Histone-lysine N-methyltransferase NSD3

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D3Z357 (D3Z357_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 33. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Histone-lysine N-methyltransferase NSD3 Ensembl ENSMUSP00000081040 Ensembl ENSMUSP00000117778

Gene names

Name:

Whsc1l1 Ensembl ENSMUSP00000081040 Ensembl ENSMUSP00000117778 MGI 2142581

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000081040 Ensembl ENSMUSP00000117778

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1446 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214

Sequence similarities

Contains 1 SET domain. SAAS SAAS001214 RuleBase RU004538

Contains 1 post-SET domain. SAAS SAAS001214 RuleBase RU004541

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000081040 Ensembl ENSMUSP00000117778

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS003616
Domain	Zinc-finger SAAS SAAS001965
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase SAAS SAAS001214 RuleBase RU004541 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

D3Z357 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 7AD4541DBCC619C6
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FASTA

1,446

161,649

        10         20         30         40         50         60 
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNHSDI VEDGGPTPFE ATLQQGFQYP 

        70         80         90        100        110        120 
PTTEDLPPLT NGYPPSISLY ETQTKYPPYN QYPNGSANGF GAVRNFSPTD YYHSEIPNTR 

       130        140        150        160        170        180 
PHEILEKPSP PQPPPLPPPP PPPPPPPSVP QTVIPKKTGS PEIKLKITKT IQNGRELFES 

       190        200        210        220        230        240 
SLCGDLLNEV QASEHTKSKH ESRKEKRKKS NRHESSRSEE RRSHKIPKLE PEGQNRPNER 

       250        260        270        280        290        300 
VDTAPEKPRE EPVLKEAIPV QPILSSVPTT ETSTGVKFQV GDLVWSKVGT YPWWPCMVSS 

       310        320        330        340        350        360 
DPQLEVHSKI NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHEQYEELL AEAAKQASNH 

       370        380        390        400        410        420 
SEKQKIRKPR PQRERAQWDI GIAHAEKALK MTREERVEQY TFIYIDKQPE EASSQAKKNV 

       430        440        450        460        470        480 
TSKTEVKKPR RPRSVLNSQP EQTNAGEVAS SQSSTDLRRQ SQRRHTSLEE EEPPPVKIAW 

       490        500        510        520        530        540 
KTAAARKSLP ASITMHKGSL DLQKCNMSPV VKIEQVFALQ NATGDGKFID QFVYSTKGIG 

       550        560        570        580        590        600 
NKTEISVRGQ DRLIISSPSQ RSEKPAQSAS SPEATSGSAG PVEKKQQRRS IRTRSESEKS 

       610        620        630        640        650        660 
AEVVPKKKIK KEQVETAPQA SLKTGLQKGA SEISDSCKPL KKRSRASTDV ETASCTYRDT 

       670        680        690        700        710        720 
SDSDSRGLSD GQVGFGKQVD SPSATADADA SDAQSVDSSL SRRGVGTSKK DTVCQVCEKA 

       730        740        750        760        770        780 
GDCLVACEGE CCRHFHVECL GLTAVPEGHF TCEECETGQH PCFSCKVSGK DVKRCSVSVC 

       790        800        810        820        830        840 
GKFYHEACVR KFPTAIFESK GFRCPQHCCS SCSMEKDIHK ASKGRMMRCL RCPVAYHVGD 

       850        860        870        880        890        900 
ACVAAGSVSV SSHILICSNH SKRSSQSAAI NVGFCFVCAR GLIVQDHSDP MFSSYAYKSH 

       910        920        930        940        950        960 
YLLSESNRAE LMKLPMIPSS SASKKRCEKG GRLLCCESCP ASFHPECLSI DMPEGCWNCN 

       970        980        990       1000       1010       1020 
DCKAGKKLHY KQIVWVKLGN YRWWPAEICS PRSVPLNIQG LKHDLGDFPV FFFGSHDYYW 

      1030       1040       1050       1060       1070       1080 
VHQGRVFPYV EGDKHFAEGQ TSINKTFKKA LEEAAKRFQE LKAQRESKEA LEMERTSRKP 

      1090       1100       1110       1120       1130       1140 
PPYKHIKANK VIGKVQVQVA DLSEIPRCNC KPGDENPCGL ESQCLNRMSQ YECHPQVCPA 

      1150       1160       1170       1180       1190       1200 
GDRCQNQCFT KRLYPDAEVI KTERRGWGLR TKRSIKKGEF VNEYVGELID EEECRLRIKR 

      1210       1220       1230       1240       1250       1260 
AHENSVTNFY MLTVTKDRII DAGPKGNYSR FMNHSCNPNC ETQKWTVNGD VRVGLFALCD 

      1270       1280       1290       1300       1310       1320 
IPAGMELTFN YNLDCLGNGR TVCHCGADNC SGFLGVRPKS ACTSAVDEKT KNAKLKKRRK 

      1330       1340       1350       1360       1370       1380 
VKAEAKPIHE DYCFQCGDGG ELVMCDKKDC PKAYHLLCLN LTQPPHGKWE CPWHRCDECG 

      1390       1400       1410       1420       1430       1440 
SVAVSFCEFC PHSFCKAHGK GALVPSALEG RLCCSSHDPA SPVSPEYWSK IRCKWESQDS 


GEEVKE

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000081040 Ensembl ENSMUSP00000117778.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000081040.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000117778.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC156990 Genomic DNA. No translation available.
IPI	IPI00663331.
RefSeq	NP_001074738.1. NM_001081269.1.
UniGene	Mm.217337.
3D structure databases
SMR	D3Z357. Positions 275-342, 709-862, 929-963, 967-1295, 1328-1422.
ModBase	Search...
Protocols and materials databases
DNASU	234135.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000084026; ENSMUSP00000081040; ENSMUSG00000054823. ENSMUST00000142395; ENSMUSP00000117778; ENSMUSG00000054823.
GeneID	234135.
KEGG	mmu:234135.
UCSC	uc009lgn.1. mouse.
Organism-specific databases
CTD	54904.
MGI	MGI:2142581. Whsc1l1.
Phylogenomic databases
GeneTree	ENSGT00700000104009.
HOGENOM	HOG000230893.
KO	K11425.
OMA	MEKDIHK.
Family and domain databases
Gene3D	3.30.40.10. 3 hits.
InterPro	IPR006560. AWS. IPR003616. Post-SET_dom. IPR000313. PWWP. IPR001214. SET_dom. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF00855. PWWP. 2 hits. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00249. PHD. 5 hits. SM00508. PostSET. 1 hit. SM00293. PWWP. 2 hits. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 3 hits.
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50812. PWWP. 2 hits. PS50280. SET. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WHSC1L1. mouse.
NextBio	382034.
SOURCE	Search...

Entry information

Entry name

D3Z357_MOUSE

Accession

Primary (citable) accession number: D3Z357

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information