ID D3ZHH8_RAT Unreviewed; 504 AA. AC D3ZHH8; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 2. DT 27-MAR-2024, entry version 108. DE SubName: Full=Serum response factor {ECO:0000313|Ensembl:ENSRNOP00000058149.3}; GN Name=Srf {ECO:0000313|Ensembl:ENSRNOP00000058149.3, GN ECO:0000313|RGD:1559787}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000058149.3, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000058149.3, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058149.3, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0007829|PubMed:22673903} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22673903; RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., RA Olsen J.V.; RT "Quantitative maps of protein phosphorylation sites across 14 different rat RT organs and tissues."; RL Nat. Commun. 3:876-876(2012). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000058149.3} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058149.3}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001102772.1; NM_001109302.1. DR RefSeq; XP_006244619.1; XM_006244557.3. DR AlphaFoldDB; D3ZHH8; -. DR SMR; D3ZHH8; -. DR STRING; 10116.ENSRNOP00000058149; -. DR PhosphoSitePlus; D3ZHH8; -. DR PaxDb; 10116-ENSRNOP00000058149; -. DR Ensembl; ENSRNOT00000061430.4; ENSRNOP00000058149.3; ENSRNOG00000018232.7. DR GeneID; 501099; -. DR KEGG; rno:501099; -. DR UCSC; RGD:1559787; rat. DR AGR; RGD:1559787; -. DR CTD; 6722; -. DR RGD; 1559787; Srf. DR eggNOG; KOG0015; Eukaryota. DR GeneTree; ENSGT00400000022158; -. DR HOGENOM; CLU_042048_1_0_1; -. DR OMA; GCLKREA; -. DR OrthoDB; 832279at2759; -. DR TreeFam; TF318482; -. DR Reactome; R-RNO-5663220; RHO GTPases Activate Formins. DR Reactome; R-RNO-9031628; NGF-stimulated transcription. DR Proteomes; UP000002494; Chromosome 9. DR Bgee; ENSRNOG00000018232; Expressed in skeletal muscle tissue and 19 other cell types or tissues. DR GO; GO:0000785; C:chromatin; ISO:RGD. DR GO; GO:0005737; C:cytoplasm; ISO:RGD. DR GO; GO:0005634; C:nucleus; ISO:RGD. DR GO; GO:0003682; F:chromatin binding; ISO:RGD. DR GO; GO:0031490; F:chromatin DNA binding; ISO:RGD. DR GO; GO:0003677; F:DNA binding; ISO:RGD. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD. DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:RGD. DR GO; GO:0140297; F:DNA-binding transcription factor binding; ISO:RGD. DR GO; GO:0042826; F:histone deacetylase binding; IPI:RGD. DR GO; GO:0070878; F:primary miRNA binding; ISO:RGD. DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD. DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:RGD. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD. DR GO; GO:0010736; F:serum response element binding; ISO:RGD. DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:RGD. DR GO; GO:0007015; P:actin filament organization; ISO:RGD. DR GO; GO:0008306; P:associative learning; ISO:RGD. DR GO; GO:0048675; P:axon extension; ISO:RGD. DR GO; GO:0070830; P:bicellular tight junction assembly; ISO:RGD. DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; ISO:RGD. DR GO; GO:0060532; P:bronchus cartilage development; ISO:RGD. DR GO; GO:0060379; P:cardiac muscle cell myoblast differentiation; ISO:RGD. DR GO; GO:0055003; P:cardiac myofibril assembly; ISO:RGD. DR GO; GO:0060947; P:cardiac vascular smooth muscle cell differentiation; ISO:RGD. DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; ISO:RGD. DR GO; GO:0098609; P:cell-cell adhesion; ISO:RGD. DR GO; GO:0007160; P:cell-matrix adhesion; ISO:RGD. DR GO; GO:0071333; P:cellular response to glucose stimulus; IEP:RGD. DR GO; GO:0090398; P:cellular senescence; ISO:RGD. DR GO; GO:0030038; P:contractile actin filament bundle assembly; ISO:RGD. DR GO; GO:0048589; P:developmental growth; ISO:RGD. DR GO; GO:0035912; P:dorsal aorta morphogenesis; ISO:RGD. DR GO; GO:0090136; P:epithelial cell-cell adhesion; ISO:RGD. DR GO; GO:0010669; P:epithelial structure maintenance; ISO:RGD. DR GO; GO:0048821; P:erythrocyte development; ISO:RGD. DR GO; GO:0061436; P:establishment of skin barrier; ISO:RGD. DR GO; GO:0061029; P:eyelid development in camera-type eye; ISO:RGD. DR GO; GO:0060324; P:face development; ISO:RGD. DR GO; GO:0046847; P:filopodium assembly; ISO:RGD. DR GO; GO:0030900; P:forebrain development; ISO:RGD. DR GO; GO:0007369; P:gastrulation; ISO:RGD. DR GO; GO:0007507; P:heart development; ISO:RGD. DR GO; GO:0001947; P:heart looping; ISO:RGD. DR GO; GO:0060347; P:heart trabecula formation; ISO:RGD. DR GO; GO:0060218; P:hematopoietic stem cell differentiation; ISO:RGD. DR GO; GO:0021766; P:hippocampus development; ISO:RGD. DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD. DR GO; GO:0002521; P:leukocyte differentiation; ISO:RGD. DR GO; GO:0007616; P:long-term memory; IMP:RGD. DR GO; GO:0060292; P:long-term synaptic depression; ISO:RGD. DR GO; GO:0060425; P:lung morphogenesis; ISO:RGD. DR GO; GO:0061145; P:lung smooth muscle development; ISO:RGD. DR GO; GO:0035855; P:megakaryocyte development; ISO:RGD. DR GO; GO:0001707; P:mesoderm formation; ISO:RGD. DR GO; GO:0002011; P:morphogenesis of an epithelial sheet; ISO:RGD. DR GO; GO:0046716; P:muscle cell cellular homeostasis; ISO:RGD. DR GO; GO:1900222; P:negative regulation of amyloid-beta clearance; ISO:RGD. DR GO; GO:0030336; P:negative regulation of cell migration; IMP:RGD. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:RGD. DR GO; GO:1902894; P:negative regulation of miRNA transcription; ISO:RGD. DR GO; GO:0001764; P:neuron migration; ISO:RGD. DR GO; GO:0031175; P:neuron projection development; ISO:RGD. DR GO; GO:0030168; P:platelet activation; ISO:RGD. DR GO; GO:0030220; P:platelet formation; ISO:RGD. DR GO; GO:0045773; P:positive regulation of axon extension; ISO:RGD. DR GO; GO:0045597; P:positive regulation of cell differentiation; ISO:RGD. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IMP:RGD. DR GO; GO:0051491; P:positive regulation of filopodium assembly; ISO:RGD. DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:RGD. DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; ISO:RGD. DR GO; GO:0046016; P:positive regulation of transcription by glucose; IMP:RGD. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD. DR GO; GO:0060261; P:positive regulation of transcription initiation by RNA polymerase II; ISO:RGD. DR GO; GO:0045059; P:positive thymic T cell selection; ISO:RGD. DR GO; GO:0090009; P:primitive streak formation; ISO:RGD. DR GO; GO:0030155; P:regulation of cell adhesion; ISO:RGD. DR GO; GO:0006355; P:regulation of DNA-templated transcription; ISO:RGD. DR GO; GO:0034097; P:response to cytokine; ISO:RGD. DR GO; GO:0009725; P:response to hormone; ISO:RGD. DR GO; GO:0001666; P:response to hypoxia; ISO:RGD. DR GO; GO:0045214; P:sarcomere organization; ISO:RGD. DR GO; GO:0043589; P:skin morphogenesis; ISO:RGD. DR GO; GO:0043149; P:stress fiber assembly; ISO:RGD. DR GO; GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; ISO:RGD. DR GO; GO:0048538; P:thymus development; ISO:RGD. DR GO; GO:0030878; P:thyroid gland development; ISO:RGD. DR GO; GO:0060534; P:trachea cartilage development; ISO:RGD. DR GO; GO:0006366; P:transcription by RNA polymerase II; ISO:RGD. DR GO; GO:0001829; P:trophectodermal cell differentiation; ISO:RGD. DR CDD; cd00266; MADS_SRF_like; 1. DR Gene3D; 3.40.1810.10; Transcription factor, MADS-box; 1. DR InterPro; IPR033897; MADS_SRF-like. DR InterPro; IPR002100; TF_MADSbox. DR InterPro; IPR036879; TF_MADSbox_sf. DR PANTHER; PTHR48019:SF93; SERUM RESPONSE FACTOR; 1. DR PANTHER; PTHR48019; SERUM RESPONSE FACTOR HOMOLOG; 1. DR Pfam; PF00319; SRF-TF; 1. DR PRINTS; PR00404; MADSDOMAIN. DR SMART; SM00432; MADS; 1. DR SUPFAM; SSF55455; SRF-like; 1. DR PROSITE; PS00350; MADS_BOX_1; 1. DR PROSITE; PS50066; MADS_BOX_2; 1. PE 1: Evidence at protein level; KW Activator {ECO:0000256|ARBA:ARBA00023159}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. SQ SEQUENCE 504 AA; 51175 MW; 814091FD4CAF8918 CRC64; MLPSQAGAAA ALGRGSALGG SLNRTPTGRP GGSGGTRGAN GGRVPGNGAG LGPGRLEREA AAAAAPTAGA LYSGSEGDSE SGEEEELGAE RRGLKRSLSE MELGVVVGGP EAAAAAAGGY GPVSGAVSGA KPGKKTRGRV KIKMEFIDNK LRRYTTFSKR KTGIMKKAYE LSTLTGTQVL LLVASETGHV YTFATRKLQP MITSETGKAL IQTCLNSPDS PPRSDPSTDQ RMSATGFEEP DLTYQVSESD SSGETKDTLK PAFTVTNLPG TTSTIQTAPS TSTTMQVSSG PSFPITNYLA PVSASVSPSA VSSANGTVLK STGSGPVSSG GLMQLPTSFT LMPGGAVAQQ VPVQAIHVHQ APQQASPSRD SSTDLTQTSS SGTVTLPATI MTSSVPTTVG GHMMYPSPHA VMYAPTSGLA DGSLTVLNAF SQAPSTMQVS HSQVQEPGGV PQVFLTAPSG TVQIPVSAVQ LHQMAVIGQQ AGSSSNLTEL QVVNLDATHS TKSE //