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D3ZHH8

- D3ZHH8_RAT

UniProt

D3ZHH8 - D3ZHH8_RAT

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Protein
Submitted name: Protein Srf
Gene
Srf, RGD1559787_predicted, rCG_43683
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  3. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: Ensembl
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  5. RNA polymerase II transcription factor binding transcription factor activity Source: Ensembl
  6. chromatin DNA binding Source: Ensembl
  7. sequence-specific DNA binding Source: RGD
  8. serum response element binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. associative learning Source: Ensembl
  2. cardiac myofibril assembly Source: Ensembl
  3. cardiac vascular smooth muscle cell differentiation Source: Ensembl
  4. cell migration involved in sprouting angiogenesis Source: Ensembl
  5. cell-matrix adhesion Source: Ensembl
  6. cellular response to glucose stimulus Source: RGD
  7. cellular senescence Source: Ensembl
  8. contractile actin filament bundle assembly Source: Ensembl
  9. developmental growth Source: Ensembl
  10. dorsal aorta morphogenesis Source: Ensembl
  11. epithelial cell-cell adhesion Source: Ensembl
  12. epithelial structure maintenance Source: Ensembl
  13. erythrocyte development Source: Ensembl
  14. eyelid development in camera-type eye Source: Ensembl
  15. heart looping Source: Ensembl
  16. heart trabecula formation Source: Ensembl
  17. hematopoietic stem cell differentiation Source: Ensembl
  18. hippocampus development Source: Ensembl
  19. long term synaptic depression Source: Ensembl
  20. long-term memory Source: RGD
  21. mRNA transcription from RNA polymerase II promoter Source: Ensembl
  22. megakaryocyte development Source: Ensembl
  23. mesoderm formation Source: Ensembl
  24. morphogenesis of an epithelial sheet Source: Ensembl
  25. muscle cell cellular homeostasis Source: Ensembl
  26. negative regulation of beta-amyloid clearance Source: Ensembl
  27. negative regulation of cell migration Source: RGD
  28. negative regulation of cell proliferation Source: RGD
  29. neuron migration Source: Ensembl
  30. neuron projection development Source: Ensembl
  31. patterning of blood vessels Source: Ensembl
  32. platelet activation Source: Ensembl
  33. platelet formation Source: Ensembl
  34. positive regulation of cell differentiation Source: Ensembl
  35. positive regulation of filopodium assembly Source: Ensembl
  36. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  37. positive regulation of smooth muscle contraction Source: Ensembl
  38. positive regulation of transcription by glucose Source: RGD
  39. positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: Ensembl
  40. positive regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
  41. positive regulation of transcription via serum response element binding Source: Ensembl
  42. positive regulation of transcription, DNA-templated Source: RGD
  43. positive thymic T cell selection Source: Ensembl
  44. primitive streak formation Source: Ensembl
  45. regulation of cell adhesion Source: Ensembl
  46. regulation of water loss via skin Source: Ensembl
  47. response to cytokine Source: Ensembl
  48. response to hormone Source: Ensembl
  49. response to hypoxia Source: Ensembl
  50. sarcomere organization Source: Ensembl
  51. skin morphogenesis Source: Ensembl
  52. stress fiber assembly Source: Ensembl
  53. tangential migration from the subventricular zone to the olfactory bulb Source: Ensembl
  54. tight junction assembly Source: Ensembl
  55. trophectodermal cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Protein SrfImported
Submitted name:
Similar to serum response factor (Predicted)Imported
Gene namesi
Name:SrfImported
Synonyms:RGD1559787_predictedImported
ORF Names:rCG_43683Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1559787. Srf.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear chromatin Source: Ensembl
  3. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

PTM / Processingi

PTM databases

PhosphoSiteiD3ZHH8.

Family & Domainsi

Sequence similaritiesi

Contains 1 MADS-box domain.UniRule annotation
Contains MADS-box domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00400000022158.
KOiK04378.
OMAiNAFPQAP.
OrthoDBiEOG76DTVJ.
TreeFamiTF318482.

Family and domain databases

InterProiIPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZHH8-1 [UniParc]FASTAAdd to Basket

« Hide

MLPSQAGAAA ALGRGSALGG SLNRTPTGRP GGSGGTRGAN GGRVPGNGAG    50
LGPGRLEREA AAAAAPTAGA LYSGSEGDSE SGEEEELGAE RRGLKRSLSE 100
MELGVVVGGP EAAAAAAGGY GPVSGAVSGA KPGKKTRGRV KIKMEFIDNK 150
LRRYTTFSKR KTGIMKKAYE LSTLTGTQVL LLVASETGHV YTFATRKLQP 200
MITSETGKAL IQTCLNSPDS PPRSDPSTDQ RMSATGFEEP DLTYQVSESD 250
SSGETKDTLK PAFTVTNLPG TTSTIQTAPS TSTTMQVSSG PSFPITNYLA 300
PVSASVSPSA VSSANGTVLK STGSGPVSSG GLMQLPTSFT LMPGGAVAQQ 350
VPVQAIHVHQ APQQASPSRD SSTDLTQTSS SGTVTLPATI MTSSVPTTVG 400
GHMMYPSPHA VMYAPTSGLA DGSLTVLNAF SQAPSTMQVS HSQVQEPGGV 450
PQVFLTAPSG TVQIPVSAVQ LHQMAVIGQQ AGSSSNLTEL QVVNLDATHS 500
TKSE 504
Length:504
Mass (Da):51,175
Last modified:April 3, 2013 - v2
Checksum:i814091FD4CAF8918
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06058796 Genomic DNA. No translation available.
CH473987 Genomic DNA. Translation: EDM18828.1.
RefSeqiNP_001102772.1. NM_001109302.1.
XP_006244619.1. XM_006244557.1.
UniGeneiRn.1501.

Genome annotation databases

EnsembliENSRNOT00000061430; ENSRNOP00000058149; ENSRNOG00000018232.
GeneIDi501099.
KEGGirno:501099.
UCSCiRGD:1559787. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06058796 Genomic DNA. No translation available.
CH473987 Genomic DNA. Translation: EDM18828.1 .
RefSeqi NP_001102772.1. NM_001109302.1.
XP_006244619.1. XM_006244557.1.
UniGenei Rn.1501.

3D structure databases

ModBasei Search...

PTM databases

PhosphoSitei D3ZHH8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000061430 ; ENSRNOP00000058149 ; ENSRNOG00000018232 .
GeneIDi 501099.
KEGGi rno:501099.
UCSCi RGD:1559787. rat.

Organism-specific databases

CTDi 6722.
RGDi 1559787. Srf.

Phylogenomic databases

GeneTreei ENSGT00400000022158.
KOi K04378.
OMAi NAFPQAP.
OrthoDBi EOG76DTVJ.
TreeFami TF318482.

Miscellaneous databases

NextBioi 35567571.
PROi D3ZHH8.

Family and domain databases

InterProi IPR002100. TF_MADSbox.
[Graphical view ]
Pfami PF00319. SRF-TF. 1 hit.
[Graphical view ]
PRINTSi PR00404. MADSDOMAIN.
SMARTi SM00432. MADS. 1 hit.
[Graphical view ]
SUPFAMi SSF55455. SSF55455. 1 hit.
PROSITEi PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZHH8_RAT
AccessioniPrimary (citable) accession number: D3ZHH8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: September 3, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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