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Protein
Submitted name:

ATR serine/threonine kinase

Gene

Atr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-176187 Activation of ATR in response to replication stress
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-5685938 HDR through Single Strand Annealing (SSA)
R-RNO-5693607 Processing of DNA double-strand break ends
R-RNO-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-RNO-6783310 Fanconi Anemia Pathway
R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation
R-RNO-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Submitted name:
ATR serine/threonine kinaseImported
Gene namesi
Name:AtrImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1305796 Atr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiD3Z822
PRIDEiD3Z822

PTM databases

PhosphoSitePlusiD3Z822

Expressioni

Gene expression databases

BgeeiENSRNOG00000010027

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043760

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati806 – 840HEATPROSITE-ProRule annotationAdd BLAST35
Domaini1635 – 2180FATInterPro annotationAdd BLAST546
Domaini2314 – 2636PI3K/PI4KInterPro annotationAdd BLAST323
Domaini2604 – 2636FATCInterPro annotationAdd BLAST33

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0890 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00830000128321
InParanoidiD3Z822
KOiK06640
OMAiWRRFPEH
OrthoDBiEOG091G013Q
TreeFamiTF101183

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.10.10, 1 hit
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR021133 HEAT_type_2
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR011990 TPR-like_helical_dom_sf
IPR012993 UME
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF08064 UME, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM00802 UME, 1 hit
SUPFAMiSSF48371 SSF48371, 6 hits
SSF48452 SSF48452, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS50077 HEAT_REPEAT, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

D3Z822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV
60 70 80 90 100
VALELVKKTD TQPTSVMLLD FIQHIMKSSP LMFVNVNGSQ GQNEAKDSCI
110 120 130 140 150
EFSHWIITRL LRIAATPSCH MLHKKICEVI CSLLFLFKSK NPAIFGVLTR
160 170 180 190 200
ELLYLFEDLI YLHKRNAVGD VMEWPVVVSR FLSRLDEHMG CLQPAPLQFM
210 220 230 240 250
NMQNVEFIEV TLLMVLIHIV PTVFFRRQEL LLWQIGCALL EHGSPKIRSL
260 270 280 290 300
AISLLTELFE LGGLPAQPAS TFFSLFLELL QHLIGMDADQ LKLYEEPLSK
310 320 330 340 350
LVKTLFPFEA EAYRNIEPVY LNVLLEKLRV MFEDRVLMRL KSDLLKAALC
360 370 380 390 400
HLLQYFLTFV PAGYESALQV RKVYVTDICR ALVDVLGVQT HVGYLLGPFY
410 420 430 440 450
AALKMESTEI IERIQCQAQQ ENLRGSNDGV SPKRRRLSSS LSSYKRPSRQ
460 470 480 490 500
SEEINHVDMD KKSILWNVLK QKAESLQISL ECGTLKNSVA EALEGITIVL
510 520 530 540 550
QLTALCTVHC SHQDMDGHNA KDCQHKYKKK PPVVITWMSL DFYTKVLKSC
560 570 580 590 600
KSLLESVQKH ELELVIDSVV RIYDALMYIQ VKSSFQDHVL EELCGMLSLP
610 620 630 640 650
WIYSYSDDNS LKMTTFATNL LRLSQRVWES YSPQAQSQCV FLLTLFPKRI
660 670 680 690 700
FLDWRTTVYN WALKSSHEVI RTSCVKGFFI LLQQENSCNQ IPKMLIDRVK
710 720 730 740 750
DDSHVVKKEF ASVLGQLVCT LHGMFYLTSS SVEPFFGPVD LFCKNLKATS
760 770 780 790 800
QHECSSSQVK ASVCKPFLFL LTKNTPSPVK LAFIDNLHHL CKHLDFQEDE
810 820 830 840 850
TEVKAVLGTL LNLMEDPDKD VRIAFSGNIK YILESLNSED GFIKELFVLR
860 870 880 890 900
MKEAYTHAQI SRSNELKDTL ILTTGDIGRA AKGDLIPFAL LHLLHCLLSK
910 920 930 940 950
SASVSGAAYT EIRALVAAKS VKLQNFFSQY KKPICQFLVE SLHSSQMTAL
960 970 980 990 1000
PSTPCQTAEM RKQHVAHHRE MALNTLSEIA NVFDFPDLNR FLTRTLQVLL
1010 1020 1030 1040 1050
PDLAAKASPA ASALIRTLGK QLNVNRREIL INNFKYIFSH LVCSCSKDEL
1060 1070 1080 1090 1100
ERALHYLKNE TEIELGSLLR QDFQGLHNEL LLRIGEHYQQ VFNGLSILAS
1110 1120 1130 1140 1150
FASSDDPYQG PRDITSPELM ADYLQPKLLG ILAFFNMQLL SSSVGIEDKK
1160 1170 1180 1190 1200
MALTSLMSLM KLMGPKHVSS VRVKMMTTLR TGLRFKDDFP ELCCRAWDCF
1210 1220 1230 1240 1250
VRCLDHAYLG PLLSHVIVAL LPLIQMQPKE TAAIFHYLII ENRVAVQDFL
1260 1270 1280 1290 1300
HEIYFLPDHP ELEKIKAVLQ EYRKETSEST DLQTTLQLSM KAIQHENVDV
1310 1320 1330 1340 1350
RIHALTSLKE TLYKNQEKLI KYATDSETVE PVISQLVTVI LKGCQDANSQ
1360 1370 1380 1390 1400
ARLLCGECLG ELGAIDPGRL DFSTTETQGK DFTFVTGVED LSFAYGLLME
1410 1420 1430 1440 1450
LTRAYLAYAD NSRAQDSAAY AIQELLSIYD CREMQSNGPG HQLWKRFPEH
1460 1470 1480 1490 1500
VREILEPHLN TRYKSSQKST DWSGVTKPIY LSKLGNNFAE WSSSWAGYLI
1510 1520 1530 1540 1550
TKVRDNLASK IFTCCSIMMK HDFKVTIYLL PHILVYVLLG CSQEDQQEVY
1560 1570 1580 1590 1600
AEIMAVLKHD DQHAISTQDS ASDLCQLSTQ TVFSMLDHLT QWARHKFQAL
1610 1620 1630 1640 1650
NAEKLAQNKP KGVSSVNFED YQSVTRFLDL IPQDTLAVAS FRSKAYTRAV
1660 1670 1680 1690 1700
MHFESFITEK KQNIQKHLGF LQKLYAAMHE PDGVAGVSAI RKAEPSLKEQ
1710 1720 1730 1740 1750
ILEHESIGLL RDATACYDRA IQLEPDQIIH YHGVVKSMLG LGQLSTVITQ
1760 1770 1780 1790 1800
VNGVHANRSE WTDELNTYRV EAAWKLSQWD LVENYLAADG KSTTWSVRLG
1810 1820 1830 1840 1850
QLLLSAKKRD TTAFYDTLKL VRAEQIVPLS AASFERGSYQ RGYEFIVRLH
1860 1870 1880 1890 1900
MLCELEHSLK PLFHKFPGDS CNEDSLNWAA RLEMTQNSYR AKEPILALRR
1910 1920 1930 1940 1950
ALLSLNKRPD YNEMVGECWL QSARVARKAG HHQTAYNALL NAGESRLAEL
1960 1970 1980 1990 2000
YVERAKWLWS KGDVHQALIV LQKGVELCFP ENKSPTESKH MLIHGRATLL
2010 2020 2030 2040 2050
VGRFMEETAN FESNAIMKKY KDVTLFLPEW EDGHFYLAKY YDKLMPMVTD
2060 2070 2080 2090 2100
NKMEKQGDLI RYIVLHFGRS LQYGNQFIYQ SMPRMLSLWL DFGAKAYEWE
2110 2120 2130 2140 2150
KGGRSDRLQM RNDLAKINSV LTEHTNRLAP YQFLTAFSQL ISRICHSHDE
2160 2170 2180 2190 2200
VFVVLMEIIA KVFLAYPQQA MWMMTAVSKS SYPMRVNRCK EILTKAIHMK
2210 2220 2230 2240 2250
KSLEKFVGDA TRLTDKLLEL CNKSVDGSNS TLSMSTHFKM LKKLVEDPTF
2260 2270 2280 2290 2300
SEILIPLQSV MIPTLPSILG AHANHDPFPG HWAYLAGFDD VVEILSSLQK
2310 2320 2330 2340 2350
PKKISLKGSD GKFYIMMCKP KDDLRKDCRL MEFNSLINKS LRKDAESRRR
2360 2370 2380 2390 2400
ELHIRTYAVI PLNDECGIIE WVNNTAGLRP ILTKLYKEKG VYMTGKELRQ
2410 2420 2430 2440 2450
CMLPKSAALS EKLKVFQEIL LPRHPPVFHE WFLRTFPDPT SWYSSRSAYC
2460 2470 2480 2490 2500
RSTAVMSMVG YILGLGDRHG ENILFDSFTG ECVHVDFNCL FNKGETFEVP
2510 2520 2530 2540 2550
EIVPFRLTHN MVNGMGPMGT EGLFRRACEV TLRLMRDQRE PLMSVLKTFL
2560 2570 2580 2590 2600
HDPLVEWSKP VKGHSKAPPN ETGEVVNEKA KTHVLDIEQR LQGVIKTRNR
2610 2620 2630
VTGLPLSIEG HVHYLIQEAT DENLLCQMYL GWTPYM
Length:2,636
Mass (Da):300,501
Last modified:July 22, 2015 - v3
Checksum:i7BA894850B510A07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07071182 Genomic DNA No translation available.
AABR07071183 Genomic DNA No translation available.
AABR07071184 Genomic DNA No translation available.
RefSeqiXP_003750609.1, XM_003750561.4
XP_003754493.1, XM_003754445.4

Genome annotation databases

EnsembliENSRNOT00000049967; ENSRNOP00000043760; ENSRNOG00000010027
GeneIDi685055
KEGGirno:685055

Similar proteinsi

Entry informationi

Entry nameiD3Z822_RAT
AccessioniPrimary (citable) accession number: D3Z822
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: March 28, 2018
This is version 68 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health