Ercc2

Functionⁱ

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.SAAS annotation

Enzyme and pathway databases

Reactomeⁱ	R-RNO-112382. Formation of RNA Pol II elongation complex. R-RNO-113418. Formation of the Early Elongation Complex. R-RNO-5696395. Formation of Incision Complex in GG-NER. R-RNO-5696400. Dual Incision in GG-NER. R-RNO-674695. RNA Polymerase II Pre-transcription Events. R-RNO-6781823. Formation of TC-NER Pre-Incision Complex. R-RNO-6782135. Dual incision in TC-NER. R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-RNO-72086. mRNA Capping. R-RNO-73762. RNA Polymerase I Transcription Initiation. R-RNO-73772. RNA Polymerase I Promoter Escape. R-RNO-73776. RNA Polymerase II Promoter Escape. R-RNO-73777. RNA Polymerase I Chain Elongation. R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-RNO-73863. RNA Polymerase I Transcription Termination. R-RNO-75953. RNA Polymerase II Transcription Initiation. R-RNO-75955. RNA Polymerase II Transcription Elongation. R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance. R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Reactomeⁱ

R-RNO-112382. Formation of RNA Pol II elongation complex.
R-RNO-113418. Formation of the Early Elongation Complex.
R-RNO-5696395. Formation of Incision Complex in GG-NER.
R-RNO-5696400. Dual Incision in GG-NER.
R-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.
R-RNO-6782135. Dual incision in TC-NER.
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-RNO-72086. mRNA Capping.
R-RNO-73762. RNA Polymerase I Transcription Initiation.
R-RNO-73772. RNA Polymerase I Promoter Escape.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73777. RNA Polymerase I Chain Elongation.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-73863. RNA Polymerase I Transcription Termination.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-75955. RNA Polymerase II Transcription Elongation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Protein Ercc2Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSRNOP00000024247 Submitted name: RCG54110Imported Automatic assertion inferred from database entriesⁱ EMBL:EDM08205.1
Gene namesⁱ	Name:Ercc2Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSRNOP00000024247 RGD:1309109 ORF Names:rCG_54110Imported Automatic assertion inferred from database entriesⁱ EMBL:EDM08205.1
Organismⁱ	Rattus norvegicus (Rat)Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSRNOP00000024247 Proteomes:UP000002494
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

RGDⁱ	1309109. Ercc2.

Subcellular locationⁱ

Nucleus
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00553264

GO - Cellular componentⁱ

core TFIIH complex
Source: RGD
Inferred from direct assayⁱ
- 8855220
cyclin-dependent protein kinase activating kinase holoenzyme complex Source: Ensembl
cytoplasm Source: Ensembl
holo TFIIH complex Source: Ensembl
MMXD complex Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusSAAS annotation

PTM / Processingⁱ

PTM databases

PhosphoSiteⁱ	D3ZEG9.

PhosphoSiteⁱ

D3ZEG9.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000017753.

Bgeeⁱ

ENSRNOG00000017753.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000024247.

STRINGⁱ

10116.ENSRNOP00000024247.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	7 – 283	277	Helicase ATP-bindingInterPro annotation Automatic assertion inferred from signature matchⁱ PROSITE:PS51193			Add BLAST

Sequence similaritiesⁱ

Contains helicase ATP-binding domain.SAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG1131. Eukaryota. COG1199. LUCA.
GeneTreeⁱ	ENSGT00550000075092.
KOⁱ	K10844.
OMAⁱ	AQDAMEM.
OrthoDBⁱ	EOG091G0262.
TreeFamⁱ	TF101232.

Family and domain databases

Gene3Dⁱ	3.40.50.300. 2 hits.
InterProⁱ	IPR006555. ATP-dep_Helicase_C. IPR010614. DEAD_2. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR013020. DNA_helicase_DNA-repair_Rad3. IPR010643. HBB. IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3. IPR006554. Helicase-like_DEXD_c2. IPR027417. P-loop_NTPase. IPR001945. RAD3/XPD. [Graphical view]
Pfamⁱ	PF06733. DEAD_2. 1 hit. PF06777. HBB. 1 hit. PF13307. Helicase_C_2. 1 hit. [Graphical view]
PRINTSⁱ	PR00852. XRODRMPGMNTD.
SMARTⁱ	SM00488. DEXDc2. 1 hit. SM00491. HELICc2. 1 hit. [Graphical view]
SUPFAMⁱ	SSF52540. SSF52540. 4 hits.
TIGRFAMsⁱ	TIGR00604. rad3. 1 hit.
PROSITEⁱ	PS00690. DEAH_ATP_HELICASE. 1 hit. PS51193. HELICASE_ATP_BIND_2. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

D3ZEG9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV 
        60         70         80         90        100
SLLALIVAYQ RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LSFYEQQEGE 
       110        120        130        140        150
KLPFLGLALS SRKNLCIHPE VTPLRFGKDV DGKCHSLTAS YVRAQYQQDA 
       160        170        180        190        200
SLPHCRFYEE FDTHGRQVPL PAGIYNLDDL KALGQRQGWC PYFLARYSIL 
       210        220        230        240        250
HANVVVYSYH YLLDPKIADL VSKELARKAV VVFDEAHNID NVCIDSMSVN 
       260        270        280        290        300
LTRRTLDRCQ SNLDTLQKTV LRIKETDEQR LRDEYRRLVE GLREASAARE 
       310        320        330        340        350
TDAHLANPVL PDEVLQEAVP GSIRTAEHFL GFLRRLLEYV KWRLRVQHVV 
       360        370        380        390        400
QESPPAFLSG LAQRVCIQRK PLRFCAERLR SLLHTLEIAD LADFSPLTLL 
       410        420        430        440        450
ANFATLVSTY AKGFTIIIEP FDDRTPTITN PILHFSCMDA SLAIKPVFER 
       460        470        480        490        500
FQSVIITSGT LSPLDIYPKI LDFHPVTMAT FTMTLARVCL CPMIIGRGND 
       510        520        530        540        550
QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT SYQYMESTVA 
       560        570        580        590        600
SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA 
       610        620        630        640        650
RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARLEYL RDQFQIREND 
       660        670        680        690        700
FLTFDAMRHA AQCVGRAIRG KTDYGLMVFA DKRFARADKR GKLPRWIQEH 
       710        720        730        740        750
LTDSNLNLTV DEGVQVAKYF LRQMAQPFHR EDQLGLSLLS LEQLQSEETL 
       760
QRIEQIAQQL

Length:760

Mass (Da):86,814

Last modified:April 20, 2010 - v1

Checksum:ⁱAC4316E1F21BCF67

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07002675 Genomic DNA. No translation available. AABR07002676 Genomic DNA. No translation available. CH473979 Genomic DNA. Translation: EDM08205.1.
RefSeqⁱ	NP_001166280.1. NM_001172809.1.
UniGeneⁱ	Rn.41871.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000024246; ENSRNOP00000024247; ENSRNOG00000017753.
GeneIDⁱ	308415.
KEGGⁱ	rno:308415.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07002675 Genomic DNA. No translation available. AABR07002676 Genomic DNA. No translation available. CH473979 Genomic DNA. Translation: EDM08205.1.
RefSeqⁱ	NP_001166280.1. NM_001172809.1.
UniGeneⁱ	Rn.41871.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000024247.

STRINGⁱ

10116.ENSRNOP00000024247.

PTM databases

PhosphoSiteⁱ	D3ZEG9.

PhosphoSiteⁱ

D3ZEG9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000024246; ENSRNOP00000024247; ENSRNOG00000017753.
GeneIDⁱ	308415.
KEGGⁱ	rno:308415.

Organism-specific databases

CTDⁱ	2068.
RGDⁱ	1309109. Ercc2.

Phylogenomic databases

eggNOGⁱ	KOG1131. Eukaryota. COG1199. LUCA.
GeneTreeⁱ	ENSGT00550000075092.
KOⁱ	K10844.
OMAⁱ	AQDAMEM.
OrthoDBⁱ	EOG091G0262.
TreeFamⁱ	TF101232.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-112382. Formation of RNA Pol II elongation complex. R-RNO-113418. Formation of the Early Elongation Complex. R-RNO-5696395. Formation of Incision Complex in GG-NER. R-RNO-5696400. Dual Incision in GG-NER. R-RNO-674695. RNA Polymerase II Pre-transcription Events. R-RNO-6781823. Formation of TC-NER Pre-Incision Complex. R-RNO-6782135. Dual incision in TC-NER. R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-RNO-72086. mRNA Capping. R-RNO-73762. RNA Polymerase I Transcription Initiation. R-RNO-73772. RNA Polymerase I Promoter Escape. R-RNO-73776. RNA Polymerase II Promoter Escape. R-RNO-73777. RNA Polymerase I Chain Elongation. R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-RNO-73863. RNA Polymerase I Transcription Termination. R-RNO-75953. RNA Polymerase II Transcription Initiation. R-RNO-75955. RNA Polymerase II Transcription Elongation. R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance. R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Reactomeⁱ

R-RNO-112382. Formation of RNA Pol II elongation complex.
R-RNO-113418. Formation of the Early Elongation Complex.
R-RNO-5696395. Formation of Incision Complex in GG-NER.
R-RNO-5696400. Dual Incision in GG-NER.
R-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.
R-RNO-6782135. Dual incision in TC-NER.
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-RNO-72086. mRNA Capping.
R-RNO-73762. RNA Polymerase I Transcription Initiation.
R-RNO-73772. RNA Polymerase I Promoter Escape.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73777. RNA Polymerase I Chain Elongation.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-73863. RNA Polymerase I Transcription Termination.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-75955. RNA Polymerase II Transcription Elongation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Gene expression databases

Bgeeⁱ	ENSRNOG00000017753.

Bgeeⁱ

ENSRNOG00000017753.

Family and domain databases

Gene3Dⁱ	3.40.50.300. 2 hits.
InterProⁱ	IPR006555. ATP-dep_Helicase_C. IPR010614. DEAD_2. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR013020. DNA_helicase_DNA-repair_Rad3. IPR010643. HBB. IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3. IPR006554. Helicase-like_DEXD_c2. IPR027417. P-loop_NTPase. IPR001945. RAD3/XPD. [Graphical view]
Pfamⁱ	PF06733. DEAD_2. 1 hit. PF06777. HBB. 1 hit. PF13307. Helicase_C_2. 1 hit. [Graphical view]
PRINTSⁱ	PR00852. XRODRMPGMNTD.
SMARTⁱ	SM00488. DEXDc2. 1 hit. SM00491. HELICc2. 1 hit. [Graphical view]
SUPFAMⁱ	SSF52540. SSF52540. 4 hits.
TIGRFAMsⁱ	TIGR00604. rad3. 1 hit.
PROSITEⁱ	PS00690. DEAH_ATP_HELICASE. 1 hit. PS51193. HELICASE_ATP_BIND_2. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

D3ZEG9_RAT

Accessionⁱ

Primary (citable) accession number: D3ZEG9

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3ZEG9 (D3ZEG9_RAT)

UniProt

D3ZEG9 - D3ZEG9_RAT

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Protein Ercc2

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ