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Protein

Diacylglycerol kinase

Gene

Dgkq

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-114508 Effects of PIP2 hydrolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
Gene namesi
Name:DgkqImported
ORF Names:rCG_57232Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2320722 Dgkq

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiD3ZEY4

Expressioni

Gene expression databases

BgeeiENSRNOG00000024112

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036466

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 102Phorbol-ester/DAG-typeInterPro annotationAdd BLAST49
Domaini115 – 162Phorbol-ester/DAG-typeInterPro annotationAdd BLAST48
Domaini177 – 228Phorbol-ester/DAG-typeInterPro annotationAdd BLAST52
Domaini390 – 489Ras-associatingInterPro annotationAdd BLAST100
Domaini579 – 716DAGKcInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG1169 Eukaryota
ENOG410XQVB LUCA
GeneTreeiENSGT00760000119050
KOiK00901
OMAiTKPTFCH
OrthoDBiEOG091G02NN
TreeFamiTF312817

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR020454 DAG/PE-bd
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
IPR000159 RA_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
PF00788 RA, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 3 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit
PS50200 RA, 1 hit
PS00479 ZF_DAG_PE_1, 3 hits
PS50081 ZF_DAG_PE_2, 3 hits

Sequencei

Sequence statusi: Complete.

D3ZEY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAAESGAR TWPGSGSPRL GSPAGSPVLG ISGRARPGSG PERTGRAIGS
60 70 80 90 100
VAPGHSFRKV TLTKPTFCHL CSDFIWGLAG FLCDVCNFMS HEKCLKQVKT
110 120 130 140 150
PCTSIAPSLV RVPVAHCFGS LGLYKRKFCV VCRKSLEVPA FRCEVCELHV
160 170 180 190 200
HPDCVPFACS DCRQCHQDGQ HDYDTYHHHW REGNLPSGAR CEVCRKTCGS
210 220 230 240 250
SDVLAGVRCE WCGVQAHSVC STALTPECTF GRLRSMVLPP SCVRLLSRNF
260 270 280 290 300
SKMHCFRIPE TMVLELGDGD DGLDGSAAVG TGREVSAATE STKQTLKIFD
310 320 330 340 350
GNDSMRKNQF RLVTVSRLAR NEEVMEAALR AYYINEDPKD FQLQALPLTL
360 370 380 390 400
LSGNAQALGK AGTTEEETSK DSGPGDSVPE AWVIRSLPRT QEILKIYPDW
410 420 430 440 450
LKVGVAYVSI RVNSQSTARS VVQEVLPLFG RQVEDQERFQ LIEVLMSSRQ
460 470 480 490 500
VQRTVLVDEE PLLDRLRDIR QTSVRQASQT RFYVAEARAV TPHVSLFVGG
510 520 530 540 550
LPPGLSPQDY SNLLHEAMAT KAAVVSVSHV YSLQGAVVLD VTCFAEAERL
560 570 580 590 600
YMLARDTAVH GRPLTALVLP DVLHTKLPPD CCPLLVFVNP KSGGLKGREL
610 620 630 640 650
LCSFRKLLNP HQVFELTNGG PLPGFHLFSQ VPCFRVLVCG GDGTVGWVLA
660 670 680 690 700
ALEETRRHLA CPEPSVAILP LGTGNDLGRV LRWGAGYSGE DPFSVLVSVD
710 720 730 740 750
EADAVLMDRW TILLDAHEID STENNVVETE PPKIVQMNNY CGIGIDAELS
760 770 780 790 800
LDFHQAREEE PGKFTSRFHN KGVYVRVGLQ KISHSRSLHK EIRLQVEQQE
810 820 830 840 850
VELPSIEGLI FINIPSWGSG ADLWGSDSDS RFEKPRIDDG LLEVVGVTGV
860 870 880 890 900
VHMGQVQGGL RSGIRIAQGS YFRVTLLKAT PVQVDGEPWI QAPGHMIISA
910 920 930
TAPKVHMLRK AKQKPRKAGA IRDTRVDTLP APEGNPL
Length:937
Mass (Da):102,545
Last modified:April 20, 2010 - v1
Checksum:i9E0EAEAFD5A99716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117047 Genomic DNA No translation available.
CH474079 Genomic DNA Translation: EDL84024.1
RefSeqiNP_001185733.1, NM_001198804.1
UniGeneiRn.101434

Genome annotation databases

EnsembliENSRNOT00000032056; ENSRNOP00000036466; ENSRNOG00000024112
GeneIDi100361138
KEGGirno:100361138
UCSCiRGD:2320722 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZEY4_RAT
AccessioniPrimary (citable) accession number: D3ZEY4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health