ID   D3Z962_RAT              Unreviewed;       614 AA.
AC   D3Z962;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   27-MAR-2024, entry version 79.
DE   SubName: Full=Transforming, acidic coiled-coil containing protein 3 {ECO:0000313|Ensembl:ENSRNOP00000034933.5};
GN   Name=Tacc3 {ECO:0000313|Ensembl:ENSRNOP00000034933.5,
GN   ECO:0000313|RGD:1302948};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000034933.5, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000034933.5, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000034933.5,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000034933.5}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000034933.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the TACC family.
CC       {ECO:0000256|ARBA:ARBA00009423}.
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DR   AlphaFoldDB; D3Z962; -.
DR   STRING; 10116.ENSRNOP00000034933; -.
DR   jPOST; D3Z962; -.
DR   PaxDb; 10116-ENSRNOP00000034933; -.
DR   PeptideAtlas; D3Z962; -.
DR   Ensembl; ENSRNOT00000032972.5; ENSRNOP00000034933.5; ENSRNOG00000017259.8.
DR   AGR; RGD:1302948; -.
DR   RGD; 1302948; Tacc3.
DR   VEuPathDB; HostDB:ENSRNOG00000017259; -.
DR   eggNOG; ENOG502QQ1G; Eukaryota.
DR   GeneTree; ENSGT00940000158858; -.
DR   HOGENOM; CLU_013959_0_0_1; -.
DR   InParanoid; D3Z962; -.
DR   OrthoDB; 5406887at2759; -.
DR   PhylomeDB; D3Z962; -.
DR   TreeFam; TF333149; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000017259; Expressed in thymus and 19 other cell types or tissues.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR   GO; GO:0014069; C:postsynaptic density; ISO:RGD.
DR   GO; GO:0019904; F:protein domain specific binding; ISO:RGD.
DR   GO; GO:0030953; P:astral microtubule organization; ISO:RGD.
DR   GO; GO:0008283; P:cell population proliferation; ISO:RGD.
DR   GO; GO:0021987; P:cerebral cortex development; ISO:RGD.
DR   GO; GO:0030097; P:hemopoiesis; ISO:RGD.
DR   GO; GO:0022027; P:interkinetic nuclear migration; ISO:RGD.
DR   GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; ISO:RGD.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; ISO:RGD.
DR   GO; GO:1902850; P:microtubule cytoskeleton organization involved in mitosis; ISO:RGD.
DR   GO; GO:0007052; P:mitotic spindle organization; IEA:InterPro.
DR   GO; GO:0022008; P:neurogenesis; ISO:RGD.
DR   GO; GO:0051726; P:regulation of cell cycle; ISO:RGD.
DR   GO; GO:0032886; P:regulation of microtubule-based process; ISO:RGD.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; ISO:RGD.
DR   GO; GO:0001666; P:response to hypoxia; ISO:RGD.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   InterPro; IPR039915; TACC.
DR   InterPro; IPR007707; TACC_C.
DR   PANTHER; PTHR13924; TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2; 1.
DR   PANTHER; PTHR13924:SF4; TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF05010; TACC_C; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:D3Z962};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   DOMAIN          414..607
FT                   /note="Transforming acidic coiled-coil-containing protein
FT                   C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05010"
FT   REGION          165..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          423..496
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          536..609
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        178..235
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   614 AA;  68301 MW;  022DBF358C54CEA7 CRC64;
     MPIPIQFIQK CMFPGIDCTH LPTHCSRMNL HILTDENVPN EKSSESRDFL FSAPELTGRS
     SVLRLSQKEN VPPKNQAKAA KVTFQTPLRD PQTHRILSPN MTSKLEAPFA LDDSVGLQND
     HCVFLQKENQ LPVAPVDDVP VVQMAAEILK AEDELQEGIL NSLSPSAFTS FPDGELVTPP
     IEPMPEPSPQ GPEPLLDSEP VTPPVKPVLE PTPQGPEPLL DSEPVTPPVK PVLEPTPQGS
     EPLLDSEPVT LPVEPVPESS HQGPEPLLDS EPVTLPVEPV PESSHQGPEP LLDPKEESFR
     DPAEVLGAGA EVDYLEQFGT SSFKESAWRK QSLYLKFDPL LKESPLRSMP VPVAPVTNST
     QDTEESGSGN PTEAKLVDLD FLGGLDVPVS APPLCVLEPR GLLPAEPIVD VLKYSQKDLD
     AVVNVMQQEN LELRNKYEDL NTKYLEMGKI VDGFEKIVYK SMEEAEKQKE LAEDKIQKIL
     RERDQLTADL NSMEKSFSDL FKRFEKQKEV IEGYQKNEDS LKKCVEDYIV KIGKEGQRYQ
     ALKAHAEEKL KMANEEIAQV RSKAQAEALA LQASLRKAQL QIQSLEKTVE QKTKENDELN
     RICDELIAKM EKKI
//