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D3Z4R4

- D3Z4R4_MOUSE

UniProt

D3Z4R4 - D3Z4R4_MOUSE

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Protein
Submitted name:

NK6 transcription factor related, locus 2 (Drosophila)

Gene

Nkx6-2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: MGI
  2. central nervous system myelination Source: MGI
  3. endocrine pancreas development Source: MGI
  4. negative regulation of cell fate commitment Source: MGI
  5. negative regulation of glial cell differentiation Source: MGI
  6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  7. neuromuscular process controlling balance Source: MGI
  8. oligodendrocyte differentiation Source: MGI
  9. positive regulation of cell fate commitment Source: MGI
  10. positive regulation of glial cell differentiation Source: MGI
  11. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: MGI
  12. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
NK6 transcription factor related, locus 2 (Drosophila)Imported
Submitted name:
Protein Nkx6-2Imported
Gene namesi
Name:Nkx6-2Imported
ORF Names:mCG_21615Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352738. Nkx6-2.

Subcellular locationi

Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains homeobox DNA-binding domain.SAAS annotation

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118779.
HOGENOMiHOG000060127.
KOiK09350.
OMAiGRAPIFW.
OrthoDBiEOG7Z95QB.
TreeFamiTF327063.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Z4R4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDANRPGAFV LSSAPLAALH NMAEMKTSLF PYALQGPAGF KTPALGSLGA
60 70 80 90 100
QLPLGTPHGI SDILGRPVGA AGGGLLGSLP RLNGLASSAG VYFGPAAAVA
110 120 130 140 150
RGYPKPLAEL PGRPPIFWPG VVQGSPWRDP RLAGSAQAGG VLDKDGKKKH
160 170 180 190 200
SRPTFSGQQI FALEKTFEQT KYLAGPERAR LAYSLGMTES QVKVWFQNRR
210 220 230 240 250
TKWRKRHAAE MASAKKKQDS DAEKLKVGGS DAEDDDEYNR PLDPNSDDEK
260 270
ITRLLKKHKP SNLALVSPCG GSAGDAL
Length:277
Mass (Da):29,362
Last modified:April 20, 2010 - v1
Checksum:iD4FA6DF6FFD66167
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC112670 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL17860.1.
RefSeqiNP_899071.2. NM_183248.3.
UniGeneiMm.28308.
Mm.476889.

Genome annotation databases

EnsembliENSMUST00000097974; ENSMUSP00000095588; ENSMUSG00000041309.
ENSMUST00000106095; ENSMUSP00000101701; ENSMUSG00000041309.
GeneIDi14912.
KEGGimmu:14912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC112670 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL17860.1 .
RefSeqi NP_899071.2. NM_183248.3.
UniGenei Mm.28308.
Mm.476889.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 14912.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097974 ; ENSMUSP00000095588 ; ENSMUSG00000041309 .
ENSMUST00000106095 ; ENSMUSP00000101701 ; ENSMUSG00000041309 .
GeneIDi 14912.
KEGGi mmu:14912.

Organism-specific databases

CTDi 84504.
MGIi MGI:1352738. Nkx6-2.

Phylogenomic databases

GeneTreei ENSGT00760000118779.
HOGENOMi HOG000060127.
KOi K09350.
OMAi GRAPIFW.
OrthoDBi EOG7Z95QB.
TreeFami TF327063.

Miscellaneous databases

NextBioi 287201.
PROi D3Z4R4.
SOURCEi Search...

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z4R4_MOUSE
AccessioniPrimary (citable) accession number: D3Z4R4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3