-1
PfamiView protein in Pfam
PF07803 GSG-1, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZK93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSRRGRAL LAVALNLLAL LFATTAFLTT YWCQGTQRVP KPGCGQGGGA
60 70 80 90 100
NCPNSGANAT ANSTAAPVAA SPAGAPYSWE AGDERFQLRR FHTGIWYSCE
110 120 130 140 150
EELGGPGEKC RSFIDLAPAS EKGVLWLSVV SEVLYILLLV VGFSLMCLEL
160 170 180 190 200
LHSSSVIDGL KLNAFAAVFT VLSGLLGMVA HMMYTQVFQV TVSLGPEDWR
210 220 230 240 250
PHSWDYGWSF CLAWGSFTCC MAASVTTLNS YTKTVIEFRH KRKVFEQGYR
260 270 280 290 300
EEPTFIDPEA IKYFRERIEK GDVSEEEDFR LACRHERYPT RHQPHMGDSW
310 320
PRSSAHEAAE LNRQCWVLGH WV
Length:322
Mass (Da):35,903
Last modified:April 20, 2010 - v1
Checksum:i30388DA6545A5EA1
GO

Genome annotation databases

UCSCiRGD:1562278 rat

Similar proteinsi

Entry informationi

Entry nameiGSG1L_RAT
AccessioniPrimary (citable) accession number: D3ZK93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health