UniProtKB - D3Z6Q3 (D3Z6Q3_MOUSE)
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Protein
Submitted name:
Forkhead box protein P1
Gene
Foxp1
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 494 – 567 | Fork-headPROSITE-ProRule annotationAdd BLAST | 74 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl
GO - Biological processi
- cardiac muscle cell differentiation Source: Ensembl
- cardiovascular system development Source: Ensembl
- immunoglobulin V(D)J recombination Source: Ensembl
- interleukin-21 secretion Source: Ensembl
- in utero embryonic development Source: Ensembl
- lung secretory cell differentiation Source: Ensembl
- motor neuron axon guidance Source: Ensembl
- negative regulation of lung goblet cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of cardiac muscle cell differentiation Source: Ensembl
- positive regulation of epithelial cell proliferation Source: Ensembl
- positive regulation of immunoglobulin production Source: Ensembl
- positive regulation of mesenchymal cell proliferation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- pre-B cell differentiation Source: Ensembl
- regulation of cardiac muscle cell proliferation Source: Ensembl
- sarcomere organization Source: Ensembl
- skeletal muscle tissue development Source: Ensembl
- smooth muscle tissue development Source: Ensembl
- T follicular helper cell differentiation Source: Ensembl
- transcription, DNA-templated Source: UniProtKB-KW
- ventral spinal cord development Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationSAAS annotation |
Biological process | TranscriptionSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Forkhead box protein P1Imported |
Gene namesi | Name:Foxp1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914004. Foxp1. |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationSAAS annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000030067. |
ExpressionAtlasi | D3Z6Q3. baseline and differential. |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
Structurei
3D structure databases
ProteinModelPortali | D3Z6Q3. |
SMRi | D3Z6Q3. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 494 – 567 | Fork-headInterPro annotationAdd BLAST | 74 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 62 – 107 | Sequence analysisAdd BLAST | 46 | |
Coiled coili | 377 – 397 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG4385. Eukaryota. COG5025. LUCA. |
GeneTreei | ENSGT00910000144016. |
HOGENOMi | HOG000092089. |
OMAi | VCEDFPS. |
PhylomeDBi | D3Z6Q3. |
Family and domain databases
CDDi | cd00059. FH. 1 hit. |
Gene3Di | 1.10.10.10. 1 hit. |
InterProi | View protein in InterPro IPR001766. Fork_head_dom. IPR032354. FOXP-CC. IPR030456. TF_fork_head_CS_2. IPR036388. WH-like_DNA-bd_sf. IPR036390. WH_DNA-bd_sf. |
Pfami | View protein in Pfam PF00250. Forkhead. 1 hit. PF16159. FOXP-CC. 1 hit. |
PRINTSi | PR00053. FORKHEAD. |
SMARTi | View protein in SMART SM00339. FH. 1 hit. |
SUPFAMi | SSF46785. SSF46785. 1 hit. |
PROSITEi | View protein in PROSITE PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. |
i Sequence
Sequence statusi: Complete.
D3Z6Q3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMQESGSETK SNGSAIQNGS SGGNHLLECG ALRDTRSNGE APAVDLGAAD
60 70 80 90 100
LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
110 120 130 140 150
QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV
160 170 180 190 200
LSPQQLQVLL QQQQALMLQQ QLQEFYKKQQ EQLQLQLLQQ QHAGKQPKEQ
210 220 230 240 250
QQVATQQLAF QQQLLQMQQL QQQHLLSLQR QGLLTIQPGQ PALPLQPLAQ
260 270 280 290 300
GMIPTELQQL WKEVTSAHTA EETTSSNHSS LDLTSTCVSS SAPSKSSLIM
310 320 330 340 350
NPHASTNGQL SVHTPKRESL SHEEHPHSHP LYGHGVCKWP GCEAVCDDFP
360 370 380 390 400
AFLKHLNSEH ALDDRSTAQC RVQMQVVQQL ELQLAKDKER LQAMMTHLHV
410 420 430 440 450
KSTEPKAAPQ PLNLVSSVTL SKSASEASPQ SLPHTPTTPT APLTPVTQGP
460 470 480 490 500
SVITTTSMHT VGPIRRRYSD KYNVPISSAD IAQNQEFYKN AEVRPPFTYA
510 520 530 540 550
SLIRQAILES PEKQLTLNEI YNWFTRMFAY FRRNAATWKN AVRHNLSLHK
560 570 580 590 600
CFVRVENVKG AVWTVDEVEF QKRRPQKISG NPSLIKNMQS SHAYCTPLNA
610 620 630 640 650
ALQASMAENS IPLYTTASMG NPTLGSLASA IREELNGAME HTNSNESDSS
660 670 680 690 700
PGRSPMQAVH PIHVKEEPLD PEEAEGPLSL VTTANHSPDF DHDRDYEDEP
VNEDME
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC125137 Genomic DNA. No translation available. AC132579 Genomic DNA. No translation available. AC152987 Genomic DNA. No translation available. AC155839 Genomic DNA. No translation available. AC163199 Genomic DNA. No translation available. |
RefSeqi | XP_006505377.1. XM_006505314.3. |
UniGenei | Mm.234965. Mm.392884. Mm.485266. Mm.487716. |
Genome annotation databases
Ensembli | ENSMUST00000113328; ENSMUSP00000108954; ENSMUSG00000030067. |
GeneIDi | 108655. |
UCSCi | uc009dbk.2. mouse. |
Similar proteinsi
Entry informationi
Entry namei | D3Z6Q3_MOUSE | |
Accessioni | D3Z6Q3Primary (citable) accession number: D3Z6Q3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | March 28, 2018 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |