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Protein

E3 ubiquitin-protein ligase RNF182

Gene

Rnf182

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 68RING-typePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF182 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 182
RING-type E3 ubiquitin transferase RNF182Curated
Gene namesi
Name:Rnf182
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1560399. Rnf182.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003956711 – 247E3 ubiquitin-protein ligase RNF182Add BLAST247

Proteomic databases

PaxDbiD3ZBM4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018070.
GenevisibleiD3ZBM4. RN.

Interactioni

Subunit structurei

Interacts with ATP6V0C.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024323.

Structurei

3D structure databases

SMRiD3ZBM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The RING-type zinc finger domain is required for E3 ligase activity.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 68RING-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF6. Eukaryota.
ENOG410XT90. LUCA.
GeneTreeiENSGT00730000111020.
InParanoidiD3ZBM4.
KOiK11983.
OMAiCAKCLCK.
OrthoDBiEOG091G0KUF.
PhylomeDBiD3ZBM4.
TreeFamiTF331690.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZBM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQPPEEPA EFQVSDELEC KICYNRYNLK QRKPKVLECC HRVCAKCLYK
60 70 80 90 100
IIDFGDSPQG VIVCPFCRFE TCLPDDEVSS LPDDNNILVN LTCGSKGKKC
110 120 130 140 150
LPENPTELLL TPKRLASLVS PSHTSSNCLV ITIMEVQRES SPSLSSTPVV
160 170 180 190 200
EFYRPASFDS VTTVSHNWTV WNCTSLLFQT SIRVLVWLLG LLYFSSLPLG
210 220 230 240
IYLLVSKKVT LGVVFVSLVP SSLVILMVYG FCQCVCHEFL DCMALPS
Length:247
Mass (Da):27,546
Last modified:April 20, 2010 - v1
Checksum:i43E7646C4A35BF49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473977 Genomic DNA. Translation: EDL98193.1.
RefSeqiNP_001102587.1. NM_001109117.1.
XP_017456133.1. XM_017600644.1.
UniGeneiRn.141306.

Genome annotation databases

EnsembliENSRNOT00000024323; ENSRNOP00000024323; ENSRNOG00000018070.
GeneIDi498726.
KEGGirno:498726.
UCSCiRGD:1560399. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473977 Genomic DNA. Translation: EDL98193.1.
RefSeqiNP_001102587.1. NM_001109117.1.
XP_017456133.1. XM_017600644.1.
UniGeneiRn.141306.

3D structure databases

SMRiD3ZBM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024323.

Proteomic databases

PaxDbiD3ZBM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024323; ENSRNOP00000024323; ENSRNOG00000018070.
GeneIDi498726.
KEGGirno:498726.
UCSCiRGD:1560399. rat.

Organism-specific databases

CTDi221687.
RGDi1560399. Rnf182.

Phylogenomic databases

eggNOGiENOG410ITF6. Eukaryota.
ENOG410XT90. LUCA.
GeneTreeiENSGT00730000111020.
InParanoidiD3ZBM4.
KOiK11983.
OMAiCAKCLCK.
OrthoDBiEOG091G0KUF.
PhylomeDBiD3ZBM4.
TreeFamiTF331690.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiD3ZBM4.

Gene expression databases

BgeeiENSRNOG00000018070.
GenevisibleiD3ZBM4. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRN182_RAT
AccessioniPrimary (citable) accession number: D3ZBM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 20, 2010
Last modified: March 15, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.