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D3Z5U6

- D3Z5U6_MOUSE

UniProt

D3Z5U6 - D3Z5U6_MOUSE

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Protein
Submitted name:

SHC-transforming protein 1

Gene

Shc1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. actin cytoskeleton reorganization Source: MGI
  2. activation of MAPK activity Source: MGI
  3. angiogenesis Source: MGI
  4. heart development Source: MGI
  5. MAPK cascade Source: Ensembl
  6. single organismal cell-cell adhesion Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SHC-transforming protein 1Imported
Gene namesi
Name:Shc1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:98296. Shc1.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD3Z5U6.
ExpressionAtlasiD3Z5U6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3Z5U6.
SMRiD3Z5U6. Positions 1-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
[Graphical view]
PRINTSiPR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
[Graphical view]
PROSITEiPS01179. PID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3Z5U6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV
60 70 80 90 100
SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK
110 120 130 140 150
PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI
160 170 180 190 200
SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL
210 220 230 240 250
RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL
260 270 280
GGVVDMRLRE GAARPTLPSA QMSSHLGATL
Length:280
Mass (Da):30,623
Last modified:April 20, 2010 - v1
Checksum:i72095BDE31365A7B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei280 – 2801Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC171273 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000137793; ENSMUSP00000117190; ENSMUSG00000042626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC171273 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali D3Z5U6.
SMRi D3Z5U6. Positions 1-207.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000137793 ; ENSMUSP00000117190 ; ENSMUSG00000042626 .

Organism-specific databases

MGIi MGI:98296. Shc1.

Phylogenomic databases

GeneTreei ENSGT00390000018860.
HOGENOMi HOG000231974.

Miscellaneous databases

ChiTaRSi SHC1. mouse.
NextBioi 35551317.
SOURCEi Search...

Gene expression databases

Bgeei D3Z5U6.
ExpressionAtlasi D3Z5U6. baseline and differential.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR029586. Shc1/ShcA.
[Graphical view ]
PANTHERi PTHR10337:SF2. PTHR10337:SF2. 1 hit.
Pfami PF00640. PID. 1 hit.
[Graphical view ]
PRINTSi PR00629. SHCPIDOMAIN.
SMARTi SM00462. PTB. 1 hit.
[Graphical view ]
PROSITEi PS01179. PID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiD3Z5U6_MOUSE
AccessioniPrimary (citable) accession number: D3Z5U6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3