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Protein
Submitted name:

Natural resistance-associated macrophage protein 2

Gene

Slc11a2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • cadmium ion transmembrane transport Source: MGI
  • cation transmembrane transport Source: MGI
  • cellular copper ion homeostasis Source: Ensembl
  • cellular response to hypoxia Source: Ensembl
  • cellular response to iron ion Source: Ensembl
  • cellular response to oxidative stress Source: MGI
  • cellular response to tumor necrosis factor Source: Ensembl
  • cobalt ion transport Source: MGI
  • copper ion import into cell Source: Ensembl
  • copper ion transmembrane transport Source: MGI
  • copper ion transport Source: MGI
  • dendrite morphogenesis Source: MGI
  • detection of oxygen Source: Ensembl
  • erythrocyte development Source: MGI
  • ferrous iron import Source: MGI
  • ferrous iron transmembrane transport Source: MGI
  • ferrous iron transport Source: MGI
  • heme biosynthetic process Source: MGI
  • hydrogen ion transmembrane transport Source: GOC
  • iron ion transport Source: MGI
  • lead ion transport Source: MGI
  • learning or memory Source: MGI
  • manganese ion transmembrane transport Source: MGI
  • manganese ion transport Source: MGI
  • multicellular organismal iron ion homeostasis Source: MGI
  • nickel cation transmembrane transport Source: MGI
  • nickel cation transport Source: MGI
  • porphyrin-containing compound biosynthetic process Source: MGI
  • porphyrin-containing compound metabolic process Source: MGI
  • proton transport Source: MGI
  • response to cadmium ion Source: Ensembl
  • response to lead ion Source: Ensembl
  • response to manganese ion Source: Ensembl
  • vanadium ion transport Source: MGI
  • zinc II ion transmembrane transport Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Natural resistance-associated macrophage protein 2Imported
Gene namesi
Name:Slc11a2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1345279. Slc11a2.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: MGI
  • apical plasma membrane Source: MGI
  • basal part of cell Source: MGI
  • brush border Source: MGI
  • cell surface Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic vesicle Source: MGI
  • early endosome Source: MGI
  • endomembrane system Source: MGI
  • endosome Source: MGI
  • integral component of plasma membrane Source: MGI
  • late endosome Source: MGI
  • late endosome membrane Source: MGI
  • lysosomal membrane Source: MGI
  • lysosome Source: MGI
  • membrane Source: MGI
  • nucleus Source: MGI
  • paraferritin complex Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: MGI
  • recycling endosome Source: MGI
  • trans-Golgi network Source: MGI
  • vacuole Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD3Z314.
ExpressionAtlasiD3Z314. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023774.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000006526.
HOGENOMiHOG000152203.

Family and domain databases

InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3Z314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLDPKEKMP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY
60 70 80 90 100
FDEKIPIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA
110 120 130 140 150
GFKLLWVLLL ATIVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRIILW
160 170
LMVELAIIGS DMQEVIGSAI
Length:170
Mass (Da):18,480
Last modified:April 20, 2010 - v1
Checksum:i94F283415217A7DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei170 – 1701Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139571 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000123461; ENSMUSP00000119056; ENSMUSG00000023030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139571 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000123461; ENSMUSP00000119056; ENSMUSG00000023030.

Organism-specific databases

MGIiMGI:1345279. Slc11a2.

Phylogenomic databases

GeneTreeiENSGT00390000006526.
HOGENOMiHOG000152203.

Miscellaneous databases

ChiTaRSiSlc11a2. mouse.
NextBioi35550665.
SOURCEiSearch...

Gene expression databases

BgeeiD3Z314.
ExpressionAtlasiD3Z314. baseline and differential.

Family and domain databases

InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z314_MOUSE
AccessioniPrimary (citable) accession number: D3Z314
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 24, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.