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D3ZEG9

- D3ZEG9_RAT

UniProt

D3ZEG9 - D3ZEG9_RAT

Protein
Submitted name:

Protein Ercc2

Gene

Ercc2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + H2O = ADP + phosphate.SAAS annotation

    GO - Molecular functioni

    1. 5'-3' DNA helicase activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. ATP-dependent DNA helicase activity Source: InterPro
    4. DNA binding Source: InterPro
    5. RNA polymerase II carboxy-terminal domain kinase activity Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. bone mineralization Source: Ensembl
    3. cell proliferation Source: Ensembl
    4. central nervous system myelin formation Source: Ensembl
    5. chromosome segregation Source: Ensembl
    6. embryonic cleavage Source: Ensembl
    7. erythrocyte maturation Source: Ensembl
    8. extracellular matrix organization Source: Ensembl
    9. hair cell differentiation Source: Ensembl
    10. hair follicle maturation Source: Ensembl
    11. hematopoietic stem cell differentiation Source: Ensembl
    12. in utero embryonic development Source: Ensembl
    13. multicellular organism growth Source: Ensembl
    14. nucleotide-excision repair, DNA incision Source: Ensembl
    15. positive regulation of DNA binding Source: Ensembl
    16. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    17. post-embryonic development Source: Ensembl
    18. regulation of mitotic cell cycle phase transition Source: Ensembl
    19. response to hypoxia Source: RGD
    20. response to oxidative stress Source: Ensembl
    21. spinal cord development Source: Ensembl
    22. transcription-coupled nucleotide-excision repair Source: Ensembl
    23. UV protection Source: Ensembl

    Keywords - Molecular functioni

    HelicaseSAAS annotation, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198290. Cytosolic iron-sulfur cluster assembly.
    REACT_206206. RNA Polymerase I Transcription Initiation.
    REACT_214635. Dual incision reaction in GG-NER.
    REACT_216241. RNA Polymerase II Pre-transcription Events.
    REACT_218876. RNA Polymerase I Promoter Escape.
    REACT_219180. Formation of incision complex in GG-NER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Ercc2Imported
    Submitted name:
    RCG54110Imported
    Gene namesi
    Name:Ercc2Imported
    ORF Names:rCG_54110Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1309109. Ercc2.

    Subcellular locationi

    GO - Cellular componenti

    1. core TFIIH complex Source: RGD
    2. cyclin-dependent protein kinase activating kinase holoenzyme complex Source: Ensembl
    3. cytoplasm Source: Ensembl
    4. MMXD complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains helicase ATP-binding domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000075092.
    KOiK10844.
    OMAiDEVWKYK.
    OrthoDBiEOG70W3CM.
    TreeFamiTF101232.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR006555. ATP-dep_Helicase_C.
    IPR010614. DEAD_2.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR013020. DNA_helicase_DNA-repair_Rad3.
    IPR010643. DUF1227.
    IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
    IPR006554. Helicase-like_DEXD_c2.
    IPR027417. P-loop_NTPase.
    IPR001945. XPGD_DNA_repair.
    [Graphical view]
    PfamiPF06733. DEAD_2. 1 hit.
    PF06777. DUF1227. 1 hit.
    PF13307. Helicase_C_2. 1 hit.
    [Graphical view]
    PRINTSiPR00852. XRODRMPGMNTD.
    SMARTiSM00488. DEXDc2. 1 hit.
    SM00491. HELICc2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 4 hits.
    TIGRFAMsiTIGR00604. rad3. 1 hit.
    PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51193. HELICASE_ATP_BIND_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3ZEG9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV    50
    SLLALIVAYQ RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LSFYEQQEGE 100
    KLPFLGLALS SRKNLCIHPE VTPLRFGKDV DGKCHSLTAS YVRAQYQQDA 150
    SLPHCRFYEE FDTHGRQVPL PAGIYNLDDL KALGQRQGWC PYFLARYSIL 200
    HANVVVYSYH YLLDPKIADL VSKELARKAV VVFDEAHNID NVCIDSMSVN 250
    LTRRTLDRCQ SNLDTLQKTV LRIKETDEQR LRDEYRRLVE GLREASAARE 300
    TDAHLANPVL PDEVLQEAVP GSIRTAEHFL GFLRRLLEYV KWRLRVQHVV 350
    QESPPAFLSG LAQRVCIQRK PLRFCAERLR SLLHTLEIAD LADFSPLTLL 400
    ANFATLVSTY AKGFTIIIEP FDDRTPTITN PILHFSCMDA SLAIKPVFER 450
    FQSVIITSGT LSPLDIYPKI LDFHPVTMAT FTMTLARVCL CPMIIGRGND 500
    QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT SYQYMESTVA 550
    SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA 600
    RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARLEYL RDQFQIREND 650
    FLTFDAMRHA AQCVGRAIRG KTDYGLMVFA DKRFARADKR GKLPRWIQEH 700
    LTDSNLNLTV DEGVQVAKYF LRQMAQPFHR EDQLGLSLLS LEQLQSEETL 750
    QRIEQIAQQL 760
    Length:760
    Mass (Da):86,814
    Last modified:April 20, 2010 - v1
    Checksum:iAC4316E1F21BCF67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06003883 Genomic DNA. No translation available.
    CH473979 Genomic DNA. Translation: EDM08205.1.
    RefSeqiNP_001166280.1. NM_001172809.1.
    UniGeneiRn.41871.

    Genome annotation databases

    EnsembliENSRNOT00000024246; ENSRNOP00000024247; ENSRNOG00000017753.
    GeneIDi308415.
    KEGGirno:308415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06003883 Genomic DNA. No translation available.
    CH473979 Genomic DNA. Translation: EDM08205.1 .
    RefSeqi NP_001166280.1. NM_001172809.1.
    UniGenei Rn.41871.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024246 ; ENSRNOP00000024247 ; ENSRNOG00000017753 .
    GeneIDi 308415.
    KEGGi rno:308415.

    Organism-specific databases

    CTDi 2068.
    RGDi 1309109. Ercc2.

    Phylogenomic databases

    GeneTreei ENSGT00550000075092.
    KOi K10844.
    OMAi DEVWKYK.
    OrthoDBi EOG70W3CM.
    TreeFami TF101232.

    Enzyme and pathway databases

    Reactomei REACT_198290. Cytosolic iron-sulfur cluster assembly.
    REACT_206206. RNA Polymerase I Transcription Initiation.
    REACT_214635. Dual incision reaction in GG-NER.
    REACT_216241. RNA Polymerase II Pre-transcription Events.
    REACT_218876. RNA Polymerase I Promoter Escape.
    REACT_219180. Formation of incision complex in GG-NER.

    Miscellaneous databases

    NextBioi 658821.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR006555. ATP-dep_Helicase_C.
    IPR010614. DEAD_2.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR013020. DNA_helicase_DNA-repair_Rad3.
    IPR010643. DUF1227.
    IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
    IPR006554. Helicase-like_DEXD_c2.
    IPR027417. P-loop_NTPase.
    IPR001945. XPGD_DNA_repair.
    [Graphical view ]
    Pfami PF06733. DEAD_2. 1 hit.
    PF06777. DUF1227. 1 hit.
    PF13307. Helicase_C_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00852. XRODRMPGMNTD.
    SMARTi SM00488. DEXDc2. 1 hit.
    SM00491. HELICc2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 4 hits.
    TIGRFAMsi TIGR00604. rad3. 1 hit.
    PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51193. HELICASE_ATP_BIND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD3ZEG9_RAT
    AccessioniPrimary (citable) accession number: D3ZEG9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3