ID   A6I0Z0_RAT              Unreviewed;       270 AA.
AC   A6I0Z0; D3Z9J1;
DT   28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 1.
DT   27-MAR-2024, entry version 5.
DE   SubName: Full=Dickkopf WNT signaling pathway inhibitor 1 {ECO:0000313|Ensembl:ENSRNOP00000064286.1};
DE   SubName: Full=Dickkopf-like protein 1 {ECO:0000313|EMBL:AFI61655.1};
GN   Name=Dkk1 {ECO:0000313|Ensembl:ENSRNOP00000064286.1,
GN   ECO:0000313|RGD:1307313};
GN   Synonyms=DKK1 {ECO:0000313|EMBL:AFI61655.1}, LOC100912050
GN   {ECO:0000313|RGD:1307313};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AFI61655.1};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000064286.1, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000064286.1,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:AFI61655.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Hu L., Jiang G., Yang J., Liu S.;
RT   "Molecular cloning and bioinformatic analysis of DKK1.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000064286.1}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000064286.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the dickkopf family.
CC       {ECO:0000256|ARBA:ARBA00010842}.
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DR   EMBL; JN966752; AFI61655.1; -; mRNA.
DR   RefSeq; NP_001099820.1; NM_001106350.1.
DR   RefSeq; XP_017446053.1; XM_017590564.1.
DR   STRING; 10116.ENSRNOP00000015771; -.
DR   ChEMBL; CHEMBL4523111; -.
DR   PaxDb; 10116-ENSRNOP00000015771; -.
DR   Ensembl; ENSRNOT00000074393.3; ENSRNOP00000064286.1; ENSRNOG00000048688.3.
DR   GeneID; 293897; -.
DR   KEGG; rno:293897; -.
DR   UCSC; RGD:1307313; rat.
DR   AGR; RGD:1307313; -.
DR   CTD; 22943; -.
DR   RGD; 1307313; Dkk1.
DR   eggNOG; KOG1218; Eukaryota.
DR   GeneTree; ENSGT00940000161319; -.
DR   HOGENOM; CLU_080459_0_0_1; -.
DR   OMA; LDNYQPY; -.
DR   OrthoDB; 4329885at2759; -.
DR   TreeFam; TF330916; -.
DR   Reactome; R-RNO-3772470; Negative regulation of TCF-dependent signaling by WNT ligand antagonists.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000011692; Expressed in adult mammalian kidney.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0039706; F:co-receptor binding; ISO:RGD.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; ISO:RGD.
DR   GO; GO:0048019; F:receptor antagonist activity; ISO:RGD.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; ISO:RGD.
DR   GO; GO:0000902; P:cell morphogenesis; ISO:RGD.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; ISO:RGD.
DR   GO; GO:0007492; P:endoderm development; ISO:RGD.
DR   GO; GO:0001706; P:endoderm formation; ISO:RGD.
DR   GO; GO:0060325; P:face morphogenesis; ISO:RGD.
DR   GO; GO:0030900; P:forebrain development; ISO:RGD.
DR   GO; GO:0001942; P:hair follicle development; ISO:RGD.
DR   GO; GO:0060323; P:head morphogenesis; ISO:RGD.
DR   GO; GO:0003129; P:heart induction; ISO:RGD.
DR   GO; GO:0007611; P:learning or memory; ISO:RGD.
DR   GO; GO:0060173; P:limb development; ISO:RGD.
DR   GO; GO:0001707; P:mesoderm formation; ISO:RGD.
DR   GO; GO:0061743; P:motor learning; ISO:RGD.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISO:RGD.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:RGD.
DR   GO; GO:2000726; P:negative regulation of cardiac muscle cell differentiation; ISO:RGD.
DR   GO; GO:0042662; P:negative regulation of mesodermal cell fate specification; ISO:RGD.
DR   GO; GO:0010977; P:negative regulation of neuron projection development; ISO:RGD.
DR   GO; GO:0030279; P:negative regulation of ossification; IMP:RGD.
DR   GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; ISO:RGD.
DR   GO; GO:1905607; P:negative regulation of presynapse assembly; ISO:RGD.
DR   GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISO:RGD.
DR   GO; GO:1904723; P:negative regulation of Wnt-Frizzled-LRP5/6 complex assembly; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; ISO:RGD.
DR   GO; GO:1904958; P:positive regulation of midbrain dopaminergic neuron differentiation; ISO:RGD.
DR   GO; GO:0042663; P:regulation of endodermal cell fate specification; ISO:RGD.
DR   GO; GO:0002090; P:regulation of receptor internalization; ISO:RGD.
DR   GO; GO:0050807; P:regulation of synapse organization; ISO:RGD.
DR   GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISO:RGD.
DR   GO; GO:0030111; P:regulation of Wnt signaling pathway; ISO:RGD.
DR   GO; GO:0032526; P:response to retinoic acid; ISO:RGD.
DR   GO; GO:0016055; P:Wnt signaling pathway; ISO:RGD.
DR   GO; GO:0090244; P:Wnt signaling pathway involved in somitogenesis; ISO:RGD.
DR   CDD; cd23272; Dkk1_Cys2; 1.
DR   CDD; cd23026; Dkk1_N_Cys1; 1.
DR   Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR048500; DIKK1/2/4_C-subdom1.
DR   InterPro; IPR048499; DIKK1/2/4_C-subdom2.
DR   InterPro; IPR039863; DKK1-4.
DR   InterPro; IPR047304; Dkk1_Cys2.
DR   InterPro; IPR047305; Dkk1_N.
DR   PANTHER; PTHR12113:SF11; DICKKOPF-RELATED PROTEIN 1; 1.
DR   PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR   Pfam; PF04706; Dickkopf_N; 1.
DR   Pfam; PF21481; DIKK1-2-4_C-subdom1; 1.
DR   Pfam; PF21479; DIKK1-2-4_C-subdom2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..270
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5041156386"
FT   DOMAIN          86..142
FT                   /note="Dickkopf N-terminal cysteine-rich"
FT                   /evidence="ECO:0000259|Pfam:PF04706"
FT   DOMAIN          189..218
FT                   /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT                   1"
FT                   /evidence="ECO:0000259|Pfam:PF21481"
FT   DOMAIN          221..270
FT                   /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT                   2"
FT                   /evidence="ECO:0000259|Pfam:PF21479"
SQ   SEQUENCE   270 AA;  29149 MW;  DED5D89186DD993F CRC64;
     MTVVRAVAAV RFLVVLSTMA LCSLPPLGVS ATLNSVLINS NAIKNLPPPL GGAGGQPGSA
     VSVAPGVLYE GGNKYQTLDN YQPYPCAEDE ECGTDEYCSS PSRGAAGVGG VQICLACRKR
     RKRCMRHAMC CPGNYCKNGI CMPSDHSHLP RGEIEEGIIE NLGNDHGAGD GYPRRTTLTS
     KIYHTKGQEG SVCLRSSDCA TGLCCARHFW SKICKPVLKE GQVCTKHRRK GSHGLEIFQR
     CYCGEGLACR IQKDHHQTSN SSRLHTCQRH
//