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D3Z5M8

- D3Z5M8_MOUSE

UniProt

D3Z5M8 - D3Z5M8_MOUSE

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Protein
Submitted name:

Fibroblast growth factor receptor 2

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei514 – 5141Proton acceptorUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fibroblast growth factor-activated receptor activity Source: InterPro
  3. fibroblast growth factor binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. axonogenesis Source: MGI
  3. bone development Source: MGI
  4. bone mineralization Source: MGI
  5. bone morphogenesis Source: MGI
  6. branch elongation involved in salivary gland morphogenesis Source: MGI
  7. branching involved in labyrinthine layer morphogenesis Source: MGI
  8. branching involved in prostate gland morphogenesis Source: MGI
  9. branching involved in salivary gland morphogenesis Source: MGI
  10. branching morphogenesis of a nerve Source: MGI
  11. bud elongation involved in lung branching Source: MGI
  12. cell-cell signaling Source: MGI
  13. cell fate commitment Source: MGI
  14. coronal suture morphogenesis Source: MGI
  15. digestive tract development Source: MGI
  16. embryonic cranial skeleton morphogenesis Source: InterPro
  17. embryonic digestive tract morphogenesis Source: MGI
  18. embryonic organ development Source: MGI
  19. embryonic organ morphogenesis Source: MGI
  20. embryonic pattern specification Source: MGI
  21. endodermal digestive tract morphogenesis Source: MGI
  22. epidermis morphogenesis Source: MGI
  23. epithelial cell differentiation Source: MGI
  24. epithelial cell proliferation Source: MGI
  25. epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
  26. epithelial tube branching involved in lung morphogenesis Source: MGI
  27. fibroblast growth factor receptor signaling pathway Source: MGI
  28. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
  29. gland morphogenesis Source: MGI
  30. hair follicle morphogenesis Source: MGI
  31. inner ear morphogenesis Source: MGI
  32. in utero embryonic development Source: MGI
  33. lacrimal gland development Source: MGI
  34. lateral sprouting from an epithelium Source: MGI
  35. lens fiber cell development Source: MGI
  36. limb bud formation Source: MGI
  37. lung alveolus development Source: MGI
  38. lung-associated mesenchyme development Source: MGI
  39. lung development Source: MGI
  40. lung lobe morphogenesis Source: MGI
  41. mammary gland bud formation Source: MGI
  42. membranous septum morphogenesis Source: MGI
  43. mesenchymal cell differentiation Source: MGI
  44. mesenchymal cell differentiation involved in lung development Source: MGI
  45. mesenchymal cell proliferation involved in lung development Source: MGI
  46. midbrain development Source: MGI
  47. morphogenesis of embryonic epithelium Source: MGI
  48. multicellular organism growth Source: MGI
  49. negative regulation of cell proliferation Source: MGI
  50. negative regulation of mitosis Source: MGI
  51. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  52. neuromuscular junction development Source: MGI
  53. odontogenesis Source: MGI
  54. organ growth Source: MGI
  55. organ morphogenesis Source: MGI
  56. otic vesicle formation Source: MGI
  57. outflow tract septum morphogenesis Source: MGI
  58. positive regulation of canonical Wnt signaling pathway Source: MGI
  59. positive regulation of cardiac muscle cell proliferation Source: MGI
  60. positive regulation of cell division Source: MGI
  61. positive regulation of cell proliferation Source: MGI
  62. positive regulation of epithelial cell proliferation Source: MGI
  63. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  64. positive regulation of ERK1 and ERK2 cascade Source: MGI
  65. positive regulation of mesenchymal cell proliferation Source: MGI
  66. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  67. positive regulation of Wnt signaling pathway Source: MGI
  68. post-embryonic development Source: MGI
  69. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  70. prostate epithelial cord elongation Source: MGI
  71. prostate gland morphogenesis Source: MGI
  72. regulation of branching involved in prostate gland morphogenesis Source: MGI
  73. regulation of cell fate commitment Source: MGI
  74. regulation of cell proliferation Source: MGI
  75. regulation of epithelial cell proliferation Source: MGI
  76. regulation of ERK1 and ERK2 cascade Source: MGI
  77. regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  78. regulation of morphogenesis of a branching structure Source: MGI
  79. regulation of multicellular organism growth Source: MGI
  80. regulation of smoothened signaling pathway Source: MGI
  81. regulation of smooth muscle cell differentiation Source: MGI
  82. reproductive structure development Source: MGI
  83. squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGI
  84. synaptic vesicle transport Source: MGI
  85. ureteric bud development Source: MGI
  86. ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196455. Signaling by FGFR mutants.
REACT_196534. Signaling by FGFR2 amplification mutants.
REACT_196536. Activated point mutants of FGFR2.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206745. FGFR2c ligand binding and activation.
REACT_223937. FGFR2b ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Fibroblast growth factor receptor 2Imported
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiD3Z5M8.
ExpressionAtlasiD3Z5M8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD3Z5M8.
SMRiD3Z5M8. Positions 5-250, 355-689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118923.
HOGENOMiHOG000263410.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3Z5M8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEAY
60 70 80 90 100
VVAPGESLEL QCMLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR
110 120 130 140 150
DSGLYACTAA RTVDSETWYF MVNVTDAISS GDDEDDTDSS EDVVSENRSN
160 170 180 190 200
QRAPYWTNTE KMEKRLHAVP AANTVKFRCP AGGNPTPTMR WLKNGKEFKQ
210 220 230 240 250
EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CLVENEYGSI NHTYHLDVVA
260 270 280 290 300
PVREKEITAS PDYLEIAIYC IGVFLIACMV VTVIFCRMKT TTKKPDFSSQ
310 320 330 340 350
PAVHKLTKRI PLRRQVTVSA ESSSSMNSNT PLVRITTRLS STADTPMLAG
360 370 380 390 400
VSEYELPEDP KWEFPRDKLT LGKPLGEGCF GQVVMAEAVG IDKDKPKEAV
410 420 430 440 450
TVAVKMLKDD ATEKDLSDLV SEMEMMKMIG KHKNIINLLG ACTQDGPLYV
460 470 480 490 500
IVEYASKGNL REYLRARRPP GMEYSYDINR VPEEQMTFKD LVSCTYQLAR
510 520 530 540 550
GMEYLASQKC IHRDLAARNV LVTENNVMKI ADFGLARDIN NIDYYKKTTN
560 570 580 590 600
GRLPVKWMAP EALFDRVYTH QSDVWSFGVL MWEIFTLGGS PYPGIPVEEL
610 620 630 640 650
FKLLKEGHRM DKPTNCTNEL YMMMRDCWHA VPSQRPTFKQ LVEDLDRILT
660 670 680 690 700
LTTNEEYLDL TQPLEQYSPS YPDTRSSCSS GDDSVFSPDP MPYEPCLPQY

PHINGSVKT
Length:709
Mass (Da):79,966
Last modified:April 20, 2010 - v1
Checksum:i225BB8CB6E1BF612
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC087063 Genomic DNA. No translation available.
AC099609 Genomic DNA. No translation available.
AC099627 Genomic DNA. No translation available.
AC100735 Genomic DNA. No translation available.
AC101690 Genomic DNA. No translation available.
AC101762 Genomic DNA. No translation available.
AC105062 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC119806 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC126688 Genomic DNA. No translation available.
AC138624 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC156606 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC158314 Genomic DNA. No translation available.
AC159994 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
AC238818 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000120715; ENSMUSP00000113474; ENSMUSG00000030849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC087063 Genomic DNA. No translation available.
AC099609 Genomic DNA. No translation available.
AC099627 Genomic DNA. No translation available.
AC100735 Genomic DNA. No translation available.
AC101690 Genomic DNA. No translation available.
AC101762 Genomic DNA. No translation available.
AC105062 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC119806 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC126688 Genomic DNA. No translation available.
AC138624 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC156606 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC158314 Genomic DNA. No translation available.
AC159994 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
AC238818 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali D3Z5M8.
SMRi D3Z5M8. Positions 5-250, 355-689.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000120715 ; ENSMUSP00000113474 ; ENSMUSG00000030849 .

Organism-specific databases

MGIi MGI:95523. Fgfr2.

Phylogenomic databases

GeneTreei ENSGT00760000118923.
HOGENOMi HOG000263410.

Enzyme and pathway databases

Reactomei REACT_196455. Signaling by FGFR mutants.
REACT_196534. Signaling by FGFR2 amplification mutants.
REACT_196536. Activated point mutants of FGFR2.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206745. FGFR2c ligand binding and activation.
REACT_223937. FGFR2b ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

ChiTaRSi FGFR2. mouse.
NextBioi 35551272.
SOURCEi Search...

Gene expression databases

Bgeei D3Z5M8.
ExpressionAtlasi D3Z5M8. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
Pfami PF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000628. FGFR. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z5M8_MOUSE
AccessioniPrimary (citable) accession number: D3Z5M8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3