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Protein

Histone-lysine N-methyltransferase

Gene

Kmt5a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-2299718 Condensation of Prophase Chromosomes
R-RNO-3214841 PKMTs methylate histone lysines
R-RNO-6804760 Regulation of TP53 Activity through Methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:Kmt5aImported
Synonyms:LOC100909949Imported, Pr-set7Imported, Setd8Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1587560 Kmt5a

Expressioni

Gene expression databases

BgeeiENSRNOG00000001062

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062763

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 307SETInterPro annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 198S-adenosyl-L-methionine bindingUniRule annotation3
Regioni268 – 269S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1085 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00410000025501
KOiK11428
OMAiKQFSRGE
OrthoDBiEOG091G0UBI

Family and domain databases

InterProiView protein in InterPro
IPR016858 Hist_H4-K20_MeTrfase
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
PIRSFiPIRSF027717 Histone_H4-K20_mtfrase, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS51571 SAM_MT43_PR_SET, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZEB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVERRGPGRP RSDGENVFAG QSKIYAYMSP NKCSGMRSPL QEENSVAHHE
60 70 80 90 100
VKCPGKPLAG IYRKREEKRN AGNVIRSAVK SEEQKSKDTR RGPLAPFPNQ
110 120 130 140 150
KPEATEPPKT PPPSCDSTSV AVAKQALKKP LKGKQAPRKK SQGKTQQNRK
160 170 180 190 200
LTDFYPVRRS SRKSKAELQS EERKKIDELI ESGKEEGMKI DLIDGKGRGV
210 220 230 240 250
IATKRFSRGD FVVEYHGDLI EITDAKKREA LYAQDPSTGC YMYYFQYLSK
260 270 280 290 300
TYCVDATQET NRLGRLINHS KCGNCQTKLH DIDGVPHLIL IASRDIAAGE
310 320
ELLYDYGDRS KASIEAYPWL KH
Length:322
Mass (Da):36,216
Last modified:April 3, 2013 - v2
Checksum:iBB07F0BC32F9A066
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07036310 Genomic DNA No translation available.
AABR07072291 Genomic DNA No translation available.
AB606422 mRNA Translation: BAK43219.1
RefSeqiNP_001233594.1, NM_001246665.1
UniGeneiRn.8879

Genome annotation databases

EnsembliENSRNOT00000066253; ENSRNOP00000062763; ENSRNOG00000001062
GeneIDi689820
KEGGirno:689820
UCSCiRGD:1587560 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZEB9_RAT
AccessioniPrimary (citable) accession number: D3ZEB9
Secondary accession number(s): F7J138
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: May 23, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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