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D3Z5U6

- D3Z5U6_MOUSE

UniProt

D3Z5U6 - D3Z5U6_MOUSE

Protein
Submitted name:

SHC-transforming protein 1

Gene

Shc1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: MGI
    2. activation of MAPK activity Source: MGI
    3. angiogenesis Source: MGI
    4. heart development Source: MGI
    5. MAPK cascade Source: Ensembl
    6. single organismal cell-cell adhesion Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    SHC-transforming protein 1Imported
    Gene namesi
    Name:Shc1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:98296. Shc1.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiD3Z5U6.
    BgeeiD3Z5U6.

    Structurei

    3D structure databases

    ProteinModelPortaliD3Z5U6.
    SMRiD3Z5U6. Positions 1-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000018860.
    HOGENOMiHOG000231974.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    [Graphical view]
    PRINTSiPR00629. SHCPIDOMAIN.
    SMARTiSM00462. PTB. 1 hit.
    [Graphical view]
    PROSITEiPS01179. PID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D3Z5U6-1 [UniParc]FASTAAdd to Basket

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    MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV    50
    SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK 100
    PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI 150
    SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL 200
    RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL 250
    GGVVDMRLRE GAARPTLPSA QMSSHLGATL 280
    Length:280
    Mass (Da):30,623
    Last modified:April 20, 2010 - v1
    Checksum:i72095BDE31365A7B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei280 – 2801Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC171273 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000137793; ENSMUSP00000117190; ENSMUSG00000042626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC171273 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali D3Z5U6.
    SMRi D3Z5U6. Positions 1-207.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000137793 ; ENSMUSP00000117190 ; ENSMUSG00000042626 .

    Organism-specific databases

    MGIi MGI:98296. Shc1.

    Phylogenomic databases

    GeneTreei ENSGT00390000018860.
    HOGENOMi HOG000231974.

    Miscellaneous databases

    ChiTaRSi SHC1. mouse.
    NextBioi 35551317.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi D3Z5U6.
    Bgeei D3Z5U6.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    [Graphical view ]
    PRINTSi PR00629. SHCPIDOMAIN.
    SMARTi SM00462. PTB. 1 hit.
    [Graphical view ]
    PROSITEi PS01179. PID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiD3Z5U6_MOUSE
    AccessioniPrimary (citable) accession number: D3Z5U6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3