ID D3Z3V1_MOUSE Unreviewed; 459 AA. AC D3Z3V1; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 27-MAR-2024, entry version 72. DE SubName: Full=Solute carrier family 12 (potassium/chloride transporters), member 8 {ECO:0000313|Ensembl:ENSMUSP00000113901.2}; GN Name=Slc12a8 {ECO:0000313|Ensembl:ENSMUSP00000113901.2, GN ECO:0000313|MGI:MGI:2443672}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000113901.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000113901.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000113901.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000113901.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000113901.2}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the SLC12A transporter family. CC {ECO:0000256|ARBA:ARBA00010593}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; D3Z3V1; -. DR ProteomicsDB; 326764; -. DR Antibodypedia; 33008; 50 antibodies from 17 providers. DR Ensembl; ENSMUST00000122314.8; ENSMUSP00000113901.2; ENSMUSG00000035506.17. DR AGR; MGI:2443672; -. DR MGI; MGI:2443672; Slc12a8. DR VEuPathDB; HostDB:ENSMUSG00000035506; -. DR GeneTree; ENSGT00940000160130; -. DR OMA; IMFIIQW; -. DR ChiTaRS; Slc12a8; mouse. DR Proteomes; UP000000589; Chromosome 16. DR Bgee; ENSMUSG00000035506; Expressed in gastrula and 94 other cell types or tissues. DR ExpressionAtlas; D3Z3V1; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro. DR GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:UniProt. DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1. DR InterPro; IPR004841; AA-permease/SLC12A_dom. DR InterPro; IPR004842; SLC12A_fam. DR PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1. DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1. DR Pfam; PF00324; AA_permease; 1. PE 1: Evidence at protein level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|ProteomicsDB:D3Z3V1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 20..39 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 60..82 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 114..140 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 332..353 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 2..149 FT /note="Amino acid permease/ SLC12A" FT /evidence="ECO:0000259|Pfam:PF00324" FT REGION 226..266 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 459 AA; 50785 MW; E5BD3E2D1248ACED CRC64; MAGFNMGGDL RDPADSVPLG SLAAVGVSWF LYIIFAFLLG AVCTREALRS DFLIAEKVSL VGFLFLLGLY ISSLASCMGG LYGAPRILQC IAQDKVIPAL AFLANGKGPN KTPVAAICLT SLVTMAFVLV GQVNVLAPVV TINFMLTYIM VDYSYFALSM AHCGLAPSPE PVPRQGPDTL HCSEHLLQDR APSYGSDVPA RSLSEGTLLE FTKDMDQFLQ PIEELESRQL GSREGNNPKN QKRKGKKGAK QTLQDSFLLD PGSPLSFPTR TSERLSVAFC GEQESYQKQQ TSRSESHDHL VPDLRNQPRV NREDFFLKCR LQEQEIQRRP SVFYACMCNP WVSLLGALAS LLIMFVIQWL YTLASMGVAA LVYFYIGQAS PGLYLGSASN FSFFQWMKSF LVPSCRSLRS AQEQIILAPS PAKVDMAMTQ LTQDNADFAT RDRYHHSSFL SREQLMPPY //