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D3ZEY4

- D3ZEY4_RAT

UniProt

D3ZEY4 - D3ZEY4_RAT

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Protein

Diacylglycerol kinase

Gene

Dgkq

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. cAMP-mediated signaling Source: Ensembl
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
  3. protein kinase C signaling Source: Ensembl
  4. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. response to ATP Source: Ensembl
  6. thrombin receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
Gene namesi
Name:DgkqImported
ORF Names:rCG_57232Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 14

Organism-specific databases

RGDi2320722. Dgkq.

Subcellular locationi

GO - Cellular componenti

  1. cytoskeleton Source: Ensembl
  2. cytosol Source: Ensembl
  3. nuclear speck Source: Ensembl
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation
Contains 1 DAGKc domain.UniRule annotation
Contains 2 Ras-associating domains.UniRule annotation
Contains 3 phorbol-ester/DAG-type zinc fingers.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119050.
KOiK00901.
OMAiSDFIWGL.
OrthoDBiEOG71VSS6.
TreeFamiTF312817.

Family and domain databases

InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR020454. DAG/PE-bd.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR000159. Ras-assoc.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00788. RA. 2 hits.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 3 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
PS50200. RA. 1 hit.
PS00479. ZF_DAG_PE_1. 3 hits.
PS50081. ZF_DAG_PE_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZEY4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATAAESGAR TWPGSGSPRL GSPAGSPVLG ISGRARPGSG PERTGRAIGS
60 70 80 90 100
VAPGHSFRKV TLTKPTFCHL CSDFIWGLAG FLCDVCNFMS HEKCLKQVKT
110 120 130 140 150
PCTSIAPSLV RVPVAHCFGS LGLYKRKFCV VCRKSLEVPA FRCEVCELHV
160 170 180 190 200
HPDCVPFACS DCRQCHQDGQ HDYDTYHHHW REGNLPSGAR CEVCRKTCGS
210 220 230 240 250
SDVLAGVRCE WCGVQAHSVC STALTPECTF GRLRSMVLPP SCVRLLSRNF
260 270 280 290 300
SKMHCFRIPE TMVLELGDGD DGLDGSAAVG TGREVSAATE STKQTLKIFD
310 320 330 340 350
GNDSMRKNQF RLVTVSRLAR NEEVMEAALR AYYINEDPKD FQLQALPLTL
360 370 380 390 400
LSGNAQALGK AGTTEEETSK DSGPGDSVPE AWVIRSLPRT QEILKIYPDW
410 420 430 440 450
LKVGVAYVSI RVNSQSTARS VVQEVLPLFG RQVEDQERFQ LIEVLMSSRQ
460 470 480 490 500
VQRTVLVDEE PLLDRLRDIR QTSVRQASQT RFYVAEARAV TPHVSLFVGG
510 520 530 540 550
LPPGLSPQDY SNLLHEAMAT KAAVVSVSHV YSLQGAVVLD VTCFAEAERL
560 570 580 590 600
YMLARDTAVH GRPLTALVLP DVLHTKLPPD CCPLLVFVNP KSGGLKGREL
610 620 630 640 650
LCSFRKLLNP HQVFELTNGG PLPGFHLFSQ VPCFRVLVCG GDGTVGWVLA
660 670 680 690 700
ALEETRRHLA CPEPSVAILP LGTGNDLGRV LRWGAGYSGE DPFSVLVSVD
710 720 730 740 750
EADAVLMDRW TILLDAHEID STENNVVETE PPKIVQMNNY CGIGIDAELS
760 770 780 790 800
LDFHQAREEE PGKFTSRFHN KGVYVRVGLQ KISHSRSLHK EIRLQVEQQE
810 820 830 840 850
VELPSIEGLI FINIPSWGSG ADLWGSDSDS RFEKPRIDDG LLEVVGVTGV
860 870 880 890 900
VHMGQVQGGL RSGIRIAQGS YFRVTLLKAT PVQVDGEPWI QAPGHMIISA
910 920 930
TAPKVHMLRK AKQKPRKAGA IRDTRVDTLP APEGNPL
Length:937
Mass (Da):102,545
Last modified:April 20, 2010 - v1
Checksum:i9E0EAEAFD5A99716
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06077222 Genomic DNA. No translation available.
CH474079 Genomic DNA. Translation: EDL84024.1.
RefSeqiNP_001185733.1. NM_001198804.1.
UniGeneiRn.101434.

Genome annotation databases

EnsembliENSRNOT00000032056; ENSRNOP00000036466; ENSRNOG00000024112.
GeneIDi100361138.
KEGGirno:100361138.
UCSCiRGD:2320722. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06077222 Genomic DNA. No translation available.
CH474079 Genomic DNA. Translation: EDL84024.1 .
RefSeqi NP_001185733.1. NM_001198804.1.
UniGenei Rn.101434.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000032056 ; ENSRNOP00000036466 ; ENSRNOG00000024112 .
GeneIDi 100361138.
KEGGi rno:100361138.
UCSCi RGD:2320722. rat.

Organism-specific databases

CTDi 1609.
RGDi 2320722. Dgkq.

Phylogenomic databases

GeneTreei ENSGT00760000119050.
KOi K00901.
OMAi SDFIWGL.
OrthoDBi EOG71VSS6.
TreeFami TF312817.

Miscellaneous databases

NextBioi 34066233.
PROi D3ZEY4.

Family and domain databases

InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR020454. DAG/PE-bd.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR000159. Ras-assoc.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00788. RA. 2 hits.
[Graphical view ]
PRINTSi PR00008. DAGPEDOMAIN.
SMARTi SM00109. C1. 3 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00314. RA. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEi PS50146. DAGK. 1 hit.
PS50200. RA. 1 hit.
PS00479. ZF_DAG_PE_1. 3 hits.
PS50081. ZF_DAG_PE_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZEY4_RAT
AccessioniPrimary (citable) accession number: D3ZEY4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3