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Protein
Submitted name:

Eph receptor A1 (Predicted)

Gene

Epha1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei657 – 6571ATPUniRule annotation
Active sitei750 – 7501Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi631 – 6399ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2682334. EPH-Ephrin signaling.
R-RNO-3928663. EPHA-mediated growth cone collapse.
R-RNO-3928665. EPH-ephrin mediated repulsion of cells.

Names & Taxonomyi

Protein namesi
Submitted name:
Eph receptor A1 (Predicted)Imported
Submitted name:
Protein Epha1Imported
Gene namesi
Name:Epha1Imported
Synonyms:Epha1_predictedImported
ORF Names:rCG_28177Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1304680. Epha1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei549 – 56921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 977951Sequence analysisPRO_5007912645Add
BLAST

PTM databases

PhosphoSiteiD3ZDH4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017525.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024037.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 210183Eph LBD (Eph ligand-binding)InterPro annotationAdd
BLAST
Domaini333 – 446114Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini448 – 53992Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini625 – 885261Protein kinaseInterPro annotationAdd
BLAST
Domaini914 – 97764SAM (sterile alpha motif)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains SAM (sterile alpha motif) domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
KOiK05102.
OMAiQAYEDPA.
OrthoDBiEOG091G00W0.
TreeFamiTF315363.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZDH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRWPLGLA LLLLLLCAPL PPGARAEEVT LMDTSTAQGE LGWLLDPPET
60 70 80 90 100
GWSEVQQMLN GTPLYMYQDC PIQEGGDTDH WLRSNWIYRG EEASRVHVEL
110 120 130 140 150
QFTVRDCKSF PGGAGPLGCK ETFNLFYMES DQDVGIQLRR PLFQKVTTVA
160 170 180 190 200
ADQSFTIRDL ASGSVKLNVE HCSLGHLTRR GLYLAFHNPG SCVALVSVRV
210 220 230 240 250
FYQRCAETVH GLAHFPHTLP GPTGLVEVAG TCLSHAQISL GSSGTPRMHC
260 270 280 290 300
SPDGEWLVPV GQCQCEPGYE ESGGSVGCTA CPTGFYRMDM NTLHCLKCPQ
310 320 330 340 350
HSVAESEGST ICTCENGHYR APGEGPQVAC TRPPSAPQNL SFSASGTQLS
360 370 380 390 400
LRWEPPRDTG GRQDIRYSVE CLQCRGIAQD GGPCQPCGKG VHFSPAASGL
410 420 430 440 450
TASTVQVEGL EPYANYTFTI KSQNRVSGLD SSSPSSASLS INMGQAESLS
460 470 480 490 500
GLSLKLVKKE PRQLELTWAG SRLQNPGGNL SYELHVLNQD EEWHQMVLEP
510 520 530 540 550
RVLLTKLQPD TTYIVRVRTL TPLGPGPFSP DHEFRTSPPV SRSLTGGEIV
560 570 580 590 600
AIIFGLLLGI ALLIGIYVFR SRRGQRQRQQ RQRERTTNVD REDKLWLKPY
610 620 630 640 650
VDLQAYEDPA QGALDFAQEL DPAWLIVDTV IGEGEFGEVY RGALRIPSQD
660 670 680 690 700
CKTVAIKTLK DTSPDGYWWN FLREATIMGQ FNHPHILRLE GVITKRKPIM
710 720 730 740 750
IITEFMENGA LDAFLKERED QLVPGQLVAM LLGIASGMNY LSGHNYVHRD
760 770 780 790 800
LAARNILVNQ NLCCKVSDFG LTRLLDDFDG TYETQGGKIP IRWTAPEAIA
810 820 830 840 850
HRIFTTASDV WSFGIVMWEV LSFGDKPYGE MSNQEVMKSI EDGYRLPPPV
860 870 880 890 900
DCPAPLYELM KNCWAYDRAR RPHFLQLQAH LEQLLTDPHS LRTIANFDPR
910 920 930 940 950
VTLRLPSLSG SDGIPYRSVS EWLESIRMKR YILHFRSAGL DTMECVLELT
960 970
AEDLTQMGIT LPGHQKRILC SIQGFKD
Length:977
Mass (Da):108,554
Last modified:April 20, 2010 - v1
Checksum:i9EC67A972BECA052
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121165 Genomic DNA. No translation available.
CH473959 Genomic DNA. Translation: EDM15513.1.
RefSeqiNP_001101328.1. NM_001107858.1.
UniGeneiRn.218221.

Genome annotation databases

EnsembliENSRNOT00000024037; ENSRNOP00000024037; ENSRNOG00000017525.
GeneIDi312279.
KEGGirno:312279.
UCSCiRGD:1304680. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121165 Genomic DNA. No translation available.
CH473959 Genomic DNA. Translation: EDM15513.1.
RefSeqiNP_001101328.1. NM_001107858.1.
UniGeneiRn.218221.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024037.

PTM databases

PhosphoSiteiD3ZDH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024037; ENSRNOP00000024037; ENSRNOG00000017525.
GeneIDi312279.
KEGGirno:312279.
UCSCiRGD:1304680. rat.

Organism-specific databases

CTDi2041.
RGDi1304680. Epha1.

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
KOiK05102.
OMAiQAYEDPA.
OrthoDBiEOG091G00W0.
TreeFamiTF315363.

Enzyme and pathway databases

ReactomeiR-RNO-2682334. EPH-Ephrin signaling.
R-RNO-3928663. EPHA-mediated growth cone collapse.
R-RNO-3928665. EPH-ephrin mediated repulsion of cells.

Gene expression databases

BgeeiENSRNOG00000017525.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZDH4_RAT
AccessioniPrimary (citable) accession number: D3ZDH4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.