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Protein
Submitted name:

Eph receptor B3

Gene

Ephb3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei660ATPUniRule annotation1
Active sitei753Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi634 – 642ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2682334 EPH-Ephrin signaling
R-RNO-3928662 EPHB-mediated forward signaling
R-RNO-3928664 Ephrin signaling
R-RNO-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Submitted name:
Eph receptor B3Imported
Submitted name:
Eph receptor B3 (Predicted)Imported
Gene namesi
Name:Ephb3Imported
Synonyms:Ephb3_predictedImported
ORF Names:rCG_36502Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1305602 Ephb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei554 – 577HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501408763030 – 1048Sequence analysisAdd BLAST1019

Proteomic databases

PeptideAtlasiD3ZH39
PRIDEiD3ZH39

Expressioni

Gene expression databases

BgeeiENSRNOG00000031801

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039489

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 209Eph LBDInterPro annotationAdd BLAST179
Domaini331 – 446Fibronectin type-IIIInterPro annotationAdd BLAST116
Domaini447 – 540Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini628 – 891Protein kinaseInterPro annotationAdd BLAST264
Domaini920 – 984SAMInterPro annotationAdd BLAST65

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
KOiK05112
OMAiELAWTAH
OrthoDBiEOG091G00W0
TreeFamiTF315608

Family and domain databases

CDDicd10478 EphR_LBD_B3, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034245 EphB3_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZH39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGARPPPGL LPLLAPLLLP LLLPAGCRAL EETLMDTKWV TSELAWTSHP
60 70 80 90 100
ESGWEEVSGY DEAMNPIRTY QVCNVRESSQ NNWLRTGFIW RREVQRVYVE
110 120 130 140 150
LKFTVRDCNS IPNIPGSCKE TFNLFYYEAD SDVASASSPF WMENPYVKVD
160 170 180 190 200
TIAPDESFSR LDAGRVNTKV RSFGPLSKAG FYLAFQDQGA CMSLISVRAF
210 220 230 240 250
YKKCASTTAG FALFPETLTG AEPTSLVIAP GTCIANAVEV SVPLKLYCNG
260 270 280 290 300
DGEWMVPVGA CTCATGHEPA AKETQCRACP PGSYKAKQGE GPCLPCPPNS
310 320 330 340 350
RTTSPAASIC TCHNNFYRAD SDTADSACTT VPSPPRGVIS NVNETSLILE
360 370 380 390 400
WSEPRDLGGR DDLLYNVICK KCRGSSGAGG PATCSRCDDN VEFEPRQLGL
410 420 430 440 450
TERRVHISHL LAHTRYTFEV QAVNGVSGKS PLPPRYAAVN ITTNQAAPSE
460 470 480 490 500
VPTLHLHSSS GSSLTLSWAP PERPNGVILD YEMKYFEKSK GIASTVTSQK
510 520 530 540 550
NSVQLDGLQP DARYVVQVRA RTVAGYGQYS RPAEFETTSE RGSGAQQLQE
560 570 580 590 600
QLPLIVGSTV AGFVFMVVVV VIALVCLRKQ RQGPDAEYTE KLQQYVAPRM
610 620 630 640 650
KVYIDPFTYE DPNEAVREFA KEIDVSCVKI EEVIGAGEFG EVCRGRLKLP
660 670 680 690 700
GRREVFVAIK TLKVGYTERQ RRDFLSEASI MGQFDHPNII RLEGVVTKSR
710 720 730 740 750
PVMILTEFME NCALDSFLRL NDGQFTVIQL VGMLRGIAAG MKYLSEMNYV
760 770 780 790 800
HRDLAARNIL VNSNLVCKVS DFGLSRFLED DPSDPTYTSS LGGKIPIRWT
810 820 830 840 850
APEAIAYRKF TSASDVWSYG IVMWEVMSYG ERPYWDMSNQ DVINAVEQDY
860 870 880 890 900
RLPPPMDCPT ALHQLMLDCW VRDRNLRPKF SQIVNTLDKL IRNAASLKVI
910 920 930 940 950
ASAPSGMSQP LLDRTVPDYT TFTTVGDWLD AIKMGRYKES FVGAGFASFD
960 970 980 990 1000
LVAQMTAEDL LRIGVTLAGH QKKILSSIQD MRLQMNQTLP VQEVCPKPLH
1010 1020 1030 1040
IEDGLEEGVI SPPQMPQGPG LPALQSGIFT TQIWLCFSSG GPGRVGWG
Length:1,048
Mass (Da):115,537
Last modified:April 20, 2010 - v1
Checksum:i340974E05953244D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07034675 Genomic DNA No translation available.
CH473999 Genomic DNA Translation: EDL78031.1
RefSeqiNP_001099338.1, NM_001105868.1
UniGeneiRn.131133

Genome annotation databases

EnsembliENSRNOT00000044896; ENSRNOP00000039489; ENSRNOG00000031801
GeneIDi287989
KEGGirno:287989

Similar proteinsi

Entry informationi

Entry nameiD3ZH39_RAT
AccessioniPrimary (citable) accession number: D3ZH39
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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