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Protein
Submitted name:

Insulin-2

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneSAAS annotation
Biological processCarbohydrate metabolism, Glucose metabolismSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-2Imported
Gene namesi
Name:Ins2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96573 Ins2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500305242925 – 79Sequence analysisAdd BLAST55

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiD3Z596

Expressioni

Gene expression databases

BgeeiENSMUSG00000000215
ExpressionAtlasiD3Z596 baseline and differential

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliD3Z596
SMRiD3Z596
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 79IlGFInterPro annotationAdd BLAST52

Sequence similaritiesi

Belongs to the insulin family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit

Sequencei

Sequence statusi: Complete.

D3Z596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY
60 70
TPMSRREVED PQGMQPLPPA GVKGRENLG
Length:79
Mass (Da):9,014
Last modified:April 20, 2010 - v1
Checksum:iE59CFFABE1EDDE6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012382 Genomic DNA No translation available.
AC013548 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000105930; ENSMUSP00000101550; ENSMUSG00000000215

Similar proteinsi

Entry informationi

Entry nameiD3Z596_MOUSE
AccessioniPrimary (citable) accession number: D3Z596
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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