UniProtKB - D3ZEG9 (D3ZEG9_RAT)
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Protein
Submitted name:
ERCC excision repair 2, TFIIH core complex helicase subunit
Gene
Ercc2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
ATP + H2O = ADP + phosphate.SAAS annotation
GO - Molecular functioni
- 5'-3' DNA helicase activity Source: RGD
- ATP binding Source: UniProtKB-KW
- ATP-dependent DNA helicase activity Source: InterPro
- DNA binding Source: InterPro
- protein C-terminus binding Source: RGD
- protein N-terminus binding Source: RGD
- RNA polymerase II carboxy-terminal domain kinase activity Source: Ensembl
GO - Biological processi
- aging Source: RGD
- apoptotic process Source: RGD
- bone mineralization Source: RGD
- cell proliferation Source: RGD
- central nervous system myelin formation Source: RGD
- chromosome segregation Source: RGD
- DNA repair Source: RGD
- embryonic cleavage Source: RGD
- embryonic organ development Source: RGD
- erythrocyte maturation Source: RGD
- extracellular matrix organization Source: RGD
- hair cell differentiation Source: RGD
- hair cycle process Source: RGD
- hair follicle maturation Source: RGD
- hematopoietic stem cell differentiation Source: RGD
- in utero embryonic development Source: RGD
- multicellular organism growth Source: RGD
- nucleotide-excision repair Source: RGD
- nucleotide-excision repair, DNA incision Source: RGD
- positive regulation of DNA binding Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- post-embryonic development Source: RGD
- regulation of mitotic cell cycle phase transition Source: RGD
- response to hypoxia Source: RGD
- response to oxidative stress Source: RGD
- response to UV Source: RGD
- skin development Source: RGD
- spinal cord development Source: RGD
- transcription by RNA polymerase II Source: RGD
- transcription-coupled nucleotide-excision repair Source: RGD
- UV protection Source: RGD
Keywordsi
Molecular function | HelicaseSAAS annotation, Hydrolase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-112382. Formation of RNA Pol II elongation complex. R-RNO-113418. Formation of the Early Elongation Complex. R-RNO-5696395. Formation of Incision Complex in GG-NER. R-RNO-5696400. Dual Incision in GG-NER. R-RNO-674695. RNA Polymerase II Pre-transcription Events. R-RNO-6781823. Formation of TC-NER Pre-Incision Complex. R-RNO-6782135. Dual incision in TC-NER. R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-RNO-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-RNO-72086. mRNA Capping. R-RNO-73762. RNA Polymerase I Transcription Initiation. R-RNO-73772. RNA Polymerase I Promoter Escape. R-RNO-73776. RNA Polymerase II Promoter Escape. R-RNO-73777. RNA Polymerase I Chain Elongation. R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-RNO-73863. RNA Polymerase I Transcription Termination. R-RNO-75953. RNA Polymerase II Transcription Initiation. R-RNO-75955. RNA Polymerase II Transcription Elongation. R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance. R-RNO-77075. RNA Pol II CTD phosphorylation and interaction with CE. |
Names & Taxonomyi
Protein namesi | Submitted name: ERCC excision repair 2, TFIIH core complex helicase subunitImportedSubmitted name: RCG54110Imported |
Gene namesi | Name:Ercc2Imported ORF Names:rCG_54110Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309109. Ercc2. |
Interactioni
GO - Molecular functioni
- protein C-terminus binding Source: RGD
- protein N-terminus binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024247. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 283 | Helicase ATP-bindingInterPro annotationAdd BLAST | 277 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 77 – 97 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 256 – 276 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1131. Eukaryota. COG1199. LUCA. |
GeneTreei | ENSGT00550000075092. |
KOi | K10844. |
OMAi | PSVVRNY. |
OrthoDBi | EOG091G0262. |
TreeFami | TF101232. |
Family and domain databases
InterProi | View protein in InterPro IPR006555. ATP-dep_Helicase_C. IPR010614. DEAD_2. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR010643. HBB. IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3. IPR006554. Helicase-like_DEXD_c2. IPR027417. P-loop_NTPase. IPR013020. Rad3/Chl1-like. IPR001945. RAD3/XPD. |
PANTHERi | PTHR11472:SF1. PTHR11472:SF1. 1 hit. |
Pfami | View protein in Pfam PF06733. DEAD_2. 1 hit. PF06777. HBB. 1 hit. PF13307. Helicase_C_2. 1 hit. |
PRINTSi | PR00852. XRODRMPGMNTD. |
SMARTi | View protein in SMART SM00488. DEXDc2. 1 hit. SM00491. HELICc2. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 4 hits. |
TIGRFAMsi | TIGR00604. rad3. 1 hit. |
PROSITEi | View protein in PROSITE PS00690. DEAH_ATP_HELICASE. 1 hit. PS51193. HELICASE_ATP_BIND_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
D3ZEG9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV
60 70 80 90 100
SLLALIVAYQ RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LSFYEQQEGE
110 120 130 140 150
KLPFLGLALS SRKNLCIHPE VTPLRFGKDV DGKCHSLTAS YVRAQYQQDA
160 170 180 190 200
SLPHCRFYEE FDTHGRQVPL PAGIYNLDDL KALGQRQGWC PYFLARYSIL
210 220 230 240 250
HANVVVYSYH YLLDPKIADL VSKELARKAV VVFDEAHNID NVCIDSMSVN
260 270 280 290 300
LTRRTLDRCQ SNLDTLQKTV LRIKETDEQR LRDEYRRLVE GLREASAARE
310 320 330 340 350
TDAHLANPVL PDEVLQEAVP GSIRTAEHFL GFLRRLLEYV KWRLRVQHVV
360 370 380 390 400
QESPPAFLSG LAQRVCIQRK PLRFCAERLR SLLHTLEIAD LADFSPLTLL
410 420 430 440 450
ANFATLVSTY AKGFTIIIEP FDDRTPTITN PILHFSCMDA SLAIKPVFER
460 470 480 490 500
FQSVIITSGT LSPLDIYPKI LDFHPVTMAT FTMTLARVCL CPMIIGRGND
510 520 530 540 550
QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT SYQYMESTVA
560 570 580 590 600
SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA
610 620 630 640 650
RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARLEYL RDQFQIREND
660 670 680 690 700
FLTFDAMRHA AQCVGRAIRG KTDYGLMVFA DKRFARADKR GKLPRWIQEH
710 720 730 740 750
LTDSNLNLTV DEGVQVAKYF LRQMAQPFHR EDQLGLSLLS LEQLQSEETL
760
QRIEQIAQQL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07002675 Genomic DNA. No translation available. AABR07002676 Genomic DNA. No translation available. CH473979 Genomic DNA. Translation: EDM08205.1. |
RefSeqi | NP_001166280.1. NM_001172809.1. |
UniGenei | Rn.41871. |
Genome annotation databases
Ensembli | ENSRNOT00000024246; ENSRNOP00000024247; ENSRNOG00000017753. |
GeneIDi | 308415. |
KEGGi | rno:308415. |
Similar proteinsi
Entry informationi
Entry namei | D3ZEG9_RAT | |
Accessioni | D3ZEG9Primary (citable) accession number: D3ZEG9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | March 28, 2018 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |