ID   D3Z596_MOUSE            Unreviewed;        79 AA.
AC   D3Z596;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Insulin II {ECO:0000313|Ensembl:ENSMUSP00000101550.2};
GN   Name=Ins2 {ECO:0000313|Ensembl:ENSMUSP00000101550.2,
GN   ECO:0000313|MGI:MGI:96573};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000101550.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000101550.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101550.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000101550.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101550.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; D3Z596; -.
DR   ProteomicsDB; 361016; -.
DR   Ensembl; ENSMUST00000105930.8; ENSMUSP00000101550.2; ENSMUSG00000000215.12.
DR   AGR; MGI:96573; -.
DR   MGI; MGI:96573; Ins2.
DR   VEuPathDB; HostDB:ENSMUSG00000000215; -.
DR   GeneTree; ENSGT00390000015440; -.
DR   HOGENOM; CLU_196933_0_0_1; -.
DR   ChiTaRS; Ins2; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000000215; Expressed in islet of Langerhans and 59 other cell types or tissues.
DR   ExpressionAtlas; D3Z596; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   Gene3D; 1.10.100.10; Insulin-like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   PANTHER; PTHR11454:SF33; INSULIN-2; 1.
DR   PANTHER; PTHR11454; INSULIN/INSULIN GROWTH FACTOR; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; Insulin-like; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|ProteomicsDB:D3Z596};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..79
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003052429"
FT   DOMAIN          28..79
FT                   /note="Insulin-like"
FT                   /evidence="ECO:0000259|SMART:SM00078"
FT   REGION          59..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   79 AA;  9014 MW;  E59CFFABE1EDDE6D CRC64;
     MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY TPMSRREVED
     PQGMQPLPPA GVKGRENLG
//