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Protein

UbiA prenyltransferase domain-containing protein 1

Gene

Ubiad1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosyntetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (By similarity).By similarity

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Biological processi

Menaquinone biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-6806664. Metabolism of vitamin K.
UniPathwayiUPA00079.
UPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
UbiA prenyltransferase domain-containing protein 1 (EC:2.5.1.-)
Gene namesi
Name:Ubiad1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1309588. Ubiad1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei245 – 267HelicalSequence analysisAdd BLAST23
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004037832 – 338UbiA prenyltransferase domain-containing protein 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiD3ZG27.

PTM databases

iPTMnetiD3ZG27.
PhosphoSitePlusiD3ZG27.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009575.
GenevisibleiD3ZG27. RN.

Interactioni

Subunit structurei

Interacts with HMGCR and SOAT1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012691.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4581. Eukaryota.
COG1575. LUCA.
GeneTreeiENSGT00390000012439.
InParanoidiD3ZG27.
OMAiMGLFYVF.
OrthoDBiEOG091G0C2Z.
PhylomeDBiD3ZG27.
TreeFamiTF323238.

Family and domain databases

InterProiIPR000537. UbiA_prenyltransferase.
IPR026046. UBIAD1.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF005355. UBIAD1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZG27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVQAPGEK INIQAGETTQ VGDTDQQRND WPEEDRLPER SWRQKCASYV
60 70 80 90 100
LALRPWSFSA SLTPVALGSA LAYRSQGVLD PRLLLGCAVA VLAVHGAGNL
110 120 130 140 150
VNTYYDFSKG IDHKKSDDRT LVDRILEPQD VVRFGVFLYT LGCVCAAYLY
160 170 180 190 200
YLSTLKLEHL ALIYFGGLSG SFLYTGGIGF KYVALGDLVI LITFGPLAVM
210 220 230 240 250
FAYAVQVGSL AIFPLVYAIP LALSTEAILH SNNTRDMESD REAGIVTLAI
260 270 280 290 300
LIGPTLSYIL YNTLLFLPYL IFTILATHCS ISLALPLLTS PMAFSLERQF
310 320 330
RSQAFNKLPQ RTAKLNLLLG LFYVFGIILA PAGSLPRL
Length:338
Mass (Da):37,026
Last modified:April 20, 2010 - v1
Checksum:iCE818C5C7CD3DF9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA. Translation: EDL81120.1.
RefSeqiNP_001101463.1. NM_001107993.1.
UniGeneiRn.203344.

Genome annotation databases

EnsembliENSRNOT00000012692; ENSRNOP00000012691; ENSRNOG00000009575.
GeneIDi313706.
KEGGirno:313706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA. Translation: EDL81120.1.
RefSeqiNP_001101463.1. NM_001107993.1.
UniGeneiRn.203344.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012691.

PTM databases

iPTMnetiD3ZG27.
PhosphoSitePlusiD3ZG27.

Proteomic databases

PaxDbiD3ZG27.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012692; ENSRNOP00000012691; ENSRNOG00000009575.
GeneIDi313706.
KEGGirno:313706.

Organism-specific databases

CTDi29914.
RGDi1309588. Ubiad1.

Phylogenomic databases

eggNOGiKOG4581. Eukaryota.
COG1575. LUCA.
GeneTreeiENSGT00390000012439.
InParanoidiD3ZG27.
OMAiMGLFYVF.
OrthoDBiEOG091G0C2Z.
PhylomeDBiD3ZG27.
TreeFamiTF323238.

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA00232.
ReactomeiR-RNO-6806664. Metabolism of vitamin K.

Miscellaneous databases

PROiD3ZG27.

Gene expression databases

BgeeiENSRNOG00000009575.
GenevisibleiD3ZG27. RN.

Family and domain databases

InterProiIPR000537. UbiA_prenyltransferase.
IPR026046. UBIAD1.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF005355. UBIAD1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBIA1_RAT
AccessioniPrimary (citable) accession number: D3ZG27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.