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Protein

Inositol-1-monophosphatase

Gene

Impa1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (Isyna1)
  2. Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol monophosphatase 1 (Impa1), Inositol-1-monophosphatase (Impa2), Inositol monophosphatase 2 (Impa2), Inositol monophosphatase 3 (Impad1), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa2)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
UniPathwayiUPA00823; UER00788.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-1-monophosphataseUniRule annotation (EC:3.1.3.25UniRule annotation)
Gene namesi
Name:Impa1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1933158. Impa1.

PTM / Processingi

Proteomic databases

PaxDbiD3Z703.
PeptideAtlasiD3Z703.
PRIDEiD3Z703.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027531.
ExpressionAtlasiD3Z703. baseline and differential.

Structurei

3D structure databases

SMRiD3Z703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the inositol monophosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2951. Eukaryota.
COG0483. LUCA.
GeneTreeiENSGT00390000014699.

Family and domain databases

InterProiView protein in InterPro
IPR033942. IMPase.
IPR000760. Inositol_monophosphatase-like.
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiView protein in Pfam
PF00459. Inositol_P. 1 hit.
PRINTSiPR00377. IMPHPHTASES.

Sequencei

Sequence statusi: Fragment.

D3Z703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPALPKPSG LYTIMADPWQ ECMDYAVILA RQAGEMIREA LKNEMDVMIK
60 70 80
SSPADLVTVT DQKVEKMLMS SIKEKYPCHS FIGEESVAA
Length:89
Mass (Da):9,897
Last modified:October 5, 2016 - v8
Checksum:i83A7BD0A0578BFAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei89Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123726 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000128912; ENSMUSP00000116088; ENSMUSG00000027531.
UCSCiuc008opq.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD3Z703_MOUSE
AccessioniPrimary (citable) accession number: D3Z703
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: October 5, 2016
Last modified: July 5, 2017
This is version 56 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported