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Protein

Sugar transporter SWEET1

Gene

Slc50a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar transporter SWEET1
Alternative name(s):
RAG1-activating protein 1
Solute carrier family 50 member 1
Gene namesi
Name:Slc50a1
Synonyms:Rag1ap1, Rga
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308478. Slc50a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei44 – 63Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei68 – 88Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei102 – 122Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei129 – 149Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei160 – 180Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei186 – 206Helical; Name=7Sequence analysisAdd BLAST21

GO - Cellular componenti

  • endomembrane system Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: GO_Central
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004054301 – 221Sugar transporter SWEET1Add BLAST221

Proteomic databases

PaxDbiD3ZH22.
PeptideAtlasiD3ZH22.
PRIDEiD3ZH22.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020554.
GenevisibleiD3ZH22. RN.

Interactioni

Subunit structurei

Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027878.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 94MtN3/slv 1Add BLAST85
Domaini127 – 212MtN3/slv 2Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 221Mediates interaction with TRPV21 PublicationAdd BLAST73

Sequence similaritiesi

Belongs to the SWEET sugar transporter family.Curated
Contains 2 MtN3/slv domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1623. Eukaryota.
ENOG4111M4R. LUCA.
GeneTreeiENSGT00390000007801.
InParanoidiD3ZH22.
KOiK15382.
OMAiINNLSWL.
OrthoDBiEOG091G0J82.
PhylomeDBiD3ZH22.
TreeFamiTF313635.

Family and domain databases

InterProiIPR004316. SWEET_sugar_transpr.
[Graphical view]
PfamiPF03083. MtN3_slv. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZH22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAGGVADSF LSSACVLFTL GMFSTGLSDL RHMQRTRSVD NIQFLPFLTT
60 70 80 90 100
DVNNLGWLSY GVLKGDGTLI IVNTVGAVLQ TLYILAYLHY SPQKHAVLLQ
110 120 130 140 150
TATLLAVLLL GYGYFWLLVP DLETRLQQLG LFCSVFTISM YLSPLADLAK
160 170 180 190 200
IIQTKSTQRL SFSLTIATLL SSTSWSIYGF RLKDPYITVP NLPGILTGFI
210 220
RLVLFYKYPP EQDTKYRLLQ T
Length:221
Mass (Da):24,694
Last modified:April 20, 2010 - v1
Checksum:i53B7483FBDA003E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473976 Genomic DNA. Translation: EDM00646.1.
RefSeqiNP_001099915.1. NM_001106445.1.
UniGeneiRn.823.

Genome annotation databases

EnsembliENSRNOT00000027878; ENSRNOP00000027878; ENSRNOG00000020554.
GeneIDi295245.
KEGGirno:295245.
UCSCiRGD:1308478. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473976 Genomic DNA. Translation: EDM00646.1.
RefSeqiNP_001099915.1. NM_001106445.1.
UniGeneiRn.823.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027878.

Proteomic databases

PaxDbiD3ZH22.
PeptideAtlasiD3ZH22.
PRIDEiD3ZH22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027878; ENSRNOP00000027878; ENSRNOG00000020554.
GeneIDi295245.
KEGGirno:295245.
UCSCiRGD:1308478. rat.

Organism-specific databases

CTDi55974.
RGDi1308478. Slc50a1.

Phylogenomic databases

eggNOGiKOG1623. Eukaryota.
ENOG4111M4R. LUCA.
GeneTreeiENSGT00390000007801.
InParanoidiD3ZH22.
KOiK15382.
OMAiINNLSWL.
OrthoDBiEOG091G0J82.
PhylomeDBiD3ZH22.
TreeFamiTF313635.

Enzyme and pathway databases

ReactomeiR-RNO-70153. Glucose transport.

Miscellaneous databases

PROiD3ZH22.

Gene expression databases

BgeeiENSRNOG00000020554.
GenevisibleiD3ZH22. RN.

Family and domain databases

InterProiIPR004316. SWEET_sugar_transpr.
[Graphical view]
PfamiPF03083. MtN3_slv. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWET1_RAT
AccessioniPrimary (citable) accession number: D3ZH22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.