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Protein

T-box transcription factor TBX6

Gene

Tbx6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to also play an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi100 – 273T-boxPROSITE-ProRule annotationAdd BLAST174

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX6
Short name:
T-box protein 6
Gene namesi
Name:Tbx6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307716 Tbx6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004170431 – 436T-box transcription factor TBX6Add BLAST436

Proteomic databases

PaxDbiD3ZJK7

Expressioni

Gene expression databases

BgeeiENSRNOG00000019771

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060687

Structurei

3D structure databases

SMRiD3ZJK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00760000118897
InParanoidiD3ZJK7
KOiK10180
OMAiLHPAAFH
OrthoDBiEOG091G0I8R

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR002070 TF_Brachyury
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00938 BRACHYURY
PR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZJK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHPRELYPS LGTGYRLGHP QPGADSTFPP ALTEGYRYPD LDTSKLDCFL
60 70 80 90 100
SGIEAAPHTL AAPPPLPLLP SALGPETAPP PPEALHSLPG VSLSLENQEL
110 120 130 140 150
WKEFSAVGTE MIITKAGRRM FPACRVSVTG LDPEARYLFL LDVVPVDGAR
160 170 180 190 200
YRWQGQHWEP SGKAEPRLPD RVYIHPDSPA TGAHWMRQPV SFHRVKLTNS
210 220 230 240 250
TLDPHGHLIL HSMHKYQPRI HLVRATQLCS QHWGGVASFR FPETTFISVT
260 270 280 290 300
AYQNPRITQL KIAANPFAKG FRENGRNCKR ERDARVKRKL RGPEPVATEA
310 320 330 340 350
CGSGDTPGGP CDSTLGGDIR DSDPEPAPTP QEAASASAPP CGGPSAEAYL
360 370 380 390 400
LHPAAFHGAP SHLPARTPSF PEAPDPGRPA PYSAAFLELQ PGPGSSAYQT
410 420 430
TPSVTPFAPH FIQGAPFPLP YPGPGGYLDM GSKQMY
Length:436
Mass (Da):47,216
Last modified:April 20, 2010 - v1
Checksum:i707BF9BF5C26BA73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03000696 Genomic DNA No translation available.
CH473956 Genomic DNA Translation: EDM17394.1
RefSeqiNP_001102390.1, NM_001108920.1
UniGeneiRn.99342

Genome annotation databases

EnsembliENSRNOT00000068543; ENSRNOP00000060687; ENSRNOG00000019771
GeneIDi365371
KEGGirno:365371

Similar proteinsi

Entry informationi

Entry nameiTBX6_RAT
AccessioniPrimary (citable) accession number: D3ZJK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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