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Protein

Ras-related protein R-Ras

Gene

Rras

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44GTPBy similarity9
Nucleotide bindingi83 – 87GTPBy similarity5
Nucleotide bindingi142 – 145GTPBy similarity4
Nucleotide bindingi172 – 174GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-416550. Sema4D mediated inhibition of cell attachment and migration.
R-RNO-442742. CREB phosphorylation through the activation of Ras.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein R-Ras
Alternative name(s):
p23
Gene namesi
Name:Rras
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311443. Rras.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

  • Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004084751 – 215Ras-related protein R-RasAdd BLAST215
PropeptideiPRO_0000408476216 – 218Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiD3Z8L7.
PeptideAtlasiD3Z8L7.
PRIDEiD3Z8L7.

PTM databases

SwissPalmiD3Z8L7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000037247.
GenevisibleiD3Z8L7. RN.

Interactioni

Subunit structurei

Interacts with PLCE1 (By similarity). Interacts (active GTP-bound form preferentially) with RGS14 (PubMed:19319189). Interacts with OSBPL3 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027809.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi58 – 66Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
InParanoidiD3Z8L7.
KOiK07829.
OMAiRSEASTF.
OrthoDBiEOG091G0UAU.
PhylomeDBiD3Z8L7.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3Z8L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGAASGTG RGRPRGGGPG PRDPPPGETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC TVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GNGFLLVFAI NDRQSFIEVS KLFTQILRVK DRDDFPIVLV GNKADLETQR
160 170 180 190 200
QVLRSEASSF SASHHMTYFE ASAKLRLNVD EAFEQLVRTV RKYQEQELPP
210
SPPSAPRKKD GRCPCVLL
Length:218
Mass (Da):23,909
Last modified:April 20, 2010 - v1
Checksum:i3410B3A4274EEEED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142N → S in FQ211166 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ211166 mRNA. No translation available.
CH473979 Genomic DNA. Translation: EDM07427.1.
RefSeqiNP_001101951.1. NM_001108481.1.
UniGeneiRn.71224.

Genome annotation databases

EnsembliENSRNOT00000027809; ENSRNOP00000027809; ENSRNOG00000037247.
GeneIDi361568.
KEGGirno:361568.
UCSCiRGD:1311443. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ211166 mRNA. No translation available.
CH473979 Genomic DNA. Translation: EDM07427.1.
RefSeqiNP_001101951.1. NM_001108481.1.
UniGeneiRn.71224.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027809.

PTM databases

SwissPalmiD3Z8L7.

Proteomic databases

PaxDbiD3Z8L7.
PeptideAtlasiD3Z8L7.
PRIDEiD3Z8L7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027809; ENSRNOP00000027809; ENSRNOG00000037247.
GeneIDi361568.
KEGGirno:361568.
UCSCiRGD:1311443. rat.

Organism-specific databases

CTDi6237.
RGDi1311443. Rras.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
InParanoidiD3Z8L7.
KOiK07829.
OMAiRSEASTF.
OrthoDBiEOG091G0UAU.
PhylomeDBiD3Z8L7.
TreeFamiTF312796.

Enzyme and pathway databases

ReactomeiR-RNO-416550. Sema4D mediated inhibition of cell attachment and migration.
R-RNO-442742. CREB phosphorylation through the activation of Ras.

Miscellaneous databases

PROiD3Z8L7.

Gene expression databases

BgeeiENSRNOG00000037247.
GenevisibleiD3Z8L7. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRAS_RAT
AccessioniPrimary (citable) accession number: D3Z8L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.