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Protein
Submitted name:

Dickkopf WNT-signaling pathway inhibitor 1

Gene

Dkk1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Names & Taxonomyi

Protein namesi
Submitted name:
Dickkopf WNT-signaling pathway inhibitor 1Imported
Submitted name:
Dickkopf homolog 1 (Xenopus laevis) (Predicted)Imported
Submitted name:
Dickkopf-like protein 1Imported
Gene namesi
Name:Dkk1Imported
Synonyms:DKK1Imported, Dkk1_predictedImported, LOC100912050Imported, NEWGENE_1307313Imported
ORF Names:rCG_48380Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307313. Dkk1.
11410606. NEWGENE_1307313.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_501120493032 – 270Sequence analysisAdd BLAST239

Expressioni

Gene expression databases

BgeeiENSRNOG00000011692.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064286.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 142Dickkopf_NInterPro annotationAdd BLAST57

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IRWP. Eukaryota.
ENOG4111FNB. LUCA.
GeneTreeiENSGT00390000007000.
KOiK02165.
OMAiYHTKGQE.
OrthoDBiEOG091G0H13.
TreeFamiTF330916.

Family and domain databases

InterProiView protein in InterPro
IPR006796. Dickkopf_N.
PfamiView protein in Pfam
PF04706. Dickkopf_N. 1 hit.

Sequencei

Sequence statusi: Complete.

D3Z9J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVVRAVAAV RFLVVLSTMA LCSLPPLGVS ATLNSVLINS NAIKNLPPPL
60 70 80 90 100
GGAGGQPGSA VSVAPGVLYE GGNKYQTLDN YQPYPCAEDE ECGTDEYCSS
110 120 130 140 150
PSRGAAGVGG VQICLACRKR RKRCMRHAMC CPGNYCKNGI CMPSDHSHLP
160 170 180 190 200
RGEIEEGIIE NLGNDHGAGD GYPRRTTLTS KIYHTKGQEG SVCLRSSDCA
210 220 230 240 250
TGLCCARHFW SKICKPVLKE GQVCTKHRRK GSHGLEIFQR CYCGEGLACR
260 270
IQKDHHQTSN SSRLHTCQRH
Length:270
Mass (Da):29,149
Last modified:April 20, 2010 - v1
Checksum:iDED5D89186DD993F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006710 Genomic DNA. No translation available.
AABR07006712 Genomic DNA. No translation available.
JN966752 mRNA. Translation: AFI61655.1.
CH473953 Genomic DNA. Translation: EDM13121.1.
RefSeqiNP_001099820.1. NM_001106350.1.
XP_017446053.1. XM_017590564.1.
UniGeneiRn.214343.

Genome annotation databases

EnsembliENSRNOT00000015771; ENSRNOP00000015771; ENSRNOG00000011692.
ENSRNOT00000074393; ENSRNOP00000064286; ENSRNOG00000048688.
GeneIDi108348170.
293897.
KEGGirno:108348170.
rno:293897.
UCSCiRGD:1307313. rat.

Similar proteinsi

Entry informationi

Entry nameiD3Z9J1_RAT
AccessioniPrimary (citable) accession number: D3Z9J1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported