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D3ZHH8

- D3ZHH8_RAT

UniProt

D3ZHH8 - D3ZHH8_RAT

Protein
Submitted name:

Protein Srf

Gene

Srf

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin DNA binding Source: Ensembl
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    4. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: Ensembl
    5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    6. RNA polymerase II transcription factor binding transcription factor activity Source: Ensembl
    7. sequence-specific DNA binding Source: RGD
    8. serum response element binding Source: Ensembl

    GO - Biological processi

    1. associative learning Source: Ensembl
    2. cardiac myofibril assembly Source: Ensembl
    3. cardiac vascular smooth muscle cell differentiation Source: Ensembl
    4. cell-matrix adhesion Source: Ensembl
    5. cell migration involved in sprouting angiogenesis Source: Ensembl
    6. cellular response to glucose stimulus Source: RGD
    7. cellular senescence Source: Ensembl
    8. contractile actin filament bundle assembly Source: Ensembl
    9. developmental growth Source: Ensembl
    10. dorsal aorta morphogenesis Source: Ensembl
    11. epithelial cell-cell adhesion Source: Ensembl
    12. epithelial structure maintenance Source: Ensembl
    13. erythrocyte development Source: Ensembl
    14. eyelid development in camera-type eye Source: Ensembl
    15. heart looping Source: Ensembl
    16. heart trabecula formation Source: Ensembl
    17. hematopoietic stem cell differentiation Source: Ensembl
    18. hippocampus development Source: Ensembl
    19. long-term memory Source: RGD
    20. long term synaptic depression Source: Ensembl
    21. megakaryocyte development Source: Ensembl
    22. mesoderm formation Source: Ensembl
    23. morphogenesis of an epithelial sheet Source: Ensembl
    24. mRNA transcription from RNA polymerase II promoter Source: Ensembl
    25. muscle cell cellular homeostasis Source: Ensembl
    26. negative regulation of beta-amyloid clearance Source: Ensembl
    27. negative regulation of cell migration Source: RGD
    28. negative regulation of cell proliferation Source: RGD
    29. neuron migration Source: Ensembl
    30. neuron projection development Source: Ensembl
    31. patterning of blood vessels Source: Ensembl
    32. platelet activation Source: Ensembl
    33. platelet formation Source: Ensembl
    34. positive regulation of cell differentiation Source: Ensembl
    35. positive regulation of filopodium assembly Source: Ensembl
    36. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    37. positive regulation of smooth muscle contraction Source: Ensembl
    38. positive regulation of transcription, DNA-templated Source: RGD
    39. positive regulation of transcription by glucose Source: RGD
    40. positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: Ensembl
    41. positive regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
    42. positive regulation of transcription via serum response element binding Source: Ensembl
    43. positive thymic T cell selection Source: Ensembl
    44. primitive streak formation Source: Ensembl
    45. regulation of cell adhesion Source: Ensembl
    46. regulation of water loss via skin Source: Ensembl
    47. response to cytokine Source: Ensembl
    48. response to hormone Source: Ensembl
    49. response to hypoxia Source: Ensembl
    50. sarcomere organization Source: Ensembl
    51. skin morphogenesis Source: Ensembl
    52. stress fiber assembly Source: Ensembl
    53. tangential migration from the subventricular zone to the olfactory bulb Source: Ensembl
    54. tight junction assembly Source: Ensembl
    55. trophectodermal cell differentiation Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein SrfImported
    Submitted name:
    Similar to serum response factor (Predicted)Imported
    Gene namesi
    Name:SrfImported
    Synonyms:RGD1559787_predictedImported
    ORF Names:rCG_43683Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1559787. Srf.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear chromatin Source: Ensembl
    3. nucleus Source: RGD

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    PTM / Processingi

    PTM databases

    PhosphoSiteiD3ZHH8.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 MADS-box domain.UniRule annotation
    Contains MADS-box domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00400000022158.
    KOiK04378.
    OMAiNAFPQAP.
    OrthoDBiEOG76DTVJ.
    TreeFamiTF318482.

    Family and domain databases

    InterProiIPR002100. TF_MADSbox.
    [Graphical view]
    PfamiPF00319. SRF-TF. 1 hit.
    [Graphical view]
    PRINTSiPR00404. MADSDOMAIN.
    SMARTiSM00432. MADS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55455. SSF55455. 1 hit.
    PROSITEiPS00350. MADS_BOX_1. 1 hit.
    PS50066. MADS_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3ZHH8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPSQAGAAA ALGRGSALGG SLNRTPTGRP GGSGGTRGAN GGRVPGNGAG    50
    LGPGRLEREA AAAAAPTAGA LYSGSEGDSE SGEEEELGAE RRGLKRSLSE 100
    MELGVVVGGP EAAAAAAGGY GPVSGAVSGA KPGKKTRGRV KIKMEFIDNK 150
    LRRYTTFSKR KTGIMKKAYE LSTLTGTQVL LLVASETGHV YTFATRKLQP 200
    MITSETGKAL IQTCLNSPDS PPRSDPSTDQ RMSATGFEEP DLTYQVSESD 250
    SSGETKDTLK PAFTVTNLPG TTSTIQTAPS TSTTMQVSSG PSFPITNYLA 300
    PVSASVSPSA VSSANGTVLK STGSGPVSSG GLMQLPTSFT LMPGGAVAQQ 350
    VPVQAIHVHQ APQQASPSRD SSTDLTQTSS SGTVTLPATI MTSSVPTTVG 400
    GHMMYPSPHA VMYAPTSGLA DGSLTVLNAF SQAPSTMQVS HSQVQEPGGV 450
    PQVFLTAPSG TVQIPVSAVQ LHQMAVIGQQ AGSSSNLTEL QVVNLDATHS 500
    TKSE 504
    Length:504
    Mass (Da):51,175
    Last modified:April 3, 2013 - v2
    Checksum:i814091FD4CAF8918
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06058796 Genomic DNA. No translation available.
    CH473987 Genomic DNA. Translation: EDM18828.1.
    RefSeqiNP_001102772.1. NM_001109302.1.
    XP_006244619.1. XM_006244557.1.
    UniGeneiRn.1501.

    Genome annotation databases

    EnsembliENSRNOT00000061430; ENSRNOP00000058149; ENSRNOG00000018232.
    GeneIDi501099.
    KEGGirno:501099.
    UCSCiRGD:1559787. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06058796 Genomic DNA. No translation available.
    CH473987 Genomic DNA. Translation: EDM18828.1 .
    RefSeqi NP_001102772.1. NM_001109302.1.
    XP_006244619.1. XM_006244557.1.
    UniGenei Rn.1501.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei D3ZHH8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000061430 ; ENSRNOP00000058149 ; ENSRNOG00000018232 .
    GeneIDi 501099.
    KEGGi rno:501099.
    UCSCi RGD:1559787. rat.

    Organism-specific databases

    CTDi 6722.
    RGDi 1559787. Srf.

    Phylogenomic databases

    GeneTreei ENSGT00400000022158.
    KOi K04378.
    OMAi NAFPQAP.
    OrthoDBi EOG76DTVJ.
    TreeFami TF318482.

    Miscellaneous databases

    NextBioi 35567571.
    PROi D3ZHH8.

    Family and domain databases

    InterProi IPR002100. TF_MADSbox.
    [Graphical view ]
    Pfami PF00319. SRF-TF. 1 hit.
    [Graphical view ]
    PRINTSi PR00404. MADSDOMAIN.
    SMARTi SM00432. MADS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55455. SSF55455. 1 hit.
    PROSITEi PS00350. MADS_BOX_1. 1 hit.
    PS50066. MADS_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD3ZHH8_RAT
    AccessioniPrimary (citable) accession number: D3ZHH8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 38 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3