Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Eph receptor A1

Gene

Epha1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei657ATPUniRule annotation1
Active sitei750Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi631 – 639ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2682334 EPH-Ephrin signaling
R-RNO-3928663 EPHA-mediated growth cone collapse
R-RNO-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Submitted name:
Eph receptor A1Imported
Submitted name:
Eph receptor A1 (Predicted)Imported
Gene namesi
Name:Epha1Imported
Synonyms:Epha1_predictedImported
ORF Names:rCG_28177Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1304680 Epha1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501408760127 – 977Sequence analysisAdd BLAST951

Proteomic databases

PeptideAtlasiD3ZDH4

Expressioni

Gene expression databases

BgeeiENSRNOG00000017525

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024037

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 210Eph LBDInterPro annotationAdd BLAST183
Domaini333 – 446Fibronectin type-IIIInterPro annotationAdd BLAST114
Domaini448 – 539Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini625 – 885Protein kinaseInterPro annotationAdd BLAST261
Domaini914 – 977SAMInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00910000144084
KOiK05102
OMAiQAYEDPA
OrthoDBiEOG091G00W0
TreeFamiTF315363

Family and domain databases

CDDicd10479 EphR_LBD_A1, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034251 EphA1_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZDH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRWPLGLA LLLLLLCAPL PPGARAEEVT LMDTSTAQGE LGWLLDPPET
60 70 80 90 100
GWSEVQQMLN GTPLYMYQDC PIQEGGDTDH WLRSNWIYRG EEASRVHVEL
110 120 130 140 150
QFTVRDCKSF PGGAGPLGCK ETFNLFYMES DQDVGIQLRR PLFQKVTTVA
160 170 180 190 200
ADQSFTIRDL ASGSVKLNVE HCSLGHLTRR GLYLAFHNPG SCVALVSVRV
210 220 230 240 250
FYQRCAETVH GLAHFPHTLP GPTGLVEVAG TCLSHAQISL GSSGTPRMHC
260 270 280 290 300
SPDGEWLVPV GQCQCEPGYE ESGGSVGCTA CPTGFYRMDM NTLHCLKCPQ
310 320 330 340 350
HSVAESEGST ICTCENGHYR APGEGPQVAC TRPPSAPQNL SFSASGTQLS
360 370 380 390 400
LRWEPPRDTG GRQDIRYSVE CLQCRGIAQD GGPCQPCGKG VHFSPAASGL
410 420 430 440 450
TASTVQVEGL EPYANYTFTI KSQNRVSGLD SSSPSSASLS INMGQAESLS
460 470 480 490 500
GLSLKLVKKE PRQLELTWAG SRLQNPGGNL SYELHVLNQD EEWHQMVLEP
510 520 530 540 550
RVLLTKLQPD TTYIVRVRTL TPLGPGPFSP DHEFRTSPPV SRSLTGGEIV
560 570 580 590 600
AIIFGLLLGI ALLIGIYVFR SRRGQRQRQQ RQRERTTNVD REDKLWLKPY
610 620 630 640 650
VDLQAYEDPA QGALDFAQEL DPAWLIVDTV IGEGEFGEVY RGALRIPSQD
660 670 680 690 700
CKTVAIKTLK DTSPDGYWWN FLREATIMGQ FNHPHILRLE GVITKRKPIM
710 720 730 740 750
IITEFMENGA LDAFLKERED QLVPGQLVAM LLGIASGMNY LSGHNYVHRD
760 770 780 790 800
LAARNILVNQ NLCCKVSDFG LTRLLDDFDG TYETQGGKIP IRWTAPEAIA
810 820 830 840 850
HRIFTTASDV WSFGIVMWEV LSFGDKPYGE MSNQEVMKSI EDGYRLPPPV
860 870 880 890 900
DCPAPLYELM KNCWAYDRAR RPHFLQLQAH LEQLLTDPHS LRTIANFDPR
910 920 930 940 950
VTLRLPSLSG SDGIPYRSVS EWLESIRMKR YILHFRSAGL DTMECVLELT
960 970
AEDLTQMGIT LPGHQKRILC SIQGFKD
Length:977
Mass (Da):108,554
Last modified:April 20, 2010 - v1
Checksum:i9EC67A972BECA052
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121165 Genomic DNA No translation available.
CH473959 Genomic DNA Translation: EDM15513.1
RefSeqiNP_001101328.1, NM_001107858.1
UniGeneiRn.218221

Genome annotation databases

EnsembliENSRNOT00000024037; ENSRNOP00000024037; ENSRNOG00000017525
GeneIDi312279
KEGGirno:312279
UCSCiRGD:1304680 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZDH4_RAT
AccessioniPrimary (citable) accession number: D3ZDH4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health