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Protein
Submitted name:

Forkhead box O3

Gene

Foxo3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi156 – 250Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscriptionSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-1181150. Signaling by NODAL.
R-RNO-198693. AKT phosphorylates targets in the nucleus.
R-RNO-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Forkhead box O3Imported
Submitted name:
Forkhead box O3a (Predicted)Imported
Gene namesi
Name:Foxo3Imported
Synonyms:Foxo3a_predictedImported
ORF Names:rCG_58542Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1309196. Foxo3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000000299.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-8375868.
STRINGi10116.ENSRNOP00000000327.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 250Fork-headInterPro annotationAdd BLAST95

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00790000123003.
KOiK09408.
OMAiPSVSKPC.
OrthoDBiEOG091G06K3.
TreeFamiTF315583.

Family and domain databases

CDDicd00059. FH. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR032067. FOXO-TAD.
IPR032068. FOXO_KIX-bd.
IPR030456. TF_fork_head_CS_2.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PF16676. FOXO-TAD. 1 hit.
PF16675. FOXO_KIX_bdg. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZBQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAPASPVP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE
60 70 80 90 100
TAADSMIPEE DDDEDDEDSG GRGSSAMVIG GGVSSALGSG LLLEDSARLL
110 120 130 140 150
SPGGQDLGTG PASSAGALSG GTQTQLQPQQ PLPPPQPGAA GGSGQPRKCS
160 170 180 190 200
SRRNAWGNLS YADLITRAIE SSPDKRLTLS QIYEWMVRCV PYFKDKGDSN
210 220 230 240 250
SSAGWKNSIR HNLSLHSRFM RVQNEGTGKS SWWIINPDGG KSGKAPRRRA
260 270 280 290 300
VSMDNSNKYT KSRGRAAKKK AALQAAPESA DDSPSQLSKW PGSPTSRSSD
310 320 330 340 350
ELDAWTDFRS RTNSNASTVS GRLSPILAST ELDDVQDDDG PLSPMLYSSS
360 370 380 390 400
ASLSPSVSKP CTVELPRLTD MAGTMNLNDG LAENLMDDLL DNIALPPSQA
410 420 430 440 450
SPPGGLMQRS SSFPYTAKSS GLGSPTSSFN STVFGPASLN SLRQSPMQTI
460 470 480 490 500
QENRPATFSS VSHYGNQTLQ DLLTSDSLSH SDVMMTQSDP LMSQASTAVS
510 520 530 540 550
AQNARRNVML RNDPMMSFAA QPTQGSLVNQ NLLHHQHQTQ GALGGSRALS
560 570 580 590 600
NSVSNMGLSD SSSLGSAKHQ QQSPVSQSMQ TLSDSLSGSS LYSASANLPV
610 620 630 640 650
MGHDKFPSDL DLDMFNGSLE CDMESIIRSE LMDADGLDFN FDSLISTQNV
660 670
VGLNVGNFTG AKQASSQSWV PG
Length:672
Mass (Da):71,198
Last modified:April 20, 2010 - v1
Checksum:i488905ADCB3A7A2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07045405 Genomic DNA. No translation available.
CH474025 Genomic DNA. Translation: EDL99711.1.
RefSeqiNP_001099865.1. NM_001106395.1.
UniGeneiRn.165338.
Rn.24593.

Genome annotation databases

EnsembliENSRNOT00000000327; ENSRNOP00000000327; ENSRNOG00000000299.
GeneIDi294515.
KEGGirno:294515.

Similar proteinsi

Entry informationi

Entry nameiD3ZBQ1_RAT
AccessioniPrimary (citable) accession number: D3ZBQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 22, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported