ID D3ZHJ4_RAT Unreviewed; 412 AA. AC D3ZHJ4; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 27-MAR-2024, entry version 85. DE SubName: Full=Docking protein 2 {ECO:0000313|Ensembl:ENSRNOP00000018725.5}; GN Name=Dok2 {ECO:0000313|Ensembl:ENSRNOP00000018725.5, GN ECO:0000313|RGD:1310966}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000018725.5, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000018725.5, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000018725.5, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000018725.5} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000018725.5}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the DOK family. Type A subfamily. CC {ECO:0000256|ARBA:ARBA00010955}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006252326.1; XM_006252264.3. DR AlphaFoldDB; D3ZHJ4; -. DR SMR; D3ZHJ4; -. DR STRING; 10116.ENSRNOP00000018725; -. DR PaxDb; 10116-ENSRNOP00000018725; -. DR Ensembl; ENSRNOT00000018725.7; ENSRNOP00000018725.5; ENSRNOG00000013922.7. DR UCSC; RGD:1310966; rat. DR AGR; RGD:1310966; -. DR CTD; 9046; -. DR RGD; 1310966; Dok2. DR eggNOG; KOG4047; Eukaryota. DR GeneTree; ENSGT00940000159868; -. DR HOGENOM; CLU_030101_2_0_1; -. DR InParanoid; D3ZHJ4; -. DR OrthoDB; 2996885at2759; -. DR PhylomeDB; D3ZHJ4; -. DR TreeFam; TF324994; -. DR Reactome; R-RNO-210993; Tie2 Signaling. DR Reactome; R-RNO-8853659; RET signaling. DR Proteomes; UP000002494; Chromosome 15. DR Bgee; ENSRNOG00000013922; Expressed in thymus and 19 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; ISO:RGD. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central. DR GO; GO:0007265; P:Ras protein signal transduction; ISO:RGD. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISO:RGD. DR CDD; cd01203; PTB_DOK1_DOK2_DOK3; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2. DR InterPro; IPR037751; Dok1/2/3_PTB. DR InterPro; IPR002404; IRS_PTB. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR001849; PH_domain. DR PANTHER; PTHR21258:SF14; DOCKING PROTEIN 2; 1. DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1. DR Pfam; PF02174; IRS; 1. DR Pfam; PF00169; PH; 1. DR SMART; SM01244; IRS; 1. DR SMART; SM00233; PH; 1. DR SMART; SM00310; PTBI; 1. DR SUPFAM; SSF50729; PH domain-like; 2. DR PROSITE; PS51064; IRS_PTB; 1. DR PROSITE; PS50003; PH_DOMAIN; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 7..117 FT /note="PH" FT /evidence="ECO:0000259|PROSITE:PS50003" FT DOMAIN 149..254 FT /note="IRS-type PTB" FT /evidence="ECO:0000259|PROSITE:PS51064" FT REGION 248..301 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 366..395 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 277..291 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 412 AA; 45332 MW; A03971D515C2DD95 CRC64; MVRMGEMAVK QGLLHLQQQQ TFGKKWRRFT AVLYGESGCA LARLELQDGP EKTRRGEATR KVVRLSDCLR VAEVGSEASS PRDTSAFILE TKERLYLLAA PSTERSDWIQ AICLLAFPGQ RKESPGLEEK NGSPCMEENE LYSSSTTGVC KEYAVTIRPT EASERCRLRG SYTLRTGVSA LELWGGPEPG TQLYDWPYRF LRRFGRDKVT FSFEAGRRCV SGEGSFEFET RQGNEIFQAL EKAIAAQKNA TPSGPPTLPA TGSMMPTALP RPESPYSRPH DSLPSPSPGT PVPGIRSGGS EGEYAVPFDT VVHSLKKSFR GILTGPPPLL PDPLYDSIQE DPVVPLPDHI YDEPEGVAAL SLYERSQKPS GETWREQATA DGGTNSLQQD SSVSGWPQVT EYDNVILKKG PK //