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D3ZBQ1

- D3ZBQ1_RAT

UniProt

D3ZBQ1 - D3ZBQ1_RAT

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Protein
Submitted name:

Forkhead box O3a (Predicted)

Gene
Foxo3, Foxo3a_predicted, rCG_58542
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. protein kinase binding Source: RefGenome
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl
  5. transcription cofactor binding Source: RGD

GO - Biological processi

  1. antral ovarian follicle growth Source: Ensembl
  2. cellular response to DNA damage stimulus Source: RefGenome
  3. DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  4. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  5. glucose homeostasis Source: Ensembl
  6. initiation of primordial ovarian follicle growth Source: Ensembl
  7. insulin receptor signaling pathway Source: RefGenome
  8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. oocyte maturation Source: Ensembl
  10. organ development Source: RefGenome
  11. ovulation from ovarian follicle Source: Ensembl
  12. pattern specification process Source: RefGenome
  13. positive regulation of erythrocyte differentiation Source: Ensembl
  14. positive regulation of neuron apoptotic process Source: Ensembl
  15. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  16. regulation of cell proliferation Source: RefGenome
  17. regulation of translation Source: Ensembl
  18. tissue development Source: RefGenome
  19. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_194664. Signaling by NODAL.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.

Names & Taxonomyi

Protein namesi
Submitted name:
Forkhead box O3a (Predicted)Imported
Submitted name:
Protein Foxo3Imported
Gene namesi
Name:Foxo3Imported
Synonyms:Foxo3a_predictedImported
ORF Names:rCG_58542Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi1309196. Foxo3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. membrane Source: Ensembl
  3. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Interactioni

Protein-protein interaction databases

MINTiMINT-8375868.

Family & Domainsi

Sequence similaritiesi

Contains fork-head DNA-binding domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00390000000589.
KOiK09408.
OMAiNLPVMGH.
OrthoDBiEOG7R2BJD.
TreeFamiTF315583.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZBQ1-1 [UniParc]FASTAAdd to Basket

« Hide

MAEAPASPVP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE    50
TAADSMIPEE DDDEDDEDSG GRGSSAMVIG GGVSSALGSG LLLEDSARLL 100
SPGGQDLGTG PASSAGALSG GTQTQLQPQQ PLPPPQPGAA GGSGQPRKCS 150
SRRNAWGNLS YADLITRAIE SSPDKRLTLS QIYEWMVRCV PYFKDKGDSN 200
SSAGWKNSIR HNLSLHSRFM RVQNEGTGKS SWWIINPDGG KSGKAPRRRA 250
VSMDNSNKYT KSRGRAAKKK AALQAAPESA DDSPSQLSKW PGSPTSRSSD 300
ELDAWTDFRS RTNSNASTVS GRLSPILAST ELDDVQDDDG PLSPMLYSSS 350
ASLSPSVSKP CTVELPRLTD MAGTMNLNDG LAENLMDDLL DNIALPPSQA 400
SPPGGLMQRS SSFPYTAKSS GLGSPTSSFN STVFGPASLN SLRQSPMQTI 450
QENRPATFSS VSHYGNQTLQ DLLTSDSLSH SDVMMTQSDP LMSQASTAVS 500
AQNARRNVML RNDPMMSFAA QPTQGSLVNQ NLLHHQHQTQ GALGGSRALS 550
NSVSNMGLSD SSSLGSAKHQ QQSPVSQSMQ TLSDSLSGSS LYSASANLPV 600
MGHDKFPSDL DLDMFNGSLE CDMESIIRSE LMDADGLDFN FDSLISTQNV 650
VGLNVGNFTG AKQASSQSWV PG 672
Length:672
Mass (Da):71,198
Last modified:April 20, 2010 - v1
Checksum:i488905ADCB3A7A2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06101726 Genomic DNA. No translation available.
AABR06101727 Genomic DNA. No translation available.
AABR06101728 Genomic DNA. No translation available.
AABR06101729 Genomic DNA. No translation available.
AABR06101730 Genomic DNA. No translation available.
CH474025 Genomic DNA. Translation: EDL99711.1.
RefSeqiNP_001099865.1. NM_001106395.1.
XP_006256620.1. XM_006256558.1.
XP_006256621.1. XM_006256559.1.
UniGeneiRn.165338.
Rn.24593.

Genome annotation databases

EnsembliENSRNOT00000000327; ENSRNOP00000000327; ENSRNOG00000000299.
GeneIDi294515.
KEGGirno:294515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06101726 Genomic DNA. No translation available.
AABR06101727 Genomic DNA. No translation available.
AABR06101728 Genomic DNA. No translation available.
AABR06101729 Genomic DNA. No translation available.
AABR06101730 Genomic DNA. No translation available.
CH474025 Genomic DNA. Translation: EDL99711.1 .
RefSeqi NP_001099865.1. NM_001106395.1.
XP_006256620.1. XM_006256558.1.
XP_006256621.1. XM_006256559.1.
UniGenei Rn.165338.
Rn.24593.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8375868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000327 ; ENSRNOP00000000327 ; ENSRNOG00000000299 .
GeneIDi 294515.
KEGGi rno:294515.

Organism-specific databases

CTDi 2309.
RGDi 1309196. Foxo3.

Phylogenomic databases

GeneTreei ENSGT00390000000589.
KOi K09408.
OMAi NLPVMGH.
OrthoDBi EOG7R2BJD.
TreeFami TF315583.

Enzyme and pathway databases

Reactomei REACT_194664. Signaling by NODAL.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.

Miscellaneous databases

NextBioi 638243.
PROi D3ZBQ1.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZBQ1_RAT
AccessioniPrimary (citable) accession number: D3ZBQ1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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