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D3Z357

- D3Z357_MOUSE

UniProt

D3Z357 - D3Z357_MOUSE

Protein
Submitted name:

Histone-lysine N-methyltransferase NSD3

Gene

Whsc1l1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: Ensembl
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Histone-lysine N-methyltransferase NSD3Imported
    Gene namesi
    Name:Whsc1l1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2142581. Whsc1l1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains 1 post-SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114921.
    HOGENOMiHOG000230893.
    KOiK11425.
    OMAiMEKDIHK.

    Family and domain databases

    Gene3Di3.30.40.10. 3 hits.
    InterProiIPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 3 hits.
    PROSITEiPS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3Z357-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNHSDI VEDGGPTPFE     50
    ATLQQGFQYP PTTEDLPPLT NGYPPSISLY ETQTKYPPYN QYPNGSANGF 100
    GAVRNFSPTD YYHSEIPNTR PHEILEKPSP PQPPPLPPPP PPPPPPPSVP 150
    QTVIPKKTGS PEIKLKITKT IQNGRELFES SLCGDLLNEV QASEHTKSKH 200
    ESRKEKRKKS NRHESSRSEE RRSHKIPKLE PEGQNRPNER VDTAPEKPRE 250
    EPVLKEAIPV QPILSSVPTT ETSTGVKFQV GDLVWSKVGT YPWWPCMVSS 300
    DPQLEVHSKI NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHEQYEELL 350
    AEAAKQASNH SEKQKIRKPR PQRERAQWDI GIAHAEKALK MTREERVEQY 400
    TFIYIDKQPE EASSQAKKNV TSKTEVKKPR RPRSVLNSQP EQTNAGEVAS 450
    SQSSTDLRRQ SQRRHTSLEE EEPPPVKIAW KTAAARKSLP ASITMHKGSL 500
    DLQKCNMSPV VKIEQVFALQ NATGDGKFID QFVYSTKGIG NKTEISVRGQ 550
    DRLIISSPSQ RSEKPAQSAS SPEATSGSAG PVEKKQQRRS IRTRSESEKS 600
    AEVVPKKKIK KEQVETAPQA SLKTGLQKGA SEISDSCKPL KKRSRASTDV 650
    ETASCTYRDT SDSDSRGLSD GQVGFGKQVD SPSATADADA SDAQSVDSSL 700
    SRRGVGTSKK DTVCQVCEKA GDCLVACEGE CCRHFHVECL GLTAVPEGHF 750
    TCEECETGQH PCFSCKVSGK DVKRCSVSVC GKFYHEACVR KFPTAIFESK 800
    GFRCPQHCCS SCSMEKDIHK ASKGRMMRCL RCPVAYHVGD ACVAAGSVSV 850
    SSHILICSNH SKRSSQSAAI NVGFCFVCAR GLIVQDHSDP MFSSYAYKSH 900
    YLLSESNRAE LMKLPMIPSS SASKKRCEKG GRLLCCESCP ASFHPECLSI 950
    DMPEGCWNCN DCKAGKKLHY KQIVWVKLGN YRWWPAEICS PRSVPLNIQG 1000
    LKHDLGDFPV FFFGSHDYYW VHQGRVFPYV EGDKHFAEGQ TSINKTFKKA 1050
    LEEAAKRFQE LKAQRESKEA LEMERTSRKP PPYKHIKANK VIGKVQVQVA 1100
    DLSEIPRCNC KPGDENPCGL ESQCLNRMSQ YECHPQVCPA GDRCQNQCFT 1150
    KRLYPDAEVI KTERRGWGLR TKRSIKKGEF VNEYVGELID EEECRLRIKR 1200
    AHENSVTNFY MLTVTKDRII DAGPKGNYSR FMNHSCNPNC ETQKWTVNGD 1250
    VRVGLFALCD IPAGMELTFN YNLDCLGNGR TVCHCGADNC SGFLGVRPKS 1300
    ACTSAVDEKT KNAKLKKRRK VKAEAKPIHE DYCFQCGDGG ELVMCDKKDC 1350
    PKAYHLLCLN LTQPPHGKWE CPWHRCDECG SVAVSFCEFC PHSFCKAHGK 1400
    GALVPSALEG RLCCSSHDPA SPVSPEYWSK IRCKWESQDS GEEVKE 1446
    Length:1,446
    Mass (Da):161,649
    Last modified:April 20, 2010 - v1
    Checksum:i7AD4541DBCC619C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC156990 Genomic DNA. No translation available.
    RefSeqiNP_001074738.1. NM_001081269.1.
    XP_006509163.1. XM_006509100.1.
    XP_006509164.1. XM_006509101.1.
    UniGeneiMm.217337.

    Genome annotation databases

    EnsembliENSMUST00000084026; ENSMUSP00000081040; ENSMUSG00000054823.
    ENSMUST00000142395; ENSMUSP00000117778; ENSMUSG00000054823.
    GeneIDi234135.
    KEGGimmu:234135.
    UCSCiuc009lgn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC156990 Genomic DNA. No translation available.
    RefSeqi NP_001074738.1. NM_001081269.1.
    XP_006509163.1. XM_006509100.1.
    XP_006509164.1. XM_006509101.1.
    UniGenei Mm.217337.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 234135.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084026 ; ENSMUSP00000081040 ; ENSMUSG00000054823 .
    ENSMUST00000142395 ; ENSMUSP00000117778 ; ENSMUSG00000054823 .
    GeneIDi 234135.
    KEGGi mmu:234135.
    UCSCi uc009lgn.1. mouse.

    Organism-specific databases

    CTDi 54904.
    MGIi MGI:2142581. Whsc1l1.

    Phylogenomic databases

    GeneTreei ENSGT00740000114921.
    HOGENOMi HOG000230893.
    KOi K11425.
    OMAi MEKDIHK.

    Miscellaneous databases

    ChiTaRSi WHSC1L1. mouse.
    NextBioi 382034.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 3.30.40.10. 3 hits.
    InterProi IPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 3 hits.
    PROSITEi PS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiD3Z357_MOUSE
    AccessioniPrimary (citable) accession number: D3Z357
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3