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D3ZEG9

- D3ZEG9_RAT

UniProt

D3ZEG9 - D3ZEG9_RAT

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Protein
Submitted name:

Protein Ercc2

Gene
Ercc2, rCG_54110
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotations

GO - Molecular functioni

  1. 5'-3' DNA helicase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. ATP-dependent DNA helicase activity Source: InterPro
  4. DNA binding Source: InterPro
  5. RNA polymerase II carboxy-terminal domain kinase activity Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. bone mineralization Source: Ensembl
  3. cell proliferation Source: Ensembl
  4. central nervous system myelin formation Source: Ensembl
  5. chromosome segregation Source: Ensembl
  6. embryonic cleavage Source: Ensembl
  7. erythrocyte maturation Source: Ensembl
  8. extracellular matrix organization Source: Ensembl
  9. hair cell differentiation Source: Ensembl
  10. hair follicle maturation Source: Ensembl
  11. hematopoietic stem cell differentiation Source: Ensembl
  12. in utero embryonic development Source: Ensembl
  13. multicellular organism growth Source: Ensembl
  14. nucleotide-excision repair, DNA incision Source: Ensembl
  15. positive regulation of DNA binding Source: Ensembl
  16. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  17. post-embryonic development Source: Ensembl
  18. regulation of mitotic cell cycle phase transition Source: Ensembl
  19. response to hypoxia Source: RGD
  20. response to oxidative stress Source: Ensembl
  21. spinal cord development Source: Ensembl
  22. transcription-coupled nucleotide-excision repair Source: Ensembl
  23. UV protection Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotations, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198290. Cytosolic iron-sulfur cluster assembly.
REACT_206206. RNA Polymerase I Transcription Initiation.
REACT_214635. Dual incision reaction in GG-NER.
REACT_216241. RNA Polymerase II Pre-transcription Events.
REACT_218876. RNA Polymerase I Promoter Escape.
REACT_219180. Formation of incision complex in GG-NER.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Ercc2Imported
Submitted name:
RCG54110Imported
Gene namesi
Name:Ercc2Imported
ORF Names:rCG_54110Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1309109. Ercc2.

Subcellular locationi

GO - Cellular componenti

  1. core TFIIH complex Source: RGD
  2. cyclin-dependent protein kinase activating kinase holoenzyme complex Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. MMXD complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains helicase ATP-binding domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00550000075092.
KOiK10844.
OMAiDEVWKYK.
OrthoDBiEOG70W3CM.
TreeFamiTF101232.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR010643. DUF1227.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
IPR001945. XPGD_DNA_repair.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF06777. DUF1227. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
PRINTSiPR00852. XRODRMPGMNTD.
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZEG9-1 [UniParc]FASTAAdd to Basket

« Hide

MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV    50
SLLALIVAYQ RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LSFYEQQEGE 100
KLPFLGLALS SRKNLCIHPE VTPLRFGKDV DGKCHSLTAS YVRAQYQQDA 150
SLPHCRFYEE FDTHGRQVPL PAGIYNLDDL KALGQRQGWC PYFLARYSIL 200
HANVVVYSYH YLLDPKIADL VSKELARKAV VVFDEAHNID NVCIDSMSVN 250
LTRRTLDRCQ SNLDTLQKTV LRIKETDEQR LRDEYRRLVE GLREASAARE 300
TDAHLANPVL PDEVLQEAVP GSIRTAEHFL GFLRRLLEYV KWRLRVQHVV 350
QESPPAFLSG LAQRVCIQRK PLRFCAERLR SLLHTLEIAD LADFSPLTLL 400
ANFATLVSTY AKGFTIIIEP FDDRTPTITN PILHFSCMDA SLAIKPVFER 450
FQSVIITSGT LSPLDIYPKI LDFHPVTMAT FTMTLARVCL CPMIIGRGND 500
QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT SYQYMESTVA 550
SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA 600
RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARLEYL RDQFQIREND 650
FLTFDAMRHA AQCVGRAIRG KTDYGLMVFA DKRFARADKR GKLPRWIQEH 700
LTDSNLNLTV DEGVQVAKYF LRQMAQPFHR EDQLGLSLLS LEQLQSEETL 750
QRIEQIAQQL 760
Length:760
Mass (Da):86,814
Last modified:April 20, 2010 - v1
Checksum:iAC4316E1F21BCF67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06003883 Genomic DNA. No translation available.
CH473979 Genomic DNA. Translation: EDM08205.1.
RefSeqiNP_001166280.1. NM_001172809.1.
UniGeneiRn.41871.

Genome annotation databases

EnsembliENSRNOT00000024246; ENSRNOP00000024247; ENSRNOG00000017753.
GeneIDi308415.
KEGGirno:308415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06003883 Genomic DNA. No translation available.
CH473979 Genomic DNA. Translation: EDM08205.1 .
RefSeqi NP_001166280.1. NM_001172809.1.
UniGenei Rn.41871.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024246 ; ENSRNOP00000024247 ; ENSRNOG00000017753 .
GeneIDi 308415.
KEGGi rno:308415.

Organism-specific databases

CTDi 2068.
RGDi 1309109. Ercc2.

Phylogenomic databases

GeneTreei ENSGT00550000075092.
KOi K10844.
OMAi DEVWKYK.
OrthoDBi EOG70W3CM.
TreeFami TF101232.

Enzyme and pathway databases

Reactomei REACT_198290. Cytosolic iron-sulfur cluster assembly.
REACT_206206. RNA Polymerase I Transcription Initiation.
REACT_214635. Dual incision reaction in GG-NER.
REACT_216241. RNA Polymerase II Pre-transcription Events.
REACT_218876. RNA Polymerase I Promoter Escape.
REACT_219180. Formation of incision complex in GG-NER.

Miscellaneous databases

NextBioi 658821.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR010643. DUF1227.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
IPR001945. XPGD_DNA_repair.
[Graphical view ]
Pfami PF06733. DEAD_2. 1 hit.
PF06777. DUF1227. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view ]
PRINTSi PR00852. XRODRMPGMNTD.
SMARTi SM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 4 hits.
TIGRFAMsi TIGR00604. rad3. 1 hit.
PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZEG9_RAT
AccessioniPrimary (citable) accession number: D3ZEG9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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