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Protein

E3 ubiquitin-protein ligase

Gene

Smurf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotationSAAS annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei696Glycyl thioester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processUbl conjugation pathwayUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-201451 Signaling by BMP
R-RNO-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-RNO-4608870 Asymmetric localization of PCP proteins
R-RNO-5632684 Hedgehog 'on' state
R-RNO-8941858 Regulation of RUNX3 expression and activity
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligaseUniRule annotation (EC:2.3.2.26UniRule annotation)
Gene namesi
Name:Smurf1Imported
ORF Names:rCG_42768Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1594738 Smurf1

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSRNOG00000000999
ExpressionAtlasiD3ZCF5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031927

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 99C2InterPro annotationAdd BLAST86
Domaini234 – 267WWInterPro annotationAdd BLAST34
Domaini280 – 313WWInterPro annotationAdd BLAST34
Domaini394 – 728HECTInterPro annotationAdd BLAST335

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00760000118966
KOiK04678
TreeFamiTF323658

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd00201 WW, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR024928 E3_ub_ligase_SMURF1
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00632 HECT, 1 hit
PF00397 WW, 2 hits
PIRSFiPIRSF001569 E3_ub_ligase_SMURF1, 2 hits
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00119 HECTc, 1 hit
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50237 HECT, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

D3ZCF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS
60 70 80 90 100
TDTVKNTLDP KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL
110 120 130 140 150
LSNAISRLKD TGYQRLDLCK LNPSDTDAVR GQIVVSLQTR DRIGGGGSVV
160 170 180 190 200
DCRGLLENEG TVYEDSGPGR PLSCLMEEPA PYTDGTGAAA GGGNCRFVES
210 220 230 240 250
PSQDQRLLVQ RLRNPEVRGS LQTPQNRPHG HQSPELPEGY EQRTTVQGQV
260 270 280 290 300
YFLHTQTGVS TWHDPRIPRD LNSVNCDELG PLPPGWEVRS TVSGRIYFVD
310 320 330 340 350
HNNRTTQFTD PRLHHIMNHQ CQLKEPSQPL QLPSEGSVED EELPAQRYER
360 370 380 390 400
DLVQKLKVLR HELSLQQPQA GHCRIEVSRE EIFEESYRQI MKMRPKDLKK
410 420 430 440 450
RLMVKFRGEE GLDYGGVARE WLYLLCHEML NPYYGLFQYS TDNIYTLQIN
460 470 480 490 500
PDSSINPDHL SYFHFVGRIM GLAVFHGHYI NGGFTVPFYK QLLGKPIQLS
510 520 530 540 550
DLESVDPELH KSLVWILEND ITPVLDHTFC VEHNAFGRIL QHELKPNGRN
560 570 580 590 600
VPVTEENKKE YVRLYVNWRF MRGIEAQFLA LQKGFNELIP QHLLKPFDQK
610 620 630 640 650
ELELIIGGLD KIDLNDWKSN TRLKHCVADS NIVRWFWQAV ETFDEERRAR
660 670 680 690 700
LLQFVTGSTR VPLQGFKALQ GAAGPRLFTI HLIDANTDNL PKAHTCFNRI
710 720
DIPPYESYEK LYEKLLTAVE ETCGFAVE
Length:728
Mass (Da):83,100
Last modified:April 3, 2013 - v2
Checksum:i2B81502C18CE107F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07035369 Genomic DNA No translation available.
AABR07035370 Genomic DNA No translation available.
CH474012 Genomic DNA Translation: EDL89624.1
RefSeqiNP_001103068.1, NM_001109598.1
UniGeneiRn.13503

Genome annotation databases

EnsembliENSRNOT00000031901; ENSRNOP00000031927; ENSRNOG00000000999
ENSRNOT00000082989; ENSRNOP00000071653; ENSRNOG00000000999
GeneIDi690516
KEGGirno:690516

Similar proteinsi

Entry informationi

Entry nameiD3ZCF5_RAT
AccessioniPrimary (citable) accession number: D3ZCF5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: May 23, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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