Ercc2

Functionⁱ

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.SAAS annotation

GO - Molecular functionⁱ

5'-3' DNA helicase activity Source: Ensembl
ATP binding Source: UniProtKB-KW
ATP-dependent DNA helicase activity Source: InterPro
DNA binding Source: InterPro
protein C-terminus binding Source: Ensembl
protein N-terminus binding Source: Ensembl
RNA polymerase II carboxy-terminal domain kinase activity Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

aging Source: Ensembl
apoptotic process Source: Ensembl
bone mineralization Source: Ensembl
cell proliferation Source: Ensembl
central nervous system myelin formation Source: Ensembl
chromosome segregation Source: Ensembl
embryonic cleavage Source: Ensembl
embryonic organ development
Source: RGD
Inferred from expression patternⁱ
- 11425516
erythrocyte maturation Source: Ensembl
extracellular matrix organization Source: Ensembl
hair cell differentiation Source: Ensembl
hair follicle maturation Source: Ensembl
hematopoietic stem cell differentiation Source: Ensembl
in utero embryonic development Source: Ensembl
multicellular organism growth Source: Ensembl
nucleotide-excision repair, DNA incision Source: Ensembl
positive regulation of DNA binding Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
post-embryonic development Source: Ensembl
regulation of mitotic cell cycle phase transition Source: Ensembl
response to hypoxia
Source: RGD
Inferred from expression patternⁱ
- 9763211
response to oxidative stress Source: Ensembl
spinal cord development Source: Ensembl
transcription-coupled nucleotide-excision repair Source: Ensembl
transcription from RNA polymerase II promoter Source: Ensembl
UV protection Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	HelicaseSAAS annotation, Hydrolase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-RNO-112382. Formation of RNA Pol II elongation complex. R-RNO-113418. Formation of the Early Elongation Complex. R-RNO-5696395. Formation of Incision Complex in GG-NER. R-RNO-5696400. Dual Incision in GG-NER. R-RNO-674695. RNA Polymerase II Pre-transcription Events. R-RNO-6781823. Formation of TC-NER Pre-Incision Complex. R-RNO-6782135. Dual incision in TC-NER. R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-RNO-72086. mRNA Capping. R-RNO-73762. RNA Polymerase I Transcription Initiation. R-RNO-73772. RNA Polymerase I Promoter Escape. R-RNO-73776. RNA Polymerase II Promoter Escape. R-RNO-73777. RNA Polymerase I Chain Elongation. R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-RNO-73863. RNA Polymerase I Transcription Termination. R-RNO-75953. RNA Polymerase II Transcription Initiation. R-RNO-75955. RNA Polymerase II Transcription Elongation. R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance. R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Reactomeⁱ

R-RNO-112382. Formation of RNA Pol II elongation complex.
R-RNO-113418. Formation of the Early Elongation Complex.
R-RNO-5696395. Formation of Incision Complex in GG-NER.
R-RNO-5696400. Dual Incision in GG-NER.
R-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.
R-RNO-6782135. Dual incision in TC-NER.
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-RNO-72086. mRNA Capping.
R-RNO-73762. RNA Polymerase I Transcription Initiation.
R-RNO-73772. RNA Polymerase I Promoter Escape.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73777. RNA Polymerase I Chain Elongation.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-73863. RNA Polymerase I Transcription Termination.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-75955. RNA Polymerase II Transcription Elongation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: ERCC excision repair 2, TFIIH core complex helicase subunitImported Submitted name: RCG54110Imported
Gene namesⁱ	Name:Ercc2Imported ORF Names:rCG_54110Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	1309109. Ercc2.

RGDⁱ

1309109. Ercc2.

Subcellular locationⁱ

Nucleus
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00553264

GO - Cellular componentⁱ

core TFIIH complex
Source: RGD
Inferred from direct assayⁱ
- 8855220
cyclin-dependent protein kinase activating kinase holoenzyme complex Source: Ensembl
cytosol Source: Ensembl
holo TFIIH complex Source: Ensembl
MMXD complex Source: Ensembl
transcription factor TFIID complex Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000017753.

Bgeeⁱ

ENSRNOG00000017753.

Interactionⁱ

GO - Molecular functionⁱ

protein C-terminus binding Source: Ensembl
protein N-terminus binding Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000024247.

STRINGⁱ

10116.ENSRNOP00000024247.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	7 – 283	Helicase ATP-bindingInterPro annotationAdd BLAST		277

Phylogenomic databases

eggNOGⁱ	KOG1131. Eukaryota. COG1199. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075092.
KEGG Orthology (KO) More...KOⁱ	K10844.
OMAⁱ	AQDAMEM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0262.
TreeFamⁱ	TF101232.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006555. ATP-dep_Helicase_C. IPR010614. DEAD_2. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR013020. DNA_helicase_DNA-repair_Rad3. IPR010643. HBB. IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3. IPR006554. Helicase-like_DEXD_c2. IPR027417. P-loop_NTPase. IPR001945. RAD3/XPD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06733. DEAD_2. 1 hit. PF06777. HBB. 1 hit. PF13307. Helicase_C_2. 1 hit.
PRINTSⁱ	PR00852. XRODRMPGMNTD.
SMARTⁱ	View protein in SMART SM00488. DEXDc2. 1 hit. SM00491. HELICc2. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 4 hits.
TIGRFAMsⁱ	TIGR00604. rad3. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00690. DEAH_ATP_HELICASE. 1 hit. PS51193. HELICASE_ATP_BIND_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

D3ZEG9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV 
        60         70         80         90        100
SLLALIVAYQ RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LSFYEQQEGE 
       110        120        130        140        150
KLPFLGLALS SRKNLCIHPE VTPLRFGKDV DGKCHSLTAS YVRAQYQQDA 
       160        170        180        190        200
SLPHCRFYEE FDTHGRQVPL PAGIYNLDDL KALGQRQGWC PYFLARYSIL 
       210        220        230        240        250
HANVVVYSYH YLLDPKIADL VSKELARKAV VVFDEAHNID NVCIDSMSVN 
       260        270        280        290        300
LTRRTLDRCQ SNLDTLQKTV LRIKETDEQR LRDEYRRLVE GLREASAARE 
       310        320        330        340        350
TDAHLANPVL PDEVLQEAVP GSIRTAEHFL GFLRRLLEYV KWRLRVQHVV 
       360        370        380        390        400
QESPPAFLSG LAQRVCIQRK PLRFCAERLR SLLHTLEIAD LADFSPLTLL 
       410        420        430        440        450
ANFATLVSTY AKGFTIIIEP FDDRTPTITN PILHFSCMDA SLAIKPVFER 
       460        470        480        490        500
FQSVIITSGT LSPLDIYPKI LDFHPVTMAT FTMTLARVCL CPMIIGRGND 
       510        520        530        540        550
QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT SYQYMESTVA 
       560        570        580        590        600
SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA 
       610        620        630        640        650
RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARLEYL RDQFQIREND 
       660        670        680        690        700
FLTFDAMRHA AQCVGRAIRG KTDYGLMVFA DKRFARADKR GKLPRWIQEH 
       710        720        730        740        750
LTDSNLNLTV DEGVQVAKYF LRQMAQPFHR EDQLGLSLLS LEQLQSEETL 
       760
QRIEQIAQQL

Length:760

Mass (Da):86,814

Last modified:April 20, 2010 - v1

Checksum:ⁱAC4316E1F21BCF67

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07002675 Genomic DNA. No translation available. AABR07002676 Genomic DNA. No translation available. CH473979 Genomic DNA. Translation: EDM08205.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001166280.1. NM_001172809.1.
UniGeneⁱ	Rn.41871.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000024246; ENSRNOP00000024247; ENSRNOG00000017753.
GeneIDⁱ	308415.
KEGGⁱ	rno:308415.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07002675 Genomic DNA. No translation available. AABR07002676 Genomic DNA. No translation available. CH473979 Genomic DNA. Translation: EDM08205.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001166280.1. NM_001172809.1.
UniGeneⁱ	Rn.41871.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000024247.

STRINGⁱ

10116.ENSRNOP00000024247.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000024246; ENSRNOP00000024247; ENSRNOG00000017753.
GeneIDⁱ	308415.
KEGGⁱ	rno:308415.

Organism-specific databases

CTDⁱ	2068.
Rat genome database More...RGDⁱ	1309109. Ercc2.

Phylogenomic databases

eggNOGⁱ	KOG1131. Eukaryota. COG1199. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075092.
KEGG Orthology (KO) More...KOⁱ	K10844.
OMAⁱ	AQDAMEM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0262.
TreeFamⁱ	TF101232.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-112382. Formation of RNA Pol II elongation complex. R-RNO-113418. Formation of the Early Elongation Complex. R-RNO-5696395. Formation of Incision Complex in GG-NER. R-RNO-5696400. Dual Incision in GG-NER. R-RNO-674695. RNA Polymerase II Pre-transcription Events. R-RNO-6781823. Formation of TC-NER Pre-Incision Complex. R-RNO-6782135. Dual incision in TC-NER. R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-RNO-72086. mRNA Capping. R-RNO-73762. RNA Polymerase I Transcription Initiation. R-RNO-73772. RNA Polymerase I Promoter Escape. R-RNO-73776. RNA Polymerase II Promoter Escape. R-RNO-73777. RNA Polymerase I Chain Elongation. R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-RNO-73863. RNA Polymerase I Transcription Termination. R-RNO-75953. RNA Polymerase II Transcription Initiation. R-RNO-75955. RNA Polymerase II Transcription Elongation. R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance. R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Reactomeⁱ

R-RNO-112382. Formation of RNA Pol II elongation complex.
R-RNO-113418. Formation of the Early Elongation Complex.
R-RNO-5696395. Formation of Incision Complex in GG-NER.
R-RNO-5696400. Dual Incision in GG-NER.
R-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.
R-RNO-6782135. Dual incision in TC-NER.
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-RNO-72086. mRNA Capping.
R-RNO-73762. RNA Polymerase I Transcription Initiation.
R-RNO-73772. RNA Polymerase I Promoter Escape.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73777. RNA Polymerase I Chain Elongation.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-73863. RNA Polymerase I Transcription Termination.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-75955. RNA Polymerase II Transcription Elongation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Gene expression databases

Bgeeⁱ	ENSRNOG00000017753.

Bgeeⁱ

ENSRNOG00000017753.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006555. ATP-dep_Helicase_C. IPR010614. DEAD_2. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR013020. DNA_helicase_DNA-repair_Rad3. IPR010643. HBB. IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3. IPR006554. Helicase-like_DEXD_c2. IPR027417. P-loop_NTPase. IPR001945. RAD3/XPD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06733. DEAD_2. 1 hit. PF06777. HBB. 1 hit. PF13307. Helicase_C_2. 1 hit.
PRINTSⁱ	PR00852. XRODRMPGMNTD.
SMARTⁱ	View protein in SMART SM00488. DEXDc2. 1 hit. SM00491. HELICc2. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 4 hits.
TIGRFAMsⁱ	TIGR00604. rad3. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00690. DEAH_ATP_HELICASE. 1 hit. PS51193. HELICASE_ATP_BIND_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZEG9_RAT
Accessionⁱ	D3ZEG9Primary (citable) accession number: D3ZEG9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	May 10, 2017
	This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3ZEG9 (D3ZEG9_RAT)

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ERCC excision repair 2, TFIIH core complex helicase subunit

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ