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Protein

Ras-related protein R-Ras

Gene

Rras

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44GTPBy similarity9
Nucleotide bindingi83 – 87GTPBy similarity5
Nucleotide bindingi142 – 145GTPBy similarity4
Nucleotide bindingi172 – 174GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-416550 Sema4D mediated inhibition of cell attachment and migration
R-RNO-442742 CREB phosphorylation through the activation of Ras

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein R-Ras
Alternative name(s):
p23
Gene namesi
Name:Rras
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311443 Rras

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004084751 – 215Ras-related protein R-RasAdd BLAST215
PropeptideiPRO_0000408476216 – 218Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiD3Z8L7
PeptideAtlasiD3Z8L7
PRIDEiD3Z8L7

PTM databases

SwissPalmiD3Z8L7

Expressioni

Gene expression databases

BgeeiENSRNOG00000037247
GenevisibleiD3Z8L7 RN

Interactioni

Subunit structurei

Interacts with PLCE1 (By similarity). Interacts (active GTP-bound form preferentially) with RGS14 (PubMed:19319189). Interacts with OSBPL3 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027809

Structurei

3D structure databases

SMRiD3Z8L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi58 – 66Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
InParanoidiD3Z8L7
KOiK07829
OMAiRSEASTF
OrthoDBiEOG091G0UAU
PhylomeDBiD3Z8L7
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3Z8L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGAASGTG RGRPRGGGPG PRDPPPGETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC TVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GNGFLLVFAI NDRQSFIEVS KLFTQILRVK DRDDFPIVLV GNKADLETQR
160 170 180 190 200
QVLRSEASSF SASHHMTYFE ASAKLRLNVD EAFEQLVRTV RKYQEQELPP
210
SPPSAPRKKD GRCPCVLL
Length:218
Mass (Da):23,909
Last modified:April 20, 2010 - v1
Checksum:i3410B3A4274EEEED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142N → S in FQ211166 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ211166 mRNA No translation available.
CH473979 Genomic DNA Translation: EDM07427.1
RefSeqiNP_001101951.1, NM_001108481.1
UniGeneiRn.71224

Genome annotation databases

EnsembliENSRNOT00000027809; ENSRNOP00000027809; ENSRNOG00000037247
GeneIDi361568
KEGGirno:361568
UCSCiRGD:1311443 rat

Similar proteinsi

Entry informationi

Entry nameiRRAS_RAT
AccessioniPrimary (citable) accession number: D3Z8L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health