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Protein
Submitted name:

Eph receptor A2

Gene

Epha2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei647ATPUniRule annotation1
Active sitei740Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi620 – 628ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2682334. EPH-Ephrin signaling.
R-RNO-3928663. EPHA-mediated growth cone collapse.
R-RNO-3928665. EPH-ephrin mediated repulsion of cells.

Names & Taxonomyi

Protein namesi
Submitted name:
Eph receptor A2Imported
Submitted name:
Eph receptor A2 (Predicted)Imported
Gene namesi
Name:Epha2Imported
Synonyms:Epha2_predictedImported
ORF Names:rCG_31362Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1307204. Epha2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei536 – 559HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500968868720 – 977Sequence analysisAdd BLAST958

Expressioni

Gene expression databases

BgeeiENSRNOG00000009222.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012328.

Structurei

3D structure databases

SMRiD3ZBN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 205Eph LBD (Eph ligand-binding)InterPro annotationAdd BLAST179
Domaini329 – 433Fibronectin type-IIIInterPro annotationAdd BLAST105
Domaini439 – 530Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini614 – 876Protein kinaseInterPro annotationAdd BLAST263
Domaini905 – 969SAM (sterile alpha motif)InterPro annotationAdd BLAST65

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
InParanoidiD3ZBN3.
KOiK05103.
OMAiCSPGFFK.
OrthoDBiEOG091G00W0.

Family and domain databases

CDDicd10480. EphR_LBD_A2. 1 hit.
cd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR027936. Eph_TM.
IPR034263. EphA2_rcpt_lig-bd.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
PfamiView protein in Pfam
PF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZBN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRAAGFCL ALLWGCALAA AAAQGKEVVL LDFAAMKGEL GWLTHPYGKG
60 70 80 90 100
WDLMQNIMND MPIYMYSVCN VVSGDQDNWL RTNWVYREEA ERIFIELKFT
110 120 130 140 150
VRDCNSFPGG ASSCKETFNL YYAESDVDYG TNFQKRQFTK IDTIAPDEIT
160 170 180 190 200
VSSDFEARNV KLNVEERMVG PLTRKGFYLA FQDIGACVAL LSVRVYYKKC
210 220 230 240 250
PEMLQSLARF PETIAVAVSD AQPLATVAGT CVDHAVVPYG GEGPLMHCTV
260 270 280 290 300
DGEWLVPIGQ CLCQEGYEKV EDACQACSPG FFKSEASESP CLQCPEHTLP
310 320 330 340 350
STEGATSCQC EEGYFRAPED PLSMPCTRPP SAPHYLTAIG MGAKVELRWT
360 370 380 390 400
APQDTGGRKD IVYSVTCEQC WPESGECGSC EASVQYSEPP QALTRTSVTV
410 420 430 440 450
SDLEPHMNYT FTVEARNGVS DLVNSRSFRT ASVSINQTEP PKVRLEDRST
460 470 480 490 500
TSLSVAWSIP VPQQSRVWKY EVTYRKKGDA NSYNVHRTDG FSVTLDGLAP
510 520 530 540 550
GTTYLVQVQA LTQEGQGAGS KVHEFQTLST EGSATMAVIG GVAVGVVLLL
560 570 580 590 600
VLAGIGFFIH RRRRNLRARQ SSEDVYFSKS EQLKPLKTYV DPHTYEDPNQ
610 620 630 640 650
AVLKFTTEIH PSCVSRQKVI GAGEFGEVYK GTLKSSSGKK EIPVAIKTLK
660 670 680 690 700
AGYTEKQRVD FLSEASIMGQ FSHHNIIRLE GVVSKYKPMM IITEYMENGA
710 720 730 740 750
LDKFLREKDG EFSVLQLVGM LRGIASGMKY LANMNYVHRD LAARNILVNS
760 770 780 790 800
NLVCKVSDFG LSRVLEDDPE ATYTTSGGKI PIRWTAPEAI SYRKFTSASD
810 820 830 840 850
VWSYGIVMWE VMTYGERPYW ELSNHEVMKA INDGFRLPTP MDCPSAIYQL
860 870 880 890 900
MMQCWQQERS RRPKFADIVS ILDKLIRAPD SLKTLADFDP RVSIRLPSTS
910 920 930 940 950
GSEGVPFRTV SEWLESIKMQ QYTEHFMVAG YTAIEKVVQM SNDDIKRIGV
960 970
RLPGHQKRIA YSLLGLKDQV NTVGIPI
Length:977
Mass (Da):108,741
Last modified:July 22, 2015 - v3
Checksum:i480C4F6DF2FA7373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120594 Genomic DNA. No translation available.
CH473968 Genomic DNA. Translation: EDL80978.1.
RefSeqiNP_001102447.1. NM_001108977.1.
UniGeneiRn.23415.

Genome annotation databases

EnsembliENSRNOT00000012328; ENSRNOP00000012328; ENSRNOG00000009222.
GeneIDi366492.
KEGGirno:366492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120594 Genomic DNA. No translation available.
CH473968 Genomic DNA. Translation: EDL80978.1.
RefSeqiNP_001102447.1. NM_001108977.1.
UniGeneiRn.23415.

3D structure databases

SMRiD3ZBN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012328; ENSRNOP00000012328; ENSRNOG00000009222.
GeneIDi366492.
KEGGirno:366492.

Organism-specific databases

CTDi1969.
RGDi1307204. Epha2.

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
InParanoidiD3ZBN3.
KOiK05103.
OMAiCSPGFFK.
OrthoDBiEOG091G00W0.

Enzyme and pathway databases

ReactomeiR-RNO-2682334. EPH-Ephrin signaling.
R-RNO-3928663. EPHA-mediated growth cone collapse.
R-RNO-3928665. EPH-ephrin mediated repulsion of cells.

Gene expression databases

BgeeiENSRNOG00000009222.

Family and domain databases

CDDicd10480. EphR_LBD_A2. 1 hit.
cd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR027936. Eph_TM.
IPR034263. EphA2_rcpt_lig-bd.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
PfamiView protein in Pfam
PF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZBN3_RAT
AccessioniPrimary (citable) accession number: D3ZBN3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: April 12, 2017
This is version 70 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.