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Protein

Tumor necrosis factor receptor superfamily member 21

Gene

Tnfrsf21

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation (By similarity). Negatively regulates oligodendrocyte survival, maturation and myelination.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Apoptosis, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 21
Alternative name(s):
Death receptor 6
CD_antigen: CD358
Gene namesi
Name:Tnfrsf21
Synonyms:Dr6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1307308. Tnfrsf21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 349308ExtracellularSequence analysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Topological domaini371 – 655285CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence analysisAdd
BLAST
Chaini42 – 655614Tumor necrosis factor receptor superfamily member 21PRO_0000425729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 80PROSITE-ProRule annotation
Disulfide bondi70 ↔ 88PROSITE-ProRule annotation
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi91 ↔ 106PROSITE-ProRule annotation
Disulfide bondi109 ↔ 123PROSITE-ProRule annotation
Disulfide bondi113 ↔ 131PROSITE-ProRule annotation
Disulfide bondi133 ↔ 144PROSITE-ProRule annotation
Disulfide bondi150 ↔ 168PROSITE-ProRule annotation
Disulfide bondi171 ↔ 186PROSITE-ProRule annotation
Disulfide bondi192 ↔ 211PROSITE-ProRule annotation
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence analysis
Lipidationi368 – 3681S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiD3ZF92.

Expressioni

Tissue specificityi

Detected in brain (at protein level). Detected in corpus callosum oligodendrocytes. Detected in embryonic and adult brain.1 Publication

Developmental stagei

Detected at low levels in embryonic brain. Expression is increased in newborns and during the first two weeks after birth. Expression decreases thereafter and is low after three weeks and in adult life.1 Publication

Gene expression databases

GenevisibleiD3ZF92. RN.

Interactioni

Subunit structurei

Associates with TRADD. Interacts with NGFR. Interacts with N-APP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015918.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 8839TNFR-Cys 1Add
BLAST
Repeati90 – 13142TNFR-Cys 2Add
BLAST
Repeati133 – 16735TNFR-Cys 3Add
BLAST
Repeati170 – 21142TNFR-Cys 4Add
BLAST
Domaini415 – 49884DeathPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHQ6. Eukaryota.
ENOG410YYKW. LUCA.
GeneTreeiENSGT00760000119204.
InParanoidiD3ZF92.
KOiK05157.
OMAiFSRPEHM.
OrthoDBiEOG786H2Q.
PhylomeDBiD3ZF92.
TreeFamiTF331157.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022330. TNFR_21.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01971. TNFACTORR21.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZF92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTSASSITA LASCSRIAGQ VGATMVAGSL LLLGFLSTIT AQPEQKTLSL
60 70 80 90 100
TGTYRHVDRT TGQVLTCDKC PAGTYVSEHC TNTSLRVCSS CPSGTFTRHE
110 120 130 140 150
NGIERCHDCS QPCPRPMIER LPCAALTDRE CICPPGMYQS NGTCAPHTVC
160 170 180 190 200
PVGWGVRKKG TENEDVRCKQ CARGTFSDVP SSVMKCRAHT DCLGQNLMVV
210 220 230 240 250
KQGTKETDNV CGVHLSSSST TPSSPGIATF SHPEHTESHD VPSSTYEPQG
260 270 280 290 300
MNSTDSNSTA SVRTKVPSDI QEETVPDNTS STSGKESTNR TLPNPPQLTH
310 320 330 340 350
QQGPHHRHIL KLLPSSMEAT GEKSSTAIKA PKRGHPRQNP HKHFDINEHL
360 370 380 390 400
PWMIVLFLLL VLVLIVVCSI RKSSRTLKKG PRQDPSAIME KAGLKKSLTP
410 420 430 440 450
TQNREKWIYY RNGHGIDILK LVAAQVGSQW KDIYQFLCNA SEREVAAFSN
460 470 480 490 500
GYTADHERAY AALQHWTIRG PEASLAQLIS ALRQHRRNDV VEKIRGLMED
510 520 530 540 550
TTQLETDKLA LPMSPSPLSP SPIPSPNVKL ENSTLLTVEP SPLDKNKGFF
560 570 580 590 600
VDESEPLLRC DSTSSGSSAL SRNGSFITKE KKDTVLRQVR LDPCDLQPIF
610 620 630 640 650
DDMLHILNPE ELRVIEEIPQ AEDKLDRLFE IIGVKSQEAS QTLLDSVYSH

LPDLL
Length:655
Mass (Da):71,870
Last modified:April 20, 2010 - v1
Checksum:i9CC872C9B4DB8CD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06058936 Genomic DNA. No translation available.
AABR06058937 Genomic DNA. No translation available.
CH473987 Genomic DNA. Translation: EDM18686.1.
RefSeqiNP_001101677.1. NM_001108207.1.
UniGeneiRn.98293.

Genome annotation databases

EnsembliENSRNOT00000015918; ENSRNOP00000015918; ENSRNOG00000011517.
GeneIDi316256.
KEGGirno:316256.
UCSCiRGD:1307308. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06058936 Genomic DNA. No translation available.
AABR06058937 Genomic DNA. No translation available.
CH473987 Genomic DNA. Translation: EDM18686.1.
RefSeqiNP_001101677.1. NM_001108207.1.
UniGeneiRn.98293.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015918.

Proteomic databases

PaxDbiD3ZF92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015918; ENSRNOP00000015918; ENSRNOG00000011517.
GeneIDi316256.
KEGGirno:316256.
UCSCiRGD:1307308. rat.

Organism-specific databases

CTDi27242.
RGDi1307308. Tnfrsf21.

Phylogenomic databases

eggNOGiENOG410IHQ6. Eukaryota.
ENOG410YYKW. LUCA.
GeneTreeiENSGT00760000119204.
InParanoidiD3ZF92.
KOiK05157.
OMAiFSRPEHM.
OrthoDBiEOG786H2Q.
PhylomeDBiD3ZF92.
TreeFamiTF331157.

Miscellaneous databases

NextBioi670650.
PROiD3ZF92.

Gene expression databases

GenevisibleiD3ZF92. RN.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022330. TNFR_21.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01971. TNFACTORR21.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination."
    Mi S., Lee X., Hu Y., Ji B., Shao Z., Yang W., Huang G., Walus L., Rhodes K., Gong B.J., Miller R.H., Pepinsky R.B.
    Nat. Med. 17:816-821(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTNR21_RAT
AccessioniPrimary (citable) accession number: D3ZF92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: April 20, 2010
Last modified: May 11, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.