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D3ZCF5

- D3ZCF5_RAT

UniProt

D3ZCF5 - D3ZCF5_RAT

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Protein
E3 ubiquitin-protein ligase
Gene
Smurf1, rCG_42768
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei696 – 6961Glycyl thioester intermediate By similarityUniRule annotation

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. protein binding Source: RGD
  3. ubiquitin-protein transferase activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. negative regulation of ossification Source: Ensembl
  3. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  4. proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
  5. protein export from nucleus Source: Ensembl
  6. protein localization to cell surface Source: Ensembl
  7. protein polyubiquitination Source: Ensembl
  8. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: RefGenome
  9. receptor catabolic process Source: Ensembl
  10. regulation of axon extension Source: RGD
  11. transforming growth factor beta receptor signaling pathway Source: RefGenome
  12. ubiquitin-dependent SMAD protein catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotations

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotationSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_194641. Downregulation of TGF-beta receptor signaling.
REACT_198391. Asymmetric localization of PCP proteins.
REACT_198828. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligaseUniRule annotation (EC:6.3.2.-UniRule annotation)
Gene namesi
Name:Smurf1Imported
ORF Names:rCG_42768Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 12

Organism-specific databases

RGDi1594738. Smurf1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: RGD
  2. cytoplasm Source: RefGenome
  3. neuronal cell body Source: RGD
  4. nucleus Source: RefGenome
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains HECT (E6AP-type E3 ubiquitin-protein ligase) domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117667.
KOiK04678.
OMAiHVQTPQN.
OrthoDBiEOG77Q4W4.
TreeFamiTF323658.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR024928. E3_ub_ligase_SMURF1.
IPR000569. HECT.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 2 hits.
[Graphical view]
PIRSFiPIRSF001569. E3_ub_ligase_SMURF1. 1 hit.
SMARTiSM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZCF5-1 [UniParc]FASTAAdd to Basket

« Hide

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS    50
TDTVKNTLDP KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL 100
LSNAISRLKD TGYQRLDLCK LNPSDTDAVR GQIVVSLQTR DRIGGGGSVV 150
DCRGLLENEG TVYEDSGPGR PLSCLMEEPA PYTDGTGAAA GGGNCRFVES 200
PSQDQRLLVQ RLRNPEVRGS LQTPQNRPHG HQSPELPEGY EQRTTVQGQV 250
YFLHTQTGVS TWHDPRIPRD LNSVNCDELG PLPPGWEVRS TVSGRIYFVD 300
HNNRTTQFTD PRLHHIMNHQ CQLKEPSQPL QLPSEGSVED EELPAQRYER 350
DLVQKLKVLR HELSLQQPQA GHCRIEVSRE EIFEESYRQI MKMRPKDLKK 400
RLMVKFRGEE GLDYGGVARE WLYLLCHEML NPYYGLFQYS TDNIYTLQIN 450
PDSSINPDHL SYFHFVGRIM GLAVFHGHYI NGGFTVPFYK QLLGKPIQLS 500
DLESVDPELH KSLVWILEND ITPVLDHTFC VEHNAFGRIL QHELKPNGRN 550
VPVTEENKKE YVRLYVNWRF MRGIEAQFLA LQKGFNELIP QHLLKPFDQK 600
ELELIIGGLD KIDLNDWKSN TRLKHCVADS NIVRWFWQAV ETFDEERRAR 650
LLQFVTGSTR VPLQGFKALQ GAAGPRLFTI HLIDANTDNL PKAHTCFNRI 700
DIPPYESYEK LYEKLLTAVE ETCGFAVE 728
Length:728
Mass (Da):83,100
Last modified:April 3, 2013 - v2
Checksum:i2B81502C18CE107F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06070429 Genomic DNA. No translation available.
AABR06070430 Genomic DNA. No translation available.
CH474012 Genomic DNA. Translation: EDL89624.1.
RefSeqiNP_001103068.1. NM_001109598.1.
UniGeneiRn.13503.

Genome annotation databases

EnsembliENSRNOT00000031901; ENSRNOP00000031927; ENSRNOG00000000999.
GeneIDi690516.
KEGGirno:690516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06070429 Genomic DNA. No translation available.
AABR06070430 Genomic DNA. No translation available.
CH474012 Genomic DNA. Translation: EDL89624.1 .
RefSeqi NP_001103068.1. NM_001109598.1.
UniGenei Rn.13503.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000031901 ; ENSRNOP00000031927 ; ENSRNOG00000000999 .
GeneIDi 690516.
KEGGi rno:690516.

Organism-specific databases

CTDi 57154.
RGDi 1594738. Smurf1.

Phylogenomic databases

GeneTreei ENSGT00750000117667.
KOi K04678.
OMAi HVQTPQN.
OrthoDBi EOG77Q4W4.
TreeFami TF323658.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_194641. Downregulation of TGF-beta receptor signaling.
REACT_198391. Asymmetric localization of PCP proteins.
REACT_198828. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

Miscellaneous databases

NextBioi 35566446.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR024928. E3_ub_ligase_SMURF1.
IPR000569. HECT.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 2 hits.
[Graphical view ]
PIRSFi PIRSF001569. E3_ub_ligase_SMURF1. 1 hit.
SMARTi SM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
SSF56204. SSF56204. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZCF5_RAT
AccessioniPrimary (citable) accession number: D3ZCF5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: September 3, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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