ERCC excision repair 2, TFIIH core complex helicase subunit

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 5'-3' DNA helicase activity Source: RGDInferred from sequence orthologyⁱ
  • 11445587
  • 8663148
• ATP binding Source: UniProtKB-KW
• ATP-dependent DNA helicase activity Source: InterPro
• DNA binding Source: InterPro
• protein C-terminus binding Source: RGDInferred from sequence orthologyⁱ
  • 10801852
• protein N-terminus binding Source: RGDInferred from sequence orthologyⁱ
  • 8652557
• RNA polymerase II carboxy-terminal domain kinase activity Source: Ensembl

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 25599822
• apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • 8675009
• bone mineralization Source: RGDInferred from sequence orthologyⁱ
  • 17020410
• cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • 17554309
• central nervous system myelin formation Source: RGDInferred from sequence orthologyⁱ
  • 17952069
• chromosome segregation Source: RGDInferred from sequence orthologyⁱ
  • 20797633
• DNA repair Source: RGDInferred from sequence orthologyⁱ
  • 11950998
• embryonic cleavage Source: RGDInferred from sequence orthologyⁱ
  • 9426063
• embryonic organ development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 11425516
• erythrocyte maturation Source: RGDInferred from sequence orthologyⁱ
  • 17020410
• extracellular matrix organization Source: RGDInferred from sequence orthologyⁱ
  • 9651581
• hair cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • 17020410
  • 11335038
• hair cycle process Source: RGDInferred from sequence orthologyⁱ
  • 17020410
• hair follicle maturation Source: RGDInferred from sequence orthologyⁱ
  • 9651581
• hematopoietic stem cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • 17554309
• in utero embryonic development Source: RGDInferred from sequence orthologyⁱ
  • 17020410
• multicellular organism growth Source: RGDInferred from sequence orthologyⁱ
  • 17020410
• nucleotide-excision repair Source: RGDInferred from sequence orthologyⁱ
  • 11950998
  • 9651581
  • 2835663
• nucleotide-excision repair, DNA incision Source: RGDInferred from sequence orthologyⁱ
  • 8692841
• positive regulation of DNA binding Source: RGDInferred from sequence orthologyⁱ
  • 17952069
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • 8692842
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • 8692841
• post-embryonic development Source: RGDInferred from sequence orthologyⁱ
  • 17020410
  • 11950998
• regulation of mitotic cell cycle phase transition Source: RGDInferred from sequence orthologyⁱ
  • 17088560
• response to hypoxia Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 9763211
• response to oxidative stress Source: RGDInferred from sequence orthologyⁱ
  • 11950998
  • 17614221
• response to UV Source: RGDInferred from sequence orthologyⁱ
  • 17020410
• skin development Source: RGDInferred from sequence orthologyⁱ
  • 17020410
  • 9651581
• spinal cord development Source: RGDInferred from sequence orthologyⁱ
  • 17020410
• transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • 9852112
• transcription-coupled nucleotide-excision repair Source: RGDInferred from sequence orthologyⁱ
  • 8663148
• UV protection Source: RGDInferred from sequence orthologyⁱ
  • 9651581
  • 2835663

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein C-terminus binding Source: RGDInferred from sequence orthologyⁱ
  • 10801852
• protein N-terminus binding Source: RGDInferred from sequence orthologyⁱ
  • 8652557

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV 
        60         70         80         90        100
SLLALIVAYQ RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LSFYEQQEGE 
       110        120        130        140        150
KLPFLGLALS SRKNLCIHPE VTPLRFGKDV DGKCHSLTAS YVRAQYQQDA 
       160        170        180        190        200
SLPHCRFYEE FDTHGRQVPL PAGIYNLDDL KALGQRQGWC PYFLARYSIL 
       210        220        230        240        250
HANVVVYSYH YLLDPKIADL VSKELARKAV VVFDEAHNID NVCIDSMSVN 
       260        270        280        290        300
LTRRTLDRCQ SNLDTLQKTV LRIKETDEQR LRDEYRRLVE GLREASAARE 
       310        320        330        340        350
TDAHLANPVL PDEVLQEAVP GSIRTAEHFL GFLRRLLEYV KWRLRVQHVV 
       360        370        380        390        400
QESPPAFLSG LAQRVCIQRK PLRFCAERLR SLLHTLEIAD LADFSPLTLL 
       410        420        430        440        450
ANFATLVSTY AKGFTIIIEP FDDRTPTITN PILHFSCMDA SLAIKPVFER 
       460        470        480        490        500
FQSVIITSGT LSPLDIYPKI LDFHPVTMAT FTMTLARVCL CPMIIGRGND 
       510        520        530        540        550
QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT SYQYMESTVA 
       560        570        580        590        600
SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA 
       610        620        630        640        650
RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARLEYL RDQFQIREND 
       660        670        680        690        700
FLTFDAMRHA AQCVGRAIRG KTDYGLMVFA DKRFARADKR GKLPRWIQEH 
       710        720        730        740        750
LTDSNLNLTV DEGVQVAKYF LRQMAQPFHR EDQLGLSLLS LEQLQSEETL 
       760
QRIEQIAQQL                                             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ