ID   D3Z314_MOUSE            Unreviewed;       170 AA.
AC   D3Z314;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   SubName: Full=Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 {ECO:0000313|Ensembl:ENSMUSP00000119056.2};
DE   Flags: Fragment;
GN   Name=Slc11a2 {ECO:0000313|Ensembl:ENSMUSP00000119056.2,
GN   ECO:0000313|MGI:MGI:1345279};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119056.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000119056.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119056.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000119056.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119056.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004107}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004155}.
CC   -!- SIMILARITY: Belongs to the NRAMP family.
CC       {ECO:0000256|ARBA:ARBA00006670}.
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DR   AlphaFoldDB; D3Z314; -.
DR   SMR; D3Z314; -.
DR   SwissPalm; D3Z314; -.
DR   jPOST; D3Z314; -.
DR   MaxQB; D3Z314; -.
DR   PeptideAtlas; D3Z314; -.
DR   ProteomicsDB; 306142; -.
DR   Antibodypedia; 26282; 409 antibodies from 31 providers.
DR   Ensembl; ENSMUST00000123461.8; ENSMUSP00000119056.2; ENSMUSG00000023030.17.
DR   AGR; MGI:1345279; -.
DR   MGI; MGI:1345279; Slc11a2.
DR   VEuPathDB; HostDB:ENSMUSG00000023030; -.
DR   GeneTree; ENSGT00940000155330; -.
DR   HOGENOM; CLU_1574315_0_0_1; -.
DR   OMA; AFHFNGH; -.
DR   ChiTaRS; Slc11a2; mouse.
DR   Proteomes; UP000000589; Chromosome 15.
DR   Bgee; ENSMUSG00000023030; Expressed in epithelium of small intestine and 246 other cell types or tissues.
DR   ExpressionAtlas; D3Z314; baseline and differential.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046915; F:transition metal ion transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001046; NRAMP_fam.
DR   NCBIfam; NF037982; Nramp_1; 1.
DR   PANTHER; PTHR11706:SF40; NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2; 1.
DR   PANTHER; PTHR11706; SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER; 1.
DR   Pfam; PF01566; Nramp; 1.
PE   1: Evidence at protein level;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022496};
KW   Iron {ECO:0000256|ARBA:ARBA00022496};
KW   Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:D3Z314,
KW   ECO:0007829|MaxQB:D3Z314};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022496}.
FT   TRANSMEM        97..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         170
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000119056.2"
SQ   SEQUENCE   170 AA;  18480 MW;  94F283415217A7DD CRC64;
     MVLDPKEKMP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY FDEKIPIPEE
     EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR
     LAARLGVVTG LHLAEVCHRQ YPKVPRIILW LMVELAIIGS DMQEVIGSAI
//