ID   D3ZH34_RAT              Unreviewed;       446 AA.
AC   D3ZH34;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=polynucleotide adenylyltransferase {ECO:0000256|ARBA:ARBA00012388};
DE            EC=2.7.7.19 {ECO:0000256|ARBA:ARBA00012388};
GN   Name=Tent5a {ECO:0000313|Ensembl:ENSRNOP00000053775.2,
GN   ECO:0000313|RGD:1311381}; Synonyms=Fam46a {ECO:0000313|RGD:1311381};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000053775.2, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000053775.2, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000053775.2,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000053775.2}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000053775.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC         Evidence={ECO:0000256|ARBA:ARBA00029336};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11333;
CC         Evidence={ECO:0000256|ARBA:ARBA00029336};
CC   -!- SIMILARITY: Belongs to the TENT family.
CC       {ECO:0000256|ARBA:ARBA00007631}.
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DR   RefSeq; NP_001100314.1; NM_001106844.1.
DR   AlphaFoldDB; D3ZH34; -.
DR   SMR; D3ZH34; -.
DR   STRING; 10116.ENSRNOP00000053775; -.
DR   PhosphoSitePlus; D3ZH34; -.
DR   PaxDb; 10116-ENSRNOP00000053775; -.
DR   Ensembl; ENSRNOT00000056937.4; ENSRNOP00000053775.2; ENSRNOG00000010240.7.
DR   GeneID; 300870; -.
DR   KEGG; rno:300870; -.
DR   UCSC; RGD:1311381; rat.
DR   AGR; RGD:1311381; -.
DR   CTD; 55603; -.
DR   RGD; 1311381; Tent5a.
DR   eggNOG; KOG3852; Eukaryota.
DR   GeneTree; ENSGT00940000157191; -.
DR   HOGENOM; CLU_008115_2_1_1; -.
DR   OMA; CCENPTM; -.
DR   OrthoDB; 2946602at2759; -.
DR   TreeFam; TF315239; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000010240; Expressed in duodenum and 18 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:1990817; F:poly(A) RNA polymerase activity; ISO:RGD.
DR   GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR   GO; GO:0030501; P:positive regulation of bone mineralization; ISO:RGD.
DR   GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISO:RGD.
DR   GO; GO:0030278; P:regulation of ossification; ISO:RGD.
DR   GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR   InterPro; IPR012937; TET5.
DR   PANTHER; PTHR12974; PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44; 1.
DR   PANTHER; PTHR12974:SF25; TERMINAL NUCLEOTIDYLTRANSFERASE 5A; 1.
DR   Pfam; PF07984; NTP_transf_7; 1.
DR   SMART; SM01153; DUF1693; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ   SEQUENCE   446 AA;  50766 MW;  8B6761ABDB0FFF01 CRC64;
     MHQRYFWTDQ GQVAFGGHYM AESEGYFAMA EDELTGGPYI PLGGDFGGGG SFGDRCSDYC
     ESPTAHCNVL NWEQVQRLDG ILSETIPIHG RGNFPTLELQ PSLIVKVVRR RLEEKSIGVR
     DVRLNGSAAS HVLHQDSGLG YKDLDLIFCA DLRGEEEFQT VKDVVLDCLL DFLPEGVNKE
     KITPLTLKEA YVQKMVKVCN DSDRWSLISL SNNSGKNVEL KFVDSLRRQF EFSVDSFQIK
     LDSLLLFYEC SENPMTETFH PTIIGESVYG DFHEAFDHLC NKIIATRNPE EIRGGGLLKY
     CNLLVRGFRP ASEEIKTLQR YMCSRFFIDF SDIGEQQRKL ESYLQNHFVG LEDRKYDYLM
     TLHGVVNEST VCLMGHERRQ TLNLITMLAI RVLADQNVIP NVANVTCYYQ PAPYVADANF
     SNYYIAQVQP VFTCQQQTYS TWLPCN
//