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Protein
Submitted name:

NK6 homeobox 2

Gene

Nkx6-2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi148 – 207HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • cell differentiation Source: MGI
  • central nervous system myelination Source: MGI
  • endocrine pancreas development Source: MGI
  • negative regulation of cell fate commitment Source: MGI
  • negative regulation of glial cell differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • oligodendrocyte differentiation Source: MGI
  • positive regulation of cell fate commitment Source: MGI
  • positive regulation of glial cell differentiation Source: MGI
  • regulation of myelination Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: MGI
  • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: MGI

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
NK6 homeobox 2Imported
Submitted name:
NK6 transcription factor related, locus 2 (Drosophila)Imported
Gene namesi
Name:Nkx6-2Imported
ORF Names:mCG_21615Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1352738 Nkx6-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000041309

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095588

Structurei

3D structure databases

SMRiD3Z4R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 206HomeoboxInterPro annotationAdd BLAST61

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0847 Eukaryota
ENOG410XT1X LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000060127
KOiK09350
OMAiGRAPIFW
OrthoDBiEOG091G142D
TreeFamiTF327063

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

D3Z4R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDANRPGAFV LSSAPLAALH NMAEMKTSLF PYALQGPAGF KTPALGSLGA
60 70 80 90 100
QLPLGTPHGI SDILGRPVGA AGGGLLGSLP RLNGLASSAG VYFGPAAAVA
110 120 130 140 150
RGYPKPLAEL PGRPPIFWPG VVQGSPWRDP RLAGSAQAGG VLDKDGKKKH
160 170 180 190 200
SRPTFSGQQI FALEKTFEQT KYLAGPERAR LAYSLGMTES QVKVWFQNRR
210 220 230 240 250
TKWRKRHAAE MASAKKKQDS DAEKLKVGGS DAEDDDEYNR PLDPNSDDEK
260 270
ITRLLKKHKP SNLALVSPCG GSAGDAL
Length:277
Mass (Da):29,362
Last modified:April 20, 2010 - v1
Checksum:iD4FA6DF6FFD66167
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112670 Genomic DNA No translation available.
CH466531 Genomic DNA Translation: EDL17860.1
RefSeqiNP_899071.2, NM_183248.3
UniGeneiMm.28308
Mm.476889

Genome annotation databases

EnsembliENSMUST00000097974; ENSMUSP00000095588; ENSMUSG00000041309
ENSMUST00000106095; ENSMUSP00000101701; ENSMUSG00000041309
GeneIDi14912
KEGGimmu:14912

Similar proteinsi

Entry informationi

Entry nameiD3Z4R4_MOUSE
AccessioniPrimary (citable) accession number: D3Z4R4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported