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Protein
Submitted name:

Histone-lysine N-methyltransferase EZH2

Gene

Ezh2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferase EZH2Imported
Gene namesi
Name:Ezh2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107940. Ezh2.

PTM / Processingi

Proteomic databases

PRIDEiD3Z774.

Expressioni

Gene expression databases

BgeeiD3Z774.
ExpressionAtlasiD3Z774. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3Z774.
SMRiD3Z774. Positions 40-68, 481-690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini464 – 566103CXCInterPro annotationAdd
BLAST
Domaini573 – 688116SETInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119228.
HOGENOMiHOG000008176.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH1/EZH2.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM01114. CXC. 1 hit.
SM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Z774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKT MFSSNRQKIL
60 70 80 90 100
ERTETLNQEW KQRRIQPVHI MTSVSSLRGT REVEDETVLH NIPYMGDEVL
110 120 130 140 150
DQDGTFIEEL IKNYDGKVHG DRECGFINDE IFVELVNALG QYNDDDDDDD
160 170 180 190 200
GDDPDEREEK QKDLEDNRDD KETCPPRKFP ADKIFEAISS MFPDKGTAEE
210 220 230 240 250
LKEKYKELTE QQLPGALPPE CTPNIDGPNA KSVQREQSLH SFHTLFCRRC
260 270 280 290 300
FKYDCFLHPF HATPNTYKRK NTETALDNKP CGPQCYQHLE GAKEFAAALT
310 320 330 340 350
AERIKTPPKR PGGRRRGRLP NNSSRPSTPT ISVLESKDTD SDREAGTETG
360 370 380 390 400
GENNDKEEEE KKDETSSSSE ANSRCQTPIK MKPNIEPPEN VEWSGAEASM
410 420 430 440 450
FRVLIGTYYD NFCAIARLIG TKTCRQVYEF RVKESSIIAP VPTEDVDTPP
460 470 480 490 500
RKKKRKHRLW AAHCRKIQLK KDGSSNHVYN YQPCDHPRQP CDSSCPCVIA
510 520 530 540 550
QNFCEKFCQC SSECQNRFPG CRCKAQCNTK QCPCYLAVRE CDPDLCLTCG
560 570 580 590 600
AADHWDSKNV SCKNCSIQRG SKKHLLLAPS DVAGWGIFIK DPVQKNEFIS
610 620 630 640 650
EYCGEIISQD EADRRGKVYD KYMCSFLFNL NNDFVVDATR KGNKIRFANH
660 670 680 690 700
SVNPNCYAKV MMVNGDHRIG IFAKRAIQTG EELFFDYRYS QADALKYVGI

EREMEIP
Length:707
Mass (Da):80,997
Last modified:April 20, 2010 - v1
Checksum:iF1304E7A0614FBB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154015 Genomic DNA. No translation available.
AC155652 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000114616; ENSMUSP00000110263; ENSMUSG00000029687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154015 Genomic DNA. No translation available.
AC155652 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD3Z774.
SMRiD3Z774. Positions 40-68, 481-690.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD3Z774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114616; ENSMUSP00000110263; ENSMUSG00000029687.

Organism-specific databases

MGIiMGI:107940. Ezh2.

Phylogenomic databases

GeneTreeiENSGT00760000119228.
HOGENOMiHOG000008176.

Miscellaneous databases

ChiTaRSiEzh2. mouse.
NextBioi35551618.
SOURCEiSearch...

Gene expression databases

BgeeiD3Z774.
ExpressionAtlasiD3Z774. baseline and differential.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH1/EZH2.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM01114. CXC. 1 hit.
SM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z774_MOUSE
AccessioniPrimary (citable) accession number: D3Z774
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 11, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.