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Protein

V-type proton ATPase proteolipid subunit

Gene

Atp6v0c

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase proteolipid subunitUniRule annotation
Gene namesi
Name:Atp6v0cImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88116 Atp6v0c

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei62 – 83HelicalUniRule annotationAdd BLAST22
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, VacuoleUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiD3Z3B2
PeptideAtlasiD3Z3B2
PRIDEiD3Z3B2

Expressioni

Gene expression databases

BgeeiENSMUSG00000024121
ExpressionAtlasiD3Z3B2 baseline and differential

Structurei

3D structure databases

SMRiD3Z3B2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 82ATP-synt_CInterPro annotationAdd BLAST50

Sequence similaritiesi

Belongs to the V-ATPase proteolipid subunit family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0232 Eukaryota
COG0636 LUCA
GeneTreeiENSGT00550000074873
HOGENOMiHOG000056520

Family and domain databases

InterProiView protein in InterPro
IPR002379 ATPase_proteolipid_c-like_dom
IPR000245 ATPase_proteolipid_csu
IPR011555 ATPase_proteolipid_su_C_euk
IPR035921 F/V-ATP_Csub_sf
PfamiView protein in Pfam
PF00137 ATP-synt_C, 1 hit
PRINTSiPR00122 VACATPASE
SUPFAMiSSF81333 SSF81333, 1 hit
TIGRFAMsiTIGR01100 V_ATP_synt_C, 1 hit

Sequencei

Sequence statusi: Fragment.

D3Z3B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATAPPRGT DDPKTRRVRE DDCVEPRASE DPAMGAAYGT AKSGTGIAAM
60 70 80 90 100
SVMRPELIMK SIIPVVMAGI IAIYGLVVAV LIANSLTDGI TLYRSFLQLG
110
AGLSVGLSGL AAGFAI
Length:116
Mass (Da):11,896
Last modified:April 20, 2010 - v1
Checksum:i6EB11517BA249AA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei116Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010502 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000150647; ENSMUSP00000122843; ENSMUSG00000024121

Entry informationi

Entry nameiD3Z3B2_MOUSE
AccessioniPrimary (citable) accession number: D3Z3B2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health