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D3Z4R4

- D3Z4R4_MOUSE

UniProt

D3Z4R4 - D3Z4R4_MOUSE

Protein
Submitted name:

NK6 transcription factor related, locus 2 (Drosophila)

Gene

Nkx6-2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: MGI
    3. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. central nervous system myelination Source: MGI
    3. endocrine pancreas development Source: MGI
    4. negative regulation of cell fate commitment Source: MGI
    5. negative regulation of glial cell differentiation Source: MGI
    6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    7. neuromuscular process controlling balance Source: MGI
    8. oligodendrocyte differentiation Source: MGI
    9. positive regulation of cell fate commitment Source: MGI
    10. positive regulation of glial cell differentiation Source: MGI
    11. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: MGI
    12. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: MGI

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NK6 transcription factor related, locus 2 (Drosophila)Imported
    Submitted name:
    Protein Nkx6-2Imported
    Gene namesi
    Name:Nkx6-2Imported
    ORF Names:mCG_21615Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1352738. Nkx6-2.

    Subcellular locationi

    Nucleus UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains homeobox DNA-binding domain.SAAS annotation

    Keywords - Domaini

    HomeoboxUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117350.
    HOGENOMiHOG000060127.
    KOiK09350.
    OMAiGRAPIFW.
    OrthoDBiEOG7Z95QB.
    TreeFamiTF327063.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3Z4R4-1 [UniParc]FASTAAdd to Basket

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    MDANRPGAFV LSSAPLAALH NMAEMKTSLF PYALQGPAGF KTPALGSLGA    50
    QLPLGTPHGI SDILGRPVGA AGGGLLGSLP RLNGLASSAG VYFGPAAAVA 100
    RGYPKPLAEL PGRPPIFWPG VVQGSPWRDP RLAGSAQAGG VLDKDGKKKH 150
    SRPTFSGQQI FALEKTFEQT KYLAGPERAR LAYSLGMTES QVKVWFQNRR 200
    TKWRKRHAAE MASAKKKQDS DAEKLKVGGS DAEDDDEYNR PLDPNSDDEK 250
    ITRLLKKHKP SNLALVSPCG GSAGDAL 277
    Length:277
    Mass (Da):29,362
    Last modified:April 20, 2010 - v1
    Checksum:iD4FA6DF6FFD66167
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC112670 Genomic DNA. No translation available.
    CH466531 Genomic DNA. Translation: EDL17860.1.
    RefSeqiNP_899071.2. NM_183248.3.
    UniGeneiMm.28308.
    Mm.476889.

    Genome annotation databases

    EnsembliENSMUST00000097974; ENSMUSP00000095588; ENSMUSG00000041309.
    ENSMUST00000106095; ENSMUSP00000101701; ENSMUSG00000041309.
    GeneIDi14912.
    KEGGimmu:14912.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC112670 Genomic DNA. No translation available.
    CH466531 Genomic DNA. Translation: EDL17860.1 .
    RefSeqi NP_899071.2. NM_183248.3.
    UniGenei Mm.28308.
    Mm.476889.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 14912.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097974 ; ENSMUSP00000095588 ; ENSMUSG00000041309 .
    ENSMUST00000106095 ; ENSMUSP00000101701 ; ENSMUSG00000041309 .
    GeneIDi 14912.
    KEGGi mmu:14912.

    Organism-specific databases

    CTDi 84504.
    MGIi MGI:1352738. Nkx6-2.

    Phylogenomic databases

    GeneTreei ENSGT00750000117350.
    HOGENOMi HOG000060127.
    KOi K09350.
    OMAi GRAPIFW.
    OrthoDBi EOG7Z95QB.
    TreeFami TF327063.

    Miscellaneous databases

    NextBioi 287201.
    PROi D3Z4R4.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiD3Z4R4_MOUSE
    AccessioniPrimary (citable) accession number: D3Z4R4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3