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Protein

Protein kinase C

Gene

Prkd3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei510 – 5101ATPUniRule annotation
Active sitei604 – 6041Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi487 – 4959ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein kinase C activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CSAAS annotation (EC:2.7.11.13SAAS annotation)
Gene namesi
Name:Prkd3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1922542. Prkd3.

PTM / Processingi

Proteomic databases

MaxQBiD3Z6I0.
PRIDEiD3Z6I0.

Expressioni

Gene expression databases

BgeeiD3Z6I0.
ExpressionAtlasiD3Z6I0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3Z6I0.
SMRiD3Z6I0. Positions 60-109, 177-226, 319-437, 450-765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains PH domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121901.
HOGENOMiHOG000015135.
KOiK06070.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR015727. Protein_Kinase_C_mu-related.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22968. PTHR22968. 1 hit.
PfamiPF00130. C1_1. 2 hits.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000552. PKC_mu_nu_D2. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00233. PH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Z6I0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPECGFFGM YDKILLFRHD MNSENILQLI TSADEIHEGD LVEVVLSALA
60 70 80 90 100
TVEDFQIRPH ALYVHSYKAP TFCDYCGEML WGLVRQGLKC EGCGLNYHKR
110 120 130 140 150
CAFKIPNNCS GVRKRRLSNV SLPGPGLSVP RPLQPECVPL LSEESHTHQE
160 170 180 190 200
PSKRIPSWSG RPIWMEKMVM CRVKVPHTFA VHSYGRPTIC QYCKRLLKGL
210 220 230 240 250
FRQGMQCKDC KFNCHKRCAS KVPRDCLGEV TFNGEPCSVG TDADMPMDID
260 270 280 290 300
SSDVNSDGSR GLDDSEEPSP PEDKMFFLDP TDLDVERDEE TVKTISPSTS
310 320 330 340 350
NNIPLMRVVQ SIKHTKRRSS TVVKEGWMVH YTSRDNLRKR HYWRLDSKCL
360 370 380 390 400
TLFQNESGSK YYKEIPLSEI LRVSSPQDFT SISQGSNPHC FEIITDTVVY
410 420 430 440 450
FVGENNGSSS HNPVLAATGV GLDVAQSWEK AIRQALMPVT PQASVCTSPG
460 470 480 490 500
QGKDHKDLAT SISVSNCQVQ ENVDISSVYQ IFADEVLGSG QFGIVYGGKH
510 520 530 540 550
RKTGRDVAIK VIDKMRFPTK QESQLRNEVA ILQNLHHPGI VNLECMFETP
560 570 580 590 600
ERVFVVMEKL HGDMLEMILS SEKSRLPERI TKFMVTQILV ALRNLHFKNI
610 620 630 640 650
VHCDLKPENV LLASAEPFPQ VKLCDFGFAR IIGEKSFRRS VVGTPAYLAP
660 670 680 690 700
EVLRSKGYNR SLDMWSVGVI VYVSLSGTFP FNEDEDINDQ IQNAAFMYPP
710 720 730 740 750
NPWREISSEA IDLINNLLQV KMRKRYSVDK SLSHPWLQDY QTWLDLREFE
760 770 780 790
TRIGERYITH ESDDARWEIH AYTHNLEYPK HFIMAPNPDD MEEDP
Length:795
Mass (Da):90,450
Last modified:April 20, 2010 - v1
Checksum:iDD53C2340C11658C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151293 Genomic DNA. No translation available.
AC154274 Genomic DNA. No translation available.
RefSeqiNP_001164476.1. NM_001171005.1.
UniGeneiMm.252776.

Genome annotation databases

EnsembliENSMUST00000118768; ENSMUSP00000113232; ENSMUSG00000024070.
GeneIDi75292.
KEGGimmu:75292.
UCSCiuc008dpq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151293 Genomic DNA. No translation available.
AC154274 Genomic DNA. No translation available.
RefSeqiNP_001164476.1. NM_001171005.1.
UniGeneiMm.252776.

3D structure databases

ProteinModelPortaliD3Z6I0.
SMRiD3Z6I0. Positions 60-109, 177-226, 319-437, 450-765.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD3Z6I0.
PRIDEiD3Z6I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118768; ENSMUSP00000113232; ENSMUSG00000024070.
GeneIDi75292.
KEGGimmu:75292.
UCSCiuc008dpq.2. mouse.

Organism-specific databases

CTDi23683.
MGIiMGI:1922542. Prkd3.

Phylogenomic databases

GeneTreeiENSGT00780000121901.
HOGENOMiHOG000015135.
KOiK06070.

Miscellaneous databases

ChiTaRSiPrkd3. mouse.
NextBioi342658.
SOURCEiSearch...

Gene expression databases

BgeeiD3Z6I0.
ExpressionAtlasiD3Z6I0. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR015727. Protein_Kinase_C_mu-related.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22968. PTHR22968. 1 hit.
PfamiPF00130. C1_1. 2 hits.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000552. PKC_mu_nu_D2. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00233. PH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z6I0_MOUSE
AccessioniPrimary (citable) accession number: D3Z6I0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.