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D3Z357

- D3Z357_MOUSE

UniProt

D3Z357 - D3Z357_MOUSE

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Protein
Submitted name:

Histone-lysine N-methyltransferase NSD3

Gene
Whsc1l1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotations

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: Ensembl
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferase NSD3Imported
Gene namesi
Name:Whsc1l1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2142581. Whsc1l1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000114921.
HOGENOMiHOG000230893.
KOiK11425.
OMAiMEKDIHK.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 3 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3Z357-1 [UniParc]FASTAAdd to Basket

« Hide

MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNHSDI VEDGGPTPFE     50
ATLQQGFQYP PTTEDLPPLT NGYPPSISLY ETQTKYPPYN QYPNGSANGF 100
GAVRNFSPTD YYHSEIPNTR PHEILEKPSP PQPPPLPPPP PPPPPPPSVP 150
QTVIPKKTGS PEIKLKITKT IQNGRELFES SLCGDLLNEV QASEHTKSKH 200
ESRKEKRKKS NRHESSRSEE RRSHKIPKLE PEGQNRPNER VDTAPEKPRE 250
EPVLKEAIPV QPILSSVPTT ETSTGVKFQV GDLVWSKVGT YPWWPCMVSS 300
DPQLEVHSKI NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHEQYEELL 350
AEAAKQASNH SEKQKIRKPR PQRERAQWDI GIAHAEKALK MTREERVEQY 400
TFIYIDKQPE EASSQAKKNV TSKTEVKKPR RPRSVLNSQP EQTNAGEVAS 450
SQSSTDLRRQ SQRRHTSLEE EEPPPVKIAW KTAAARKSLP ASITMHKGSL 500
DLQKCNMSPV VKIEQVFALQ NATGDGKFID QFVYSTKGIG NKTEISVRGQ 550
DRLIISSPSQ RSEKPAQSAS SPEATSGSAG PVEKKQQRRS IRTRSESEKS 600
AEVVPKKKIK KEQVETAPQA SLKTGLQKGA SEISDSCKPL KKRSRASTDV 650
ETASCTYRDT SDSDSRGLSD GQVGFGKQVD SPSATADADA SDAQSVDSSL 700
SRRGVGTSKK DTVCQVCEKA GDCLVACEGE CCRHFHVECL GLTAVPEGHF 750
TCEECETGQH PCFSCKVSGK DVKRCSVSVC GKFYHEACVR KFPTAIFESK 800
GFRCPQHCCS SCSMEKDIHK ASKGRMMRCL RCPVAYHVGD ACVAAGSVSV 850
SSHILICSNH SKRSSQSAAI NVGFCFVCAR GLIVQDHSDP MFSSYAYKSH 900
YLLSESNRAE LMKLPMIPSS SASKKRCEKG GRLLCCESCP ASFHPECLSI 950
DMPEGCWNCN DCKAGKKLHY KQIVWVKLGN YRWWPAEICS PRSVPLNIQG 1000
LKHDLGDFPV FFFGSHDYYW VHQGRVFPYV EGDKHFAEGQ TSINKTFKKA 1050
LEEAAKRFQE LKAQRESKEA LEMERTSRKP PPYKHIKANK VIGKVQVQVA 1100
DLSEIPRCNC KPGDENPCGL ESQCLNRMSQ YECHPQVCPA GDRCQNQCFT 1150
KRLYPDAEVI KTERRGWGLR TKRSIKKGEF VNEYVGELID EEECRLRIKR 1200
AHENSVTNFY MLTVTKDRII DAGPKGNYSR FMNHSCNPNC ETQKWTVNGD 1250
VRVGLFALCD IPAGMELTFN YNLDCLGNGR TVCHCGADNC SGFLGVRPKS 1300
ACTSAVDEKT KNAKLKKRRK VKAEAKPIHE DYCFQCGDGG ELVMCDKKDC 1350
PKAYHLLCLN LTQPPHGKWE CPWHRCDECG SVAVSFCEFC PHSFCKAHGK 1400
GALVPSALEG RLCCSSHDPA SPVSPEYWSK IRCKWESQDS GEEVKE 1446
Length:1,446
Mass (Da):161,649
Last modified:April 20, 2010 - v1
Checksum:i7AD4541DBCC619C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC156990 Genomic DNA. No translation available.
RefSeqiNP_001074738.1. NM_001081269.1.
XP_006509163.1. XM_006509100.1.
XP_006509164.1. XM_006509101.1.
UniGeneiMm.217337.

Genome annotation databases

EnsembliENSMUST00000084026; ENSMUSP00000081040; ENSMUSG00000054823.
ENSMUST00000142395; ENSMUSP00000117778; ENSMUSG00000054823.
GeneIDi234135.
KEGGimmu:234135.
UCSCiuc009lgn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC156990 Genomic DNA. No translation available.
RefSeqi NP_001074738.1. NM_001081269.1.
XP_006509163.1. XM_006509100.1.
XP_006509164.1. XM_006509101.1.
UniGenei Mm.217337.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 234135.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084026 ; ENSMUSP00000081040 ; ENSMUSG00000054823 .
ENSMUST00000142395 ; ENSMUSP00000117778 ; ENSMUSG00000054823 .
GeneIDi 234135.
KEGGi mmu:234135.
UCSCi uc009lgn.1. mouse.

Organism-specific databases

CTDi 54904.
MGIi MGI:2142581. Whsc1l1.

Phylogenomic databases

GeneTreei ENSGT00740000114921.
HOGENOMi HOG000230893.
KOi K11425.
OMAi MEKDIHK.

Miscellaneous databases

ChiTaRSi WHSC1L1. mouse.
NextBioi 382034.
SOURCEi Search...

Family and domain databases

Gene3Di 3.30.40.10. 3 hits.
InterProi IPR006560. AWS.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 3 hits.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiD3Z357_MOUSE
AccessioniPrimary (citable) accession number: D3Z357
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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