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Protein

Sentrin-specific protease 7

Gene

Senp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei847By similarity1
Active sitei979By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC48.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 7 (EC:3.4.22.-)
Alternative name(s):
SUMO-1-specific protease 2
Sentrin/SUMO-specific protease SENP7
Gene namesi
Name:Senp7
Synonyms:Susp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1305510. Senp7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003955021 – 1037Sentrin-specific protease 7Add BLAST1037

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei25PhosphoserineBy similarity1
Modified residuei189PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZF42.
PeptideAtlasiD3ZF42.
PRIDEiD3ZF42.

PTM databases

iPTMnetiD3ZF42.
PhosphoSitePlusiD3ZF42.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001616.
GenevisibleiD3ZF42. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043376.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni747 – 971ProteaseBy similarityAdd BLAST225

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGiKOG0779. Eukaryota.
COG5160. LUCA.
GeneTreeiENSGT00530000063531.
InParanoidiD3ZF42.
KOiK08596.
OMAiVPKKMCK.
OrthoDBiEOG091G012K.
PhylomeDBiD3ZF42.
TreeFamiTF350136.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
[Graphical view]
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZF42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRARPGRRR ASSEIVTEGK RKKSSPADLQ KITKLLTVKS EDVLAQSPLP
60 70 80 90 100
KLRGSECWWT RSLRNKVICL DHKTTKAAHG CPPKALPKRH LKVMLTNVLW
110 120 130 140 150
TDLGREFRKT LPRNDAKLCD TSKVQSDSLP STSVDSIETC QRLDPLHQSL
160 170 180 190 200
NLSERIPRVI LTDIRQTELG RKYLKIPSVT EASLSDTASP KSEELSSSAD
210 220 230 240 250
GSLESCQNVN HLKSFLSERG SKPSRTGDIS AKEAANGRQE QGDDGDIAPE
260 270 280 290 300
MVTPQSKDFN SGNKGDYHEE GTSNKNTSYS HSETDHTPVS RKRKKRGRSN
310 320 330 340 350
FHNSHNPKSS VDKSTEYIKE EENESTVSSK LEESNEDSHQ DPAPPEGLTP
360 370 380 390 400
DSLETEATNV CSFVVQEPDV SAASGRACSP NKSSESSVSS EVAENSSAAE
410 420 430 440 450
KGEASTVKEA PPPGGNSEEN QLLMSAEPIV VSSDEEGPVE HKNSVILKLQ
460 470 480 490 500
PSQDYEFMSE NQTTSDPQLS ELMLGACESV QVSSELCPYN PDMENISCIN
510 520 530 540 550
PNSEMDLKLD FIFTCVYIGK IKGTSKGCIT FTKKYIKIPF QVSMNEISLT
560 570 580 590 600
VDTARLKRFG LWESKDDDHS KRSHAILFLW VSSNYLQDIQ TQLENPMLSQ
610 620 630 640 650
QSKANEFIFL ELNSPISQRE ELKLKDIMME IGATNGELQL SCPLPWVQAF
660 670 680 690 700
PLFQDLSPQE ISFLHYYCAS ASSFPAVAGA DMKKKPVSQP SNADVVKPTY
710 720 730 740 750
TFLHKQSSGC YSLSITSSPD EEWREVRNTG PVQKLIVYPP PPTKGGLGVT
760 770 780 790 800
NEDLECLEEG EFLNDVIIDF YLKYLLLEKA SDELVERSHI FSSFFYKCLT
810 820 830 840 850
RKENNLTEDN PDLSVAQRRH RRVRTWTRHI NIFNKDYIFV PVNESSHWYL
860 870 880 890 900
AVICFPWLEE AVYEDFPQTV SQEFQDQQSQ HDNKTIDNDP HTTSTVFTSA
910 920 930 940 950
EESQSTETSM SVPKKMCKRP CILILDSLKA ASIQNTVQNL REYLEVEWEV
960 970 980 990 1000
KRKTHREFSK TNMVDLCPKV PKQDNSSDCG VYLLQYVESF FQDPIVNFEL
1010 1020 1030
PIHLEKWFPR HVIKTKREDI RELILKLHLQ QQKGSSS
Length:1,037
Mass (Da):116,872
Last modified:April 20, 2010 - v1
Checksum:i945C78977051CA27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473967 Genomic DNA. Translation: EDM11051.1.
RefSeqiNP_001099358.1. NM_001105888.1.
UniGeneiRn.162010.

Genome annotation databases

EnsembliENSRNOT00000044177; ENSRNOP00000043376; ENSRNOG00000001616.
GeneIDi288167.
KEGGirno:288167.
UCSCiRGD:1305510. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473967 Genomic DNA. Translation: EDM11051.1.
RefSeqiNP_001099358.1. NM_001105888.1.
UniGeneiRn.162010.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043376.

Protein family/group databases

MEROPSiC48.009.

PTM databases

iPTMnetiD3ZF42.
PhosphoSitePlusiD3ZF42.

Proteomic databases

PaxDbiD3ZF42.
PeptideAtlasiD3ZF42.
PRIDEiD3ZF42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044177; ENSRNOP00000043376; ENSRNOG00000001616.
GeneIDi288167.
KEGGirno:288167.
UCSCiRGD:1305510. rat.

Organism-specific databases

CTDi57337.
RGDi1305510. Senp7.

Phylogenomic databases

eggNOGiKOG0779. Eukaryota.
COG5160. LUCA.
GeneTreeiENSGT00530000063531.
InParanoidiD3ZF42.
KOiK08596.
OMAiVPKKMCK.
OrthoDBiEOG091G012K.
PhylomeDBiD3ZF42.
TreeFamiTF350136.

Miscellaneous databases

PROiD3ZF42.

Gene expression databases

BgeeiENSRNOG00000001616.
GenevisibleiD3ZF42. RN.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
[Graphical view]
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSENP7_RAT
AccessioniPrimary (citable) accession number: D3ZF42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.