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Protein

Histone-lysine N-methyltransferase

Gene

Whsc1l1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: MGI
  2. histone methyltransferase activity (H3-K27 specific) Source: MGI
  3. histone methyltransferase activity (H3-K4 specific) Source: MGI
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone H3-K27 methylation Source: GOC
  2. histone H3-K4 methylation Source: GOC
  3. histone lysine methylation Source: MGI
  4. histone methylation Source: MGI
  5. negative regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Name:Whsc1l1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2142581. Whsc1l1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD3Z357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121845.
HOGENOMiHOG000230893.
KOiK11425.
OMAiMEKDIHK.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 3 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Z357-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNHSDI VEDGGPTPFE
60 70 80 90 100
ATLQQGFQYP PTTEDLPPLT NGYPPSISLY ETQTKYPPYN QYPNGSANGF
110 120 130 140 150
GAVRNFSPTD YYHSEIPNTR PHEILEKPSP PQPPPLPPPP PPPPPPPSVP
160 170 180 190 200
QTVIPKKTGS PEIKLKITKT IQNGRELFES SLCGDLLNEV QASEHTKSKH
210 220 230 240 250
ESRKEKRKKS NRHESSRSEE RRSHKIPKLE PEGQNRPNER VDTAPEKPRE
260 270 280 290 300
EPVLKEAIPV QPILSSVPTT ETSTGVKFQV GDLVWSKVGT YPWWPCMVSS
310 320 330 340 350
DPQLEVHSKI NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHEQYEELL
360 370 380 390 400
AEAAKQASNH SEKQKIRKPR PQRERAQWDI GIAHAEKALK MTREERVEQY
410 420 430 440 450
TFIYIDKQPE EASSQAKKNV TSKTEVKKPR RPRSVLNSQP EQTNAGEVAS
460 470 480 490 500
SQSSTDLRRQ SQRRHTSLEE EEPPPVKIAW KTAAARKSLP ASITMHKGSL
510 520 530 540 550
DLQKCNMSPV VKIEQVFALQ NATGDGKFID QFVYSTKGIG NKTEISVRGQ
560 570 580 590 600
DRLIISSPSQ RSEKPAQSAS SPEATSGSAG PVEKKQQRRS IRTRSESEKS
610 620 630 640 650
AEVVPKKKIK KEQVETAPQA SLKTGLQKGA SEISDSCKPL KKRSRASTDV
660 670 680 690 700
ETASCTYRDT SDSDSRGLSD GQVGFGKQVD SPSATADADA SDAQSVDSSL
710 720 730 740 750
SRRGVGTSKK DTVCQVCEKA GDCLVACEGE CCRHFHVECL GLTAVPEGHF
760 770 780 790 800
TCEECETGQH PCFSCKVSGK DVKRCSVSVC GKFYHEACVR KFPTAIFESK
810 820 830 840 850
GFRCPQHCCS SCSMEKDIHK ASKGRMMRCL RCPVAYHVGD ACVAAGSVSV
860 870 880 890 900
SSHILICSNH SKRSSQSAAI NVGFCFVCAR GLIVQDHSDP MFSSYAYKSH
910 920 930 940 950
YLLSESNRAE LMKLPMIPSS SASKKRCEKG GRLLCCESCP ASFHPECLSI
960 970 980 990 1000
DMPEGCWNCN DCKAGKKLHY KQIVWVKLGN YRWWPAEICS PRSVPLNIQG
1010 1020 1030 1040 1050
LKHDLGDFPV FFFGSHDYYW VHQGRVFPYV EGDKHFAEGQ TSINKTFKKA
1060 1070 1080 1090 1100
LEEAAKRFQE LKAQRESKEA LEMERTSRKP PPYKHIKANK VIGKVQVQVA
1110 1120 1130 1140 1150
DLSEIPRCNC KPGDENPCGL ESQCLNRMSQ YECHPQVCPA GDRCQNQCFT
1160 1170 1180 1190 1200
KRLYPDAEVI KTERRGWGLR TKRSIKKGEF VNEYVGELID EEECRLRIKR
1210 1220 1230 1240 1250
AHENSVTNFY MLTVTKDRII DAGPKGNYSR FMNHSCNPNC ETQKWTVNGD
1260 1270 1280 1290 1300
VRVGLFALCD IPAGMELTFN YNLDCLGNGR TVCHCGADNC SGFLGVRPKS
1310 1320 1330 1340 1350
ACTSAVDEKT KNAKLKKRRK VKAEAKPIHE DYCFQCGDGG ELVMCDKKDC
1360 1370 1380 1390 1400
PKAYHLLCLN LTQPPHGKWE CPWHRCDECG SVAVSFCEFC PHSFCKAHGK
1410 1420 1430 1440
GALVPSALEG RLCCSSHDPA SPVSPEYWSK IRCKWESQDS GEEVKE
Length:1,446
Mass (Da):161,649
Last modified:April 20, 2010 - v1
Checksum:i7AD4541DBCC619C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156990 Genomic DNA. No translation available.
RefSeqiNP_001074738.1. NM_001081269.1.
XP_006509163.1. XM_006509100.1.
XP_006509164.1. XM_006509101.1.
UniGeneiMm.217337.

Genome annotation databases

EnsembliENSMUST00000084026; ENSMUSP00000081040; ENSMUSG00000054823.
ENSMUST00000142395; ENSMUSP00000117778; ENSMUSG00000054823.
GeneIDi234135.
KEGGimmu:234135.
UCSCiuc009lgn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156990 Genomic DNA. No translation available.
RefSeqiNP_001074738.1. NM_001081269.1.
XP_006509163.1. XM_006509100.1.
XP_006509164.1. XM_006509101.1.
UniGeneiMm.217337.

3D structure databases

ProteinModelPortaliD3Z357.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi234135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084026; ENSMUSP00000081040; ENSMUSG00000054823.
ENSMUST00000142395; ENSMUSP00000117778; ENSMUSG00000054823.
GeneIDi234135.
KEGGimmu:234135.
UCSCiuc009lgn.1. mouse.

Organism-specific databases

CTDi54904.
MGIiMGI:2142581. Whsc1l1.

Phylogenomic databases

GeneTreeiENSGT00780000121845.
HOGENOMiHOG000230893.
KOiK11425.
OMAiMEKDIHK.

Miscellaneous databases

ChiTaRSiWhsc1l1. mouse.
NextBioi382034.
SOURCEiSearch...

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 3 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z357_MOUSE
AccessioniPrimary (citable) accession number: D3Z357
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.