Foxp1

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	494 – 567	Fork-headPROSITE-ProRule annotationAdd BLAST		74

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

cardiac muscle cell differentiation Source: Ensembl
cardiovascular system development Source: Ensembl
immunoglobulin V(D)J recombination Source: Ensembl
interleukin-21 secretion Source: Ensembl
in utero embryonic development Source: Ensembl
lung secretory cell differentiation Source: Ensembl
motor neuron axon guidance Source: Ensembl
negative regulation of lung goblet cell differentiation Source: Ensembl
negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
positive regulation of cardiac muscle cell differentiation Source: Ensembl
positive regulation of epithelial cell proliferation Source: Ensembl
positive regulation of immunoglobulin production Source: Ensembl
positive regulation of mesenchymal cell proliferation Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
pre-B cell differentiation Source: Ensembl
regulation of cardiac muscle cell proliferation Source: Ensembl
sarcomere organization Source: Ensembl
skeletal muscle tissue development Source: Ensembl
smooth muscle tissue development Source: Ensembl
T follicular helper cell differentiation Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW
ventral spinal cord development Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological process	TranscriptionSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Forkhead box protein P1Imported
Gene namesⁱ	Name:Foxp1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:1914004. Foxp1.

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Automatic assertion according to rulesⁱ
- PROSITE-ProRule:PRU00089
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00582275

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	D3Z6Q3.
PaxDbⁱ	D3Z6Q3.
PeptideAtlas More...PeptideAtlasⁱ	D3Z6Q3.
PRIDEⁱ	D3Z6Q3.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030067.
ExpressionAtlasⁱ	D3Z6Q3. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	D3Z6Q3.
SMRⁱ	D3Z6Q3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	494 – 567	Fork-head DNA-bindingInterPro annotationAdd BLAST		74

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	62 – 107	Sequence analysisAdd BLAST		46

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG4385. Eukaryota. COG5025. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00800000124014.
HOGENOMⁱ	HOG000092089.
OMAⁱ	EMNGAMD.
PhylomeDBⁱ	D3Z6Q3.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001766. Fork_head_dom. IPR032354. FOXP-CC. IPR030456. TF_fork_head_CS_2. IPR011991. WHTH_DNA-bd_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250. Forkhead. 1 hit. PF16159. FOXP-CC. 1 hit.
PRINTSⁱ	PR00053. FORKHEAD.
SMARTⁱ	View protein in SMART SM00339. FH. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

D3Z6Q3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMQESGSETK SNGSAIQNGS SGGNHLLECG ALRDTRSNGE APAVDLGAAD 
        60         70         80         90        100
LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 
       110        120        130        140        150
QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV 
       160        170        180        190        200
LSPQQLQVLL QQQQALMLQQ QLQEFYKKQQ EQLQLQLLQQ QHAGKQPKEQ 
       210        220        230        240        250
QQVATQQLAF QQQLLQMQQL QQQHLLSLQR QGLLTIQPGQ PALPLQPLAQ 
       260        270        280        290        300
GMIPTELQQL WKEVTSAHTA EETTSSNHSS LDLTSTCVSS SAPSKSSLIM 
       310        320        330        340        350
NPHASTNGQL SVHTPKRESL SHEEHPHSHP LYGHGVCKWP GCEAVCDDFP 
       360        370        380        390        400
AFLKHLNSEH ALDDRSTAQC RVQMQVVQQL ELQLAKDKER LQAMMTHLHV 
       410        420        430        440        450
KSTEPKAAPQ PLNLVSSVTL SKSASEASPQ SLPHTPTTPT APLTPVTQGP 
       460        470        480        490        500
SVITTTSMHT VGPIRRRYSD KYNVPISSAD IAQNQEFYKN AEVRPPFTYA 
       510        520        530        540        550
SLIRQAILES PEKQLTLNEI YNWFTRMFAY FRRNAATWKN AVRHNLSLHK 
       560        570        580        590        600
CFVRVENVKG AVWTVDEVEF QKRRPQKISG NPSLIKNMQS SHAYCTPLNA 
       610        620        630        640        650
ALQASMAENS IPLYTTASMG NPTLGSLASA IREELNGAME HTNSNESDSS 
       660        670        680        690        700
PGRSPMQAVH PIHVKEEPLD PEEAEGPLSL VTTANHSPDF DHDRDYEDEP 

VNEDME

Length:706

Mass (Da):78,961

Last modified:April 20, 2010 - v1

Checksum:ⁱ5DFE52B3577CB451

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC125137 Genomic DNA. No translation available. AC132579 Genomic DNA. No translation available. AC152987 Genomic DNA. No translation available. AC155839 Genomic DNA. No translation available. AC163199 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_006505377.1. XM_006505314.3.
UniGeneⁱ	Mm.234965. Mm.392884. Mm.485266. Mm.487716.

Genome annotation databases

Ensemblⁱ	ENSMUST00000113328; ENSMUSP00000108954; ENSMUSG00000030067.
GeneIDⁱ	108655.
UCSC genome browser More...UCSCⁱ	uc009dbk.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC125137 Genomic DNA. No translation available. AC132579 Genomic DNA. No translation available. AC152987 Genomic DNA. No translation available. AC155839 Genomic DNA. No translation available. AC163199 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_006505377.1. XM_006505314.3.
UniGeneⁱ	Mm.234965. Mm.392884. Mm.485266. Mm.487716.

3D structure databases

ProteinModelPortalⁱ	D3Z6Q3.
SMRⁱ	D3Z6Q3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	D3Z6Q3.
PaxDbⁱ	D3Z6Q3.
PeptideAtlas More...PeptideAtlasⁱ	D3Z6Q3.
PRIDEⁱ	D3Z6Q3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000113328; ENSMUSP00000108954; ENSMUSG00000030067.
GeneIDⁱ	108655.
UCSC genome browser More...UCSCⁱ	uc009dbk.2. mouse.

Organism-specific databases

CTDⁱ	27086.
MGIⁱ	MGI:1914004. Foxp1.

Phylogenomic databases

eggNOGⁱ	KOG4385. Eukaryota. COG5025. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00800000124014.
HOGENOMⁱ	HOG000092089.
OMAⁱ	EMNGAMD.
PhylomeDBⁱ	D3Z6Q3.

Miscellaneous databases

ChiTaRSⁱ	Foxp1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030067.
ExpressionAtlasⁱ	D3Z6Q3. baseline and differential.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001766. Fork_head_dom. IPR032354. FOXP-CC. IPR030456. TF_fork_head_CS_2. IPR011991. WHTH_DNA-bd_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250. Forkhead. 1 hit. PF16159. FOXP-CC. 1 hit.
PRINTSⁱ	PR00053. FORKHEAD.
SMARTⁱ	View protein in SMART SM00339. FH. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3Z6Q3_MOUSE
Accessionⁱ	D3Z6Q3Primary (citable) accession number: D3Z6Q3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	July 5, 2017
	This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3Z6Q3 (D3Z6Q3_MOUSE)

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Forkhead box protein P1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ