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D3Z4R4 (D3Z4R4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Nkx6-2 Ensembl ENSMUSP00000095588 Ensembl ENSMUSP00000101701 EMBL EDL17860.1 MGI 1352738
ORF Names:mCG_21615 EMBL EDL17860.1
OrganismMus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000101701
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Nucleus By similarity SAAS SAAS020479 RuleBase RU000682.

Sequence similarities

Contains homeobox DNA-binding domain. SAAS SAAS020479

Ontologies

Keywords
   Cellular componentNucleus SAAS SAAS020479 RuleBase RU000682
   DomainHomeobox SAAS SAAS020479 RuleBase RU000682
   LigandDNA-binding SAAS SAAS020479 RuleBase RU000682
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from genetic interaction PubMed 15944193. Source: MGI

central nervous system myelination

Inferred from mutant phenotype PubMed 15601927. Source: MGI

endocrine pancreas development

Inferred from genetic interaction PubMed 15944193. Source: MGI

negative regulation of cell fate commitment

Inferred from mutant phenotype PubMed 11567614. Source: MGI

negative regulation of glial cell differentiation

Inferred from genetic interaction PubMed 15629702. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 8096811. Source: MGI

neuromuscular process controlling balance

Inferred from mutant phenotype PubMed 15601927. Source: MGI

oligodendrocyte differentiation

Inferred from genetic interaction PubMed 15629701. Source: MGI

positive regulation of cell fate commitment

Inferred from mutant phenotype PubMed 11567614. Source: MGI

positive regulation of glial cell differentiation

Inferred from genetic interaction PubMed 15629702. Source: MGI

regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification

Inferred from genetic interaction PubMed 11567614. Source: MGI

regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification

Inferred from mutant phenotype PubMed 11567614. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 11567614. Source: MGI

   Molecular_functionsequence-specific DNA binding

Inferred from direct assay PubMed 8096811. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 8096811. Source: MGI

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
D3Z4R4 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: D4FA6DF6FFD66167

FASTA27729,362
        10         20         30         40         50         60 
MDANRPGAFV LSSAPLAALH NMAEMKTSLF PYALQGPAGF KTPALGSLGA QLPLGTPHGI 

        70         80         90        100        110        120 
SDILGRPVGA AGGGLLGSLP RLNGLASSAG VYFGPAAAVA RGYPKPLAEL PGRPPIFWPG 

       130        140        150        160        170        180 
VVQGSPWRDP RLAGSAQAGG VLDKDGKKKH SRPTFSGQQI FALEKTFEQT KYLAGPERAR 

       190        200        210        220        230        240 
LAYSLGMTES QVKVWFQNRR TKWRKRHAAE MASAKKKQDS DAEKLKVGGS DAEDDDEYNR 

       250        260        270 
PLDPNSDDEK ITRLLKKHKP SNLALVSPCG GSAGDAL 

« Hide

References

« Hide 'large scale' references
[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL17860.1.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL17860.1.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000095588 Ensembl ENSMUSP00000101701.
[4]Ensembl
Submitted (MAY-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000101701.
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000095588.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC112670 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL17860.1.
RefSeqNP_899071.2. NM_183248.3.
UniGeneMm.28308.
Mm.476889.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

DNASU14912.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000097974; ENSMUSP00000095588; ENSMUSG00000041309.
ENSMUST00000106095; ENSMUSP00000101701; ENSMUSG00000041309.
GeneID14912.
KEGGmmu:14912.

Organism-specific databases

CTD84504.
MGIMGI:1352738. Nkx6-2.

Phylogenomic databases

GeneTreeENSGT00750000117350.
HOGENOMHOG000060127.
KOK09350.
OMAGRAPIFW.
OrthoDBEOG7Z95QB.
TreeFamTF327063.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287201.
PROD3Z4R4.
SOURCESearch...

Entry information

Entry nameD3Z4R4_MOUSE
AccessionPrimary (citable) accession number: D3Z4R4
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)