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D3ZBQ1

- D3ZBQ1_RAT

UniProt

D3ZBQ1 - D3ZBQ1_RAT

Protein
Submitted name:

Forkhead box O3a (Predicted)

Gene

Foxo3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. transcription cofactor binding Source: RGD

    GO - Biological processi

    1. antral ovarian follicle growth Source: Ensembl
    2. DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    3. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    4. glucose homeostasis Source: Ensembl
    5. initiation of primordial ovarian follicle growth Source: Ensembl
    6. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    7. oocyte maturation Source: Ensembl
    8. ovulation from ovarian follicle Source: Ensembl
    9. positive regulation of erythrocyte differentiation Source: Ensembl
    10. positive regulation of neuron apoptotic process Source: Ensembl
    11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. regulation of translation Source: Ensembl
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_194664. Signaling by NODAL.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Forkhead box O3a (Predicted)Imported
    Submitted name:
    Protein Foxo3Imported
    Gene namesi
    Name:Foxo3Imported
    Synonyms:Foxo3a_predictedImported
    ORF Names:rCG_58542Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi1309196. Foxo3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. membrane Source: Ensembl
    3. nucleus Source: RGD

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8375868.

    Family & Domainsi

    Sequence similaritiesi

    Contains fork-head DNA-binding domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000000589.
    KOiK09408.
    OMAiNLPVMGH.
    OrthoDBiEOG7R2BJD.
    TreeFamiTF315583.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3ZBQ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEAPASPVP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE    50
    TAADSMIPEE DDDEDDEDSG GRGSSAMVIG GGVSSALGSG LLLEDSARLL 100
    SPGGQDLGTG PASSAGALSG GTQTQLQPQQ PLPPPQPGAA GGSGQPRKCS 150
    SRRNAWGNLS YADLITRAIE SSPDKRLTLS QIYEWMVRCV PYFKDKGDSN 200
    SSAGWKNSIR HNLSLHSRFM RVQNEGTGKS SWWIINPDGG KSGKAPRRRA 250
    VSMDNSNKYT KSRGRAAKKK AALQAAPESA DDSPSQLSKW PGSPTSRSSD 300
    ELDAWTDFRS RTNSNASTVS GRLSPILAST ELDDVQDDDG PLSPMLYSSS 350
    ASLSPSVSKP CTVELPRLTD MAGTMNLNDG LAENLMDDLL DNIALPPSQA 400
    SPPGGLMQRS SSFPYTAKSS GLGSPTSSFN STVFGPASLN SLRQSPMQTI 450
    QENRPATFSS VSHYGNQTLQ DLLTSDSLSH SDVMMTQSDP LMSQASTAVS 500
    AQNARRNVML RNDPMMSFAA QPTQGSLVNQ NLLHHQHQTQ GALGGSRALS 550
    NSVSNMGLSD SSSLGSAKHQ QQSPVSQSMQ TLSDSLSGSS LYSASANLPV 600
    MGHDKFPSDL DLDMFNGSLE CDMESIIRSE LMDADGLDFN FDSLISTQNV 650
    VGLNVGNFTG AKQASSQSWV PG 672
    Length:672
    Mass (Da):71,198
    Last modified:April 20, 2010 - v1
    Checksum:i488905ADCB3A7A2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06101726 Genomic DNA. No translation available.
    AABR06101727 Genomic DNA. No translation available.
    AABR06101728 Genomic DNA. No translation available.
    AABR06101729 Genomic DNA. No translation available.
    AABR06101730 Genomic DNA. No translation available.
    CH474025 Genomic DNA. Translation: EDL99711.1.
    RefSeqiNP_001099865.1. NM_001106395.1.
    XP_006256620.1. XM_006256558.1.
    XP_006256621.1. XM_006256559.1.
    UniGeneiRn.165338.
    Rn.24593.

    Genome annotation databases

    EnsembliENSRNOT00000000327; ENSRNOP00000000327; ENSRNOG00000000299.
    GeneIDi294515.
    KEGGirno:294515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06101726 Genomic DNA. No translation available.
    AABR06101727 Genomic DNA. No translation available.
    AABR06101728 Genomic DNA. No translation available.
    AABR06101729 Genomic DNA. No translation available.
    AABR06101730 Genomic DNA. No translation available.
    CH474025 Genomic DNA. Translation: EDL99711.1 .
    RefSeqi NP_001099865.1. NM_001106395.1.
    XP_006256620.1. XM_006256558.1.
    XP_006256621.1. XM_006256559.1.
    UniGenei Rn.165338.
    Rn.24593.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8375868.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000000327 ; ENSRNOP00000000327 ; ENSRNOG00000000299 .
    GeneIDi 294515.
    KEGGi rno:294515.

    Organism-specific databases

    CTDi 2309.
    RGDi 1309196. Foxo3.

    Phylogenomic databases

    GeneTreei ENSGT00390000000589.
    KOi K09408.
    OMAi NLPVMGH.
    OrthoDBi EOG7R2BJD.
    TreeFami TF315583.

    Enzyme and pathway databases

    Reactomei REACT_194664. Signaling by NODAL.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.

    Miscellaneous databases

    NextBioi 638243.
    PROi D3ZBQ1.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD3ZBQ1_RAT
    AccessioniPrimary (citable) accession number: D3ZBQ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3