ID D3ZG78_RAT Unreviewed; 2965 AA. AC D3ZG78; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 2. DT 27-MAR-2024, entry version 88. DE SubName: Full=Zinc finger ZZ-type and EF-hand domain containing 1 {ECO:0000313|Ensembl:ENSRNOP00000031588.5}; GN Name=Zzef1 {ECO:0000313|Ensembl:ENSRNOP00000031588.5, GN ECO:0000313|RGD:1311189}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000031588.5, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000031588.5, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000031588.5, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0007829|PubMed:22673903} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22673903; RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., RA Olsen J.V.; RT "Quantitative maps of protein phosphorylation sites across 14 different rat RT organs and tissues."; RL Nat. Commun. 3:876-876(2012). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000031588.5} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000031588.5}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006220785.1; XM_006220723.3. DR RefSeq; XP_006246919.1; XM_006246857.3. DR SMR; D3ZG78; -. DR STRING; 10116.ENSRNOP00000031588; -. DR jPOST; D3ZG78; -. DR PaxDb; 10116-ENSRNOP00000031588; -. DR PeptideAtlas; D3ZG78; -. DR Ensembl; ENSRNOT00000036278.7; ENSRNOP00000031588.5; ENSRNOG00000024535.7. DR GeneID; 287476; -. DR KEGG; rno:287476; -. DR AGR; RGD:1311189; -. DR CTD; 23140; -. DR RGD; 1311189; Zzef1. DR eggNOG; KOG1426; Eukaryota. DR GeneTree; ENSGT00940000155045; -. DR HOGENOM; CLU_000703_0_0_1; -. DR InParanoid; D3ZG78; -. DR OMA; RPTPPCE; -. DR OrthoDB; 2912853at2759; -. DR TreeFam; TF331572; -. DR Proteomes; UP000002494; Chromosome 10. DR Bgee; ENSRNOG00000024535; Expressed in jejunum and 18 other cell types or tissues. DR GO; GO:0009986; C:cell surface; ISO:RGD. DR GO; GO:0098794; C:postsynapse; ISO:RGD. DR GO; GO:0048786; C:presynaptic active zone; ISO:RGD. DR GO; GO:0045202; C:synapse; ISO:RGD. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0140566; F:histone reader activity; ISO:RGD. DR GO; GO:0070577; F:lysine-acetylated histone binding; ISO:RGD. DR GO; GO:0035064; F:methylated histone binding; ISO:RGD. DR GO; GO:0061659; F:ubiquitin-like protein ligase activity; ISO:RGD. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0007405; P:neuroblast proliferation; ISO:RGD. DR GO; GO:0016567; P:protein ubiquitination; ISO:RGD. DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; ISO:RGD. DR GO; GO:0048167; P:regulation of synaptic plasticity; ISO:RGD. DR GO; GO:0035249; P:synaptic transmission, glutamatergic; ISO:RGD. DR GO; GO:0008542; P:visual learning; ISO:RGD. DR CDD; cd08667; APC10-ZZEF1; 1. DR CDD; cd02249; ZZ; 1. DR CDD; cd02343; ZZ_EF; 1. DR Gene3D; 3.30.60.90; -; 2. DR Gene3D; 1.10.238.10; EF-hand; 1. DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1. DR InterPro; IPR004939; APC_su10/DOC_dom. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR008979; Galactose-bd-like_sf. DR InterPro; IPR000433; Znf_ZZ. DR InterPro; IPR043145; Znf_ZZ_sf. DR InterPro; IPR040099; ZZEF1. DR InterPro; IPR047052; ZZEF1_APC10. DR InterPro; IPR041986; ZZEF1_ZZ. DR PANTHER; PTHR22772; NOVEL ZZ TYPE ZINC FINGER DOMAIN CONTAINING PROTEIN; 1. DR PANTHER; PTHR22772:SF4; ZINC FINGER ZZ-TYPE AND EF-HAND DOMAIN-CONTAINING PROTEIN 1; 1. DR Pfam; PF03256; ANAPC10; 1. DR Pfam; PF00569; ZZ; 2. DR SMART; SM01337; APC10; 1. DR SMART; SM00054; EFh; 1. DR SMART; SM00291; ZnF_ZZ; 2. DR SUPFAM; SSF47473; EF-hand; 1. DR SUPFAM; SSF49785; Galactose-binding domain-like; 1. DR SUPFAM; SSF57850; RING/U-box; 2. DR PROSITE; PS51284; DOC; 1. DR PROSITE; PS50222; EF_HAND_2; 1. DR PROSITE; PS01357; ZF_ZZ_1; 1. DR PROSITE; PS50135; ZF_ZZ_2; 2. PE 1: Evidence at protein level; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Proteomics identification {ECO:0007829|PeptideAtlas:D3ZG78}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00228}. FT DOMAIN 111..146 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 226..405 FT /note="DOC" FT /evidence="ECO:0000259|PROSITE:PS51284" FT DOMAIN 1776..1831 FT /note="ZZ-type" FT /evidence="ECO:0000259|PROSITE:PS50135" FT DOMAIN 1825..1880 FT /note="ZZ-type" FT /evidence="ECO:0000259|PROSITE:PS50135" FT REGION 1..40 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1452..1530 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1986..2005 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2041..2081 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2428..2459 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1503..1517 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2439..2459 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 2965 AA; 332375 MW; 001408E5B6C17B92 CRC64; MGNAPSNSSE DEAAAAGGEG WSPHQDWAAD SGATPGPGPA AAVLPSAAAL LEPARLREAA AALRPAPPCE SLVSRHHGAL LRWLEERLGR GEESVTLEQF RELLEARGAG CSGEQFEEAF AQFDAEGDGT VDAENMLEAL KNSSGANLQG ELSHVIRQLQ ACSLVPGFID IFSESKEGLG THSSMILRFL HRNRVSSMVI PYPMLDHCNN MCTMRSSVLK DSLDQLLQKE KESPGDLARS PEMDKLKSVT KCYAYIETSS NPADIYRMTN GETSSYWQSD GSARSHWIRL KMKPDVVLRH LSIAVAATDQ SYMPQQVTVA VGRSASDLQE VRDVHIPSNV TGYVTLLENA NISQLYVQIN IKRCLSDGCD TRIHGLRAVG FQRVKKSGVS VSDASAIWYW SLLTSLVTAS METNPAFVQT VLHNTQKALQ HMPPLSLSPG STDFSTFLSP NVLEEVDSFL IRITSCCSTP EVELTLLAFA LARGSIAKVM SSLCAISDHL DTQYDASSLI SSMASVRQSL LLKYGKPLQL TLQACDVKGK EDKSGPENLL VEPWTRDGFL TETGKTRAST IFSAGTESAF QVTQIRIMVR RGGIGAQCGL VFAYNSPSDK FHAEEHFKRF EKYDRWKLQE LRQFVKSRIG CSPDDLGEDD PIGWFELEEE WDEADVKLQQ CRVAKFLMVK FLCTRQESAE RLGVQGLSIS GYLRPARAEA EQSILYAHCR RDTENIYGAT LLLRTLQFIQ QLAHDLVQQK ESGLKYKSFL DFAGLDLQIF WNFYSKLKQN PREECICAQT LLLQLLQSCF SVLQGDPQAV SEEEKPAAQR PEGIQAAKEL YTHLCDVVDR ADGESMPMEI LKQEVRNTLL NGAAIFFPDR QTRRNQLFTM MKNVTEHERK QSLQLTFRSL CTYFSDKDPG GLLLLPEKSD LATMNTSEVL AVMNTLLSVA ARECELLMLG RAHGEVGSVL FSLFWSVQGS LLSWCFLQLK STDAAAKELA MDLIEKYVGQ FLASMRVILE SLLSQYSGKT IVEKLCNSVF SMAARQLVIF LLDFCTLDVS HCTLLREFST LTELLKKLCS DPEGGLSKLD VETWQQEQPV VLHTWTKEST HNYENNCHEV SVFVSPGATY FEVEFDERCE TEKRYDYLEF TDSRGGKTRY DTKVGTYKWP KKVTFKDGPR LQFLFHSDSS NNEWGYKFTV TAYGLPDVAV SWGLDLQLLV SRLMGRLASQ CMALKSVHQL GSNLAISQAK LTAVLNSPLW KPVFRHQICP ELELEASWPT HPHQDGKEVK NIPDDPCRHF LLDFAQSEPA QNFCGPYSEL FKGFIQACRK QAPKTDIVAG STIDQAVNAT FAALVYRTPD LYEKLQKYVH SGGKIALPEE FSQVYSLADG IRIWMLEMKQ KSLVSMGNDS EEKRGLETAE VNPENLAKEC IQKSLLLLKF LPMSKSSKEN CDKLVPVDET DRLQPLDRRQ RTSSVVEEHF QGSASPTEAA TPAADDKSPG LEMQPKLLPS SGPSAAEVST AEEPSSPSTP TRRPPFTRGR LRLLSFRSME ETRPVPTVKE KYPVLKDVMD FIKDQSLSHE SIVKVLSLRK AQAQSILEVL RIIQYCTESL GQPHCFHPPY ILFLLELLTC QKDFTNYFGH LEGCGADLHK EIRDTYYQLV LFLVKAIKGF SSINDRSLLP AVSCVQTALL HLLDMGWEPS DLAFFVDIQL PDLLMNMSQE NISIHDSVIS QWSEEDELAD AKQNSEWMDE CQDGMFEAWY EKIAQEDPEK QRKMHMFIAR YCDLLNVDIS CDGCDEIAPW HRYRCLQCSD MDLCKTCFLG GVKPEGHGDD HEMVNMEFTC DHCQGLIIGR RMNCNVCDDF DLCYGCYAAK KYSYGHLPTH SITAHPMVTI RISDRQRFIQ PYIHNYSWLL FAALALYSAH LTSTEHVDGE QLDPQARGSA ATLRSQCMQL VGDCLMKAHQ GKGLKALALL GVLPDGDSTS ENQALPVTVS IQASEEQLEK KTAQPAEGPA DAGLFVPCNG KRATDKEVGP LDCKQKKKAG EDLSIMKDPS CQIQVSDPPA SDHVPPGLPD AEHPDRSSQA PMEEKAITPS PEQVFAECSQ KRILGLLAAM LPPIKSGPTV PLIDLEHVLP LMFQVVISNA GHLNETYHLT LGLLGQLIIR LQPAEVDAAV MKVLSAKHNL FATADNAVVP DGWKTTHLLF SLGAVCLDSR VGLDWACSMA EILRSLNNAP LWRDVIATFT DHCIKQLPFQ LKHTNIFTLL VLVGFPQVLC VGTRCVYMDN ANEPHNVIIL KHFTEKNRAV IVDVKTRKRK TVKDYQLVQK GGGQECGTSQ AQLSQYSQHF AFIASHLLQT SMDSHCPEAV EATWVLSLAL KGLYKTLKTH GFEETHATFL HTDLLKLLVK KCSKGTGFSK TWLLRDLEIL SIMLYSSKKE INTLTEHGDL ELDERGDQEE ELDRPVSSPG EAEQKKLDPL ESLDEPTRIC FLMAHDALNA PLHILRAIYE LQMKKTDSFF LEVQKRFDGD ELTTDERIRS LAQRWQPSRS LRLEEQSAKA VDTDMIILPC LSRPARSDQA TSESNPVTQK LISSTESELQ QSYAKQRRSK SAALLHKELN CKSKRAVRDY LFRVNEATAV LYARHVLASL LAEWPGHVPV SEDILELSGP AHMTYILDMF MQLEEKHQWE KILQKVLQGC RESMLGTMAL AACQFMEEPG MEVQVRESKH PYNNNTSFED KVHIPGAIYL SIKFDPQCNT EEGCDELAMS SSSDFQQDRH NFSGSQQKWK DFELPGDTLY YRFTSDMSNT EWGYRFTVTA GHLGRFQTGF EILKQMLSEE RVVPHLPLGK IWEWLVGVAC RQTGHQRLKA IHLLLRIVRC CSHSDLCDLG LLKPLWQLFT HMEYGLFEDV TQPGILLPLH RALTELFFVT ENRAQELGLL QEYLLALTTE DHLLRCAAQA LQNIAAISLA INYPNKATRL WNVEC //