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Protein
Submitted name:

1-phosphatidylinositol 3-phosphate 5-kinase

Gene

Pikfyve

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
1-phosphatidylinositol 3-phosphate 5-kinaseImported
Gene namesi
Name:PikfyveImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1335106. Pikfyve.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiD3Z5N5.
PaxDbiD3Z5N5.

Expressioni

Gene expression databases

BgeeiD3Z5N5.
ExpressionAtlasiD3Z5N5. baseline and differential.
GenevisibleiD3Z5N5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079926.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 22961FYVE-typeInterPro annotationAdd
BLAST
Domaini376 – 45176DEPInterPro annotationAdd
BLAST
Domaini1712 – 2038327PIPKInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains PIPK domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG410IMP3. Eukaryota.
KOG0230. Eukaryota.
COG0459. LUCA.
COG5253. LUCA.
GeneTreeiENSGT00840000129741.
HOGENOMiHOG000059273.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.260.10. 2 hits.
3.30.40.10. 1 hit.
3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR002423. Cpn60/TCP-1.
IPR000591. DEP_dom.
IPR027409. GroEL-like_apical_dom.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR027410. TCP-1-like_intermed.
IPR011991. WHTH_DNA-bd_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
PF00610. DEP. 1 hit.
PF01363. FYVE. 1 hit.
PF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00064. FYVE. 1 hit.
SM00330. PIPKc. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52029. SSF52029. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS51455. PIPK. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Z5N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDDKSSPT LDSANDLPRS PASPSHLTHF KPLTPDQDEP PFKSAYSSFV
60 70 80 90 100
NLFRFNKERG EGGQGEQQSP SSSWASPQIP SRTQSVRSPV PYKKQLNEEL
110 120 130 140 150
HRRSSVLENT LPHPQESTDS RRKAEPACGG HDPRTAVQLR SLSTVLKRLK
160 170 180 190 200
EIMEGKSQDS DLKQYWMPDS QCKECYDCSE KFTTFRRRHH CRLCGQIFCS
210 220 230 240 250
RCCNQEIPGK FMGYTGDLRA CTYCRKIALS YAHSTDSNSI GEDLNALSDS
260 270 280 290 300
TCSVSILDPS EPRTPVGSRK ASRNIFLEDD LAWQSLIHPD SSNSALSTRL
310 320 330 340 350
VSVQEDAGKS PARNRSASIT NLSLDRSGSP MVPSYETSVS PQANRNYIRT
360 370 380 390 400
ETTEDERKIL LDSAQLKDLW KKICHHTSGM EFQDHRYWLR THPNCIVGKE
410 420 430 440 450
LVNWLIRNGH IATRAQAIAI GQAMVDGRWL DCVSHHDQLF RDEYALYRPL
460 470 480 490 500
QSTEFSETPS PDSDSVNSVE GHSEPSWFKD IKFDDSDTEQ IAEEGDDNLA
510 520 530 540 550
KYLVSDTGGQ QLSISDAFIK ESLFNRRVEE KSKELPFTPL GWHHNNLELL
560 570 580 590 600
REENEEKQAM ERLLSANHNH MMALLQQLLQ NESLSSSWRD IIVSLVCQVV
610 620 630 640 650
QTVRPDVKHQ DDDMDIRQFV HIKKIPGGKK FDSVVVNGFV CTKNIAHKKM
660 670 680 690 700
NSCIKNPKIL LLKCSIEYLY REETKFTCID PIVLQEREFL KNYVQRIVDV
710 720 730 740 750
RPTLVLVEKT VSRIAQDMLL EHGITLVINV KSQVLERISR MTQGDLVVSM
760 770 780 790 800
DQLLTKPHLG TCHKFYMQIF QLPNEQTKTL MFFEGCPQHL GCTIKLRGGS
810 820 830 840 850
DYELARVKEI LIFMICVAYH SQLEISFLMD EFAMPPTLMQ SPSFHLLTEG
860 870 880 890 900
RGEEGASQEQ VSGSSLPQDP ECPREALSSE DSTLLESRTV LEKGELDNKS
910 920 930 940 950
IPQAVASLKH QDYTTPTCPA GIPCALFALV PESLLPLHMD QQDAVGNEQP
960 970 980 990 1000
ETSQQTDEQQ DPKSQMKAFR DPLQDDTGMY VTEEVTSSED QRKTYALTFK
1010 1020 1030 1040 1050
QELKDVILCI SPVITFREPF LLTEKGMRCS TRDYFPEQIY WSPLLNKEVK
1060 1070 1080 1090 1100
EMESRRKKQL LRDLSGLQGM NGSVQAKSIQ VLPSHELVST RIAEHLGDSQ
1110 1120 1130 1140 1150
TLGRMLADYR ARGGRIQSKH LDPFVHSKDA SCTSGGKSGN KTESDEERGL
1160 1170 1180 1190 1200
IPSDVIWPTK VDCLNPANHQ RLCVLFSSSS AQSSNAPSAC VSPWIVTMEF
1210 1220 1230 1240 1250
YGKNDLTLGI FLERYCFRSS YQCPSMFCDT PMVHHIRRFV HGQGCVQIIL
1260 1270 1280 1290 1300
KELDSPVPGY QHTILTYSWC RICKQVTPVV ALSNESWSMS FAKYLELRFY
1310 1320 1330 1340 1350
GHQYTRRANA EPCGHSIHHD YHQYFSYNQM VASFSYSPIR LLEVCVPLPK
1360 1370 1380 1390 1400
IFIKRQAPLK VSLLQDLKDF FQKVSQVYLA VDERLASLKT DTFSKTREEK
1410 1420 1430 1440 1450
MEDIFAQKEM EEGEFKNWTE KMQARLMSSS VDTPQQLQSI FESLIAKKQS
1460 1470 1480 1490 1500
LCEVLQAWNS RLQDLFQQEK GRKRPSVPPS PGRLRQGEES KINAMDTSPR
1510 1520 1530 1540 1550
NISPGLHNGE KEDRFLTTLS SQSSTSSTHL QLPTPPEALA EQVVGGPTDL
1560 1570 1580 1590 1600
DSASGSEDVF DGHLLGSTDS QVKEKSTMKA IFANLLPGNS YNPIPFPFDP
1610 1620 1630 1640 1650
DKHYLMYEHE RVPIAVCEKE PSSIIAFALS CKEYRNALEE LSKATLRNSA
1660 1670 1680 1690 1700
EEGLPANSAL DNRPKSSSPI RLPEISGGQT NRTVEAEPQP TKKASGMLSF
1710 1720 1730 1740 1750
FRGTAGKSPD LSSQKRETLR GADSAYYQVG QAGKEGLESQ GLEPQDEVDG
1760 1770 1780 1790 1800
GDTQKKQLTN PHVELQFSDA NAKFYCRLYY AGEFHKMREV ILGSSEEEFI
1810 1820 1830 1840 1850
RSLSHSSPWQ ARGGKSGAAF YATEDDRFIL KQMPRLEVQS FLDFAPHYFN
1860 1870 1880 1890 1900
YITNAVQQKR PTALAKILGV YRIGYKNSQN NTEKKLDLLV MENLFYGRKM
1910 1920 1930 1940 1950
AQVFDLKGSL RNRNVKTDTG KESCDVVLLD ENLLKMVRDN PLYIRSHSKS
1960 1970 1980 1990 2000
VLRTSIHSDA HFLSSHLIID YSLLVGRDDT SNELVVGIID YIRTFTWDKK
2010 2020 2030 2040 2050
LEMVVKSTGI LGGQGKMPTV VSPELYRTRF CEAMDKYFLM VPDHWTGLDL

NC
Length:2,052
Mass (Da):232,080
Last modified:April 5, 2011 - v2
Checksum:iFA7B14B44651C100
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164079 Genomic DNA. No translation available.
RefSeqiNP_035216.2. NM_011086.2.
UniGeneiMm.38370.

Genome annotation databases

EnsembliENSMUST00000081154; ENSMUSP00000079926; ENSMUSG00000025949.
GeneIDi18711.
UCSCiuc007bhs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164079 Genomic DNA. No translation available.
RefSeqiNP_035216.2. NM_011086.2.
UniGeneiMm.38370.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079926.

Proteomic databases

MaxQBiD3Z5N5.
PaxDbiD3Z5N5.

Protocols and materials databases

DNASUi18711.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081154; ENSMUSP00000079926; ENSMUSG00000025949.
GeneIDi18711.
UCSCiuc007bhs.1. mouse.

Organism-specific databases

CTDi200576.
MGIiMGI:1335106. Pikfyve.

Phylogenomic databases

eggNOGiENOG410IMP3. Eukaryota.
KOG0230. Eukaryota.
COG0459. LUCA.
COG5253. LUCA.
GeneTreeiENSGT00840000129741.
HOGENOMiHOG000059273.

Miscellaneous databases

ChiTaRSiPikfyve. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiD3Z5N5.
ExpressionAtlasiD3Z5N5. baseline and differential.
GenevisibleiD3Z5N5. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.260.10. 2 hits.
3.30.40.10. 1 hit.
3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR002423. Cpn60/TCP-1.
IPR000591. DEP_dom.
IPR027409. GroEL-like_apical_dom.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR027410. TCP-1-like_intermed.
IPR011991. WHTH_DNA-bd_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
PF00610. DEP. 1 hit.
PF01363. FYVE. 1 hit.
PF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00064. FYVE. 1 hit.
SM00330. PIPKc. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52029. SSF52029. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS51455. PIPK. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z5N5_MOUSE
AccessioniPrimary (citable) accession number: D3Z5N5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.