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Protein
Submitted name:

Dickkopf homolog 1 (Xenopus laevis) (Predicted)

Gene

Dkk1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. multicellular organismal development Source: InterPro
  2. negative regulation of ossification Source: RGD
  3. negative regulation of Wnt signaling pathway Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_205336. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_212065. TCF dependent signaling in response to WNT.
REACT_249766. misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Dickkopf homolog 1 (Xenopus laevis) (Predicted)Imported
Submitted name:
Dickkopf-like protein 1Imported
Submitted name:
Protein Dkk1Imported
Gene namesi
Name:Dkk1Imported
Synonyms:DKK1Imported, Dkk1_predictedImported
ORF Names:rCG_48380Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1307313. Dkk1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000007000.
KOiK02165.
OMAiRSSDCAT.
OrthoDBiEOG7K3TMT.
TreeFamiTF330916.

Family and domain databases

InterProiIPR006796. Dickkopf_N.
[Graphical view]
PfamiPF04706. Dickkopf_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Z9J1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVVRAVAAV RFLVVLSTMA LCSLPPLGVS ATLNSVLINS NAIKNLPPPL
60 70 80 90 100
GGAGGQPGSA VSVAPGVLYE GGNKYQTLDN YQPYPCAEDE ECGTDEYCSS
110 120 130 140 150
PSRGAAGVGG VQICLACRKR RKRCMRHAMC CPGNYCKNGI CMPSDHSHLP
160 170 180 190 200
RGEIEEGIIE NLGNDHGAGD GYPRRTTLTS KIYHTKGQEG SVCLRSSDCA
210 220 230 240 250
TGLCCARHFW SKICKPVLKE GQVCTKHRRK GSHGLEIFQR CYCGEGLACR
260 270
IQKDHHQTSN SSRLHTCQRH
Length:270
Mass (Da):29,149
Last modified:April 20, 2010 - v1
Checksum:iDED5D89186DD993F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06010531 Genomic DNA. No translation available.
AABR06010532 Genomic DNA. No translation available.
AABR06010533 Genomic DNA. No translation available.
JN966752 mRNA. Translation: AFI61655.1.
CH473953 Genomic DNA. Translation: EDM13121.1.
RefSeqiNP_001099820.1. NM_001106350.1.
XP_003749137.1. XM_003749089.3.
UniGeneiRn.214343.

Genome annotation databases

EnsembliENSRNOT00000015771; ENSRNOP00000015771; ENSRNOG00000011692.
ENSRNOT00000074393; ENSRNOP00000064286; ENSRNOG00000048688.
GeneIDi100912050.
293897.
KEGGirno:100912050.
rno:293897.
UCSCiRGD:1307313. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06010531 Genomic DNA. No translation available.
AABR06010532 Genomic DNA. No translation available.
AABR06010533 Genomic DNA. No translation available.
JN966752 mRNA. Translation: AFI61655.1.
CH473953 Genomic DNA. Translation: EDM13121.1.
RefSeqiNP_001099820.1. NM_001106350.1.
XP_003749137.1. XM_003749089.3.
UniGeneiRn.214343.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015771; ENSRNOP00000015771; ENSRNOG00000011692.
ENSRNOT00000074393; ENSRNOP00000064286; ENSRNOG00000048688.
GeneIDi100912050.
293897.
KEGGirno:100912050.
rno:293897.
UCSCiRGD:1307313. rat.

Organism-specific databases

CTDi22943.
RGDi1307313. Dkk1.

Phylogenomic databases

GeneTreeiENSGT00390000007000.
KOiK02165.
OMAiRSSDCAT.
OrthoDBiEOG7K3TMT.
TreeFamiTF330916.

Enzyme and pathway databases

ReactomeiREACT_205336. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_212065. TCF dependent signaling in response to WNT.
REACT_249766. misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling.

Miscellaneous databases

NextBioi637227.
PROiD3Z9J1.

Family and domain databases

InterProiIPR006796. Dickkopf_N.
[Graphical view]
PfamiPF04706. Dickkopf_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.
  5. "Molecular cloning and bioinformatic analysis of DKK1."
    Hu L., Jiang G., Yang J., Liu S.
    Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. Ensembl
    Submitted (FEB-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3Z9J1_RAT
AccessioniPrimary (citable) accession number: D3Z9J1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.