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Protein

Tyrosine-protein kinase

Gene

LOC100909750

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • delta-catenin binding Source: RGD
  • non-membrane spanning protein tyrosine kinase activity Source: GO_Central
  • protein kinase activity Source: RGD
  • protein kinase binding Source: RGD

GO - Biological processi

  • actin filament polymerization Source: RGD
  • associative learning Source: RGD
  • cell differentiation Source: GO_Central
  • cellular response to oxidative stress Source: RGD
  • cellular response to transforming growth factor beta stimulus Source: RGD
  • glomerular visceral epithelial cell apoptotic process Source: RGD
  • innate immune response Source: GO_Central
  • learning or memory Source: RGD
  • peptidyl-tyrosine autophosphorylation Source: GO_Central
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of dendrite development Source: RGD
  • positive regulation of extracellular matrix organization Source: RGD
  • positive regulation of fibroblast proliferation Source: RGD
  • positive regulation of hydrogen peroxide-mediated programmed cell death Source: RGD
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of neuron death Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • protein autophosphorylation Source: RGD
  • regulation of cell proliferation Source: GO_Central
  • response to drug Source: RGD
  • response to endoplasmic reticulum stress Source: RGD
  • response to epinephrine Source: RGD
  • signal transduction in response to DNA damage Source: GO_Central
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-375170. CDO in myogenesis.
R-RNO-428890. Role of Abl in Robo-Slit signaling.
R-RNO-5663213. RHO GTPases Activate WASPs and WAVEs.
R-RNO-5685938. HDR through Single Strand Annealing (SSA).
R-RNO-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:LOC100909750Imported
Synonyms:Abl1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1584969. Abl1.
6502032. LOC100909750.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • endoplasmic reticulum Source: RGD
  • extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
  • growth cone Source: RGD
  • mitochondrion Source: RGD
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • nucleus Source: RGD
  • ruffle Source: RGD
  • synapse Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiD3ZGM3.
PeptideAtlasiD3ZGM3.

PTM databases

iPTMnetiD3ZGM3.
PhosphoSitePlusiD3ZGM3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009371.
ExpressionAtlasiD3ZGM3. baseline and differential.

Interactioni

GO - Molecular functioni

  • delta-catenin binding Source: RGD
  • protein kinase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012617.

Structurei

3D structure databases

ProteinModelPortaliD3ZGM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 121SH3InterPro annotationAdd BLAST61
Domaini127 – 217SH2InterPro annotationAdd BLAST91
Domaini242 – 493Protein kinaseInterPro annotationAdd BLAST252

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
InParanoidiD3ZGM3.
KOiK06619.
OMAiMASTECL.
OrthoDBiEOG091G0D46.
PhylomeDBiD3ZGM3.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR033221. ABL1.
IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF88. PTHR24418:SF88. 1 hit.
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZGM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS
60 70 80 90 100
KENLLAGPSE NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC
110 120 130 140 150
EAQTKNGQGW VPSNYITPVN SLEKHSWYHG PVSRNAAEYL LSSGINGSFL
160 170 180 190 200
VRESESSPGQ RSISLRYEGR VYHYRINTAS DGKLYVSSES RFNTLAELVH
210 220 230 240 250
HHSTVADGLI TTLHYPAPKR NKPTIYGVSP NYDKWEMERT DITMKHKLGG
260 270 280 290 300
GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ
310 320 330 340 350
LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVSAVVL LYMATQISSA
360 370 380 390 400
MEYLEKKNFI HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK
410 420 430 440 450
FPIKWTAPES LAYNKFSIKS DVWAFGVLLW EIATYGMSPY PGIDLSQVYE
460 470 480 490 500
LLEKDYRMER PEGCPEKVYE LMRACWQWNP SDRPSFAEIH QAFETMFQES
510 520 530 540 550
SISDEVEKEL GKRGMRGAAG STLQAPELPT KTRTCRKTAE QKDAPDALEL
560 570 580 590 600
LHTKGLGESD ALDSEPAVSP LLPRKERGPP DGSLNEDERL LPKDKKTNLF
610 620 630 640 650
SALIKKKKKM APTPPKRSSS FREMDGQSER RGASEDDGRE ISNGPPALTS
660 670 680 690 700
DAVEPTKSPK ASNGAGVPNG AFREPGNSGF RSPHVWKKSS TLTSSRLAAA
710 720 730 740 750
EEESGLSSSK RFLRSCSASC MPHGVRDTEW RSVTLPRDLP SAGKQFDSST
760 770 780 790 800
FGGHKSEKPA LPRKRTSESR SEQVAKSTAT PPPRLVKKTE EAAEDVFKDT
810 820 830 840 850
ESSPGSSPPS LTPKLLRRQV PASPSSGPSH KDEATKGNAS GMGTPATAEP
860 870 880 890 900
AAPSNKAGLS KASSEEPRAR RHKHSSESPG RDKGRLSKLK PAPPPPPSST
910 920 930 940 950
GKAGKPAQSP SQDVAGEAGG ATKTKCTSLS VDAVNSDPTK AGQPGEGLRK
960 970 980 990 1000
SVPPSVPKPQ SATKPPGTPT SPVSTPSTAP APSPLAGDQQ PSSAAFIPLI
1010 1020 1030 1040 1050
STRVSLRKTR QPPERIASGT ITKGVVLDST EALCLAISRN SEQMASHSAV
1060 1070 1080 1090 1100
LEAGKNLYTF CVSYVDSIQQ MRNKFAFREA INKLESNLRE LQICPATASS
1110 1120
GPAATQDFSK LLSSVKEISD IVRR
Length:1,124
Mass (Da):122,540
Last modified:April 20, 2010 - v1
Checksum:i70A3C45C06150E10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07051400 Genomic DNA. No translation available.
RefSeqiXP_003749487.1. XM_003749439.4.
XP_006233980.1. XM_006233918.3.
UniGeneiRn.3105.

Genome annotation databases

EnsembliENSRNOT00000012617; ENSRNOP00000012617; ENSRNOG00000009371.
GeneIDi100909750.
311860.
KEGGirno:100909750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07051400 Genomic DNA. No translation available.
RefSeqiXP_003749487.1. XM_003749439.4.
XP_006233980.1. XM_006233918.3.
UniGeneiRn.3105.

3D structure databases

ProteinModelPortaliD3ZGM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012617.

PTM databases

iPTMnetiD3ZGM3.
PhosphoSitePlusiD3ZGM3.

Proteomic databases

PaxDbiD3ZGM3.
PeptideAtlasiD3ZGM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012617; ENSRNOP00000012617; ENSRNOG00000009371.
GeneIDi100909750.
311860.
KEGGirno:100909750.

Organism-specific databases

CTDi25.
RGDi1584969. Abl1.
6502032. LOC100909750.

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
InParanoidiD3ZGM3.
KOiK06619.
OMAiMASTECL.
OrthoDBiEOG091G0D46.
PhylomeDBiD3ZGM3.

Enzyme and pathway databases

ReactomeiR-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-375170. CDO in myogenesis.
R-RNO-428890. Role of Abl in Robo-Slit signaling.
R-RNO-5663213. RHO GTPases Activate WASPs and WAVEs.
R-RNO-5685938. HDR through Single Strand Annealing (SSA).
R-RNO-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Gene expression databases

BgeeiENSRNOG00000009371.
ExpressionAtlasiD3ZGM3. baseline and differential.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR033221. ABL1.
IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF88. PTHR24418:SF88. 1 hit.
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZGM3_RAT
AccessioniPrimary (citable) accession number: D3ZGM3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.