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Protein
Submitted name:

Natural resistance-associated macrophage protein 2

Gene

Slc11a2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. cadmium ion binding Source: Ensembl
  2. cadmium ion transmembrane transporter activity Source: MGI
  3. cobalt ion binding Source: Ensembl
  4. cobalt ion transmembrane transporter activity Source: MGI
  5. copper ion binding Source: Ensembl
  6. copper ion transmembrane transporter activity Source: MGI
  7. ferrous iron transmembrane transporter activity Source: MGI
  8. hydrogen ion transmembrane transporter activity Source: MGI
  9. inorganic cation transmembrane transporter activity Source: MGI
  10. iron ion binding Source: Ensembl
  11. iron ion transmembrane transporter activity Source: MGI
  12. lead ion transmembrane transporter activity Source: MGI
  13. manganese ion binding Source: Ensembl
  14. manganese ion transmembrane transporter activity Source: MGI
  15. nickel cation binding Source: Ensembl
  16. nickel cation transmembrane transporter activity Source: MGI
  17. solute:proton symporter activity Source: MGI
  18. vanadium ion transmembrane transporter activity Source: MGI
  19. zinc ion binding Source: Ensembl
  20. zinc ion transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. cadmium ion transmembrane transport Source: MGI
  3. cation transmembrane transport Source: MGI
  4. cellular copper ion homeostasis Source: Ensembl
  5. cellular response to hypoxia Source: Ensembl
  6. cellular response to iron ion Source: Ensembl
  7. cellular response to oxidative stress Source: MGI
  8. cellular response to tumor necrosis factor Source: Ensembl
  9. cobalt ion transport Source: MGI
  10. copper ion import into cell Source: Ensembl
  11. copper ion transmembrane transport Source: MGI
  12. copper ion transport Source: MGI
  13. dendrite morphogenesis Source: MGI
  14. detection of oxygen Source: Ensembl
  15. erythrocyte development Source: MGI
  16. ferrous iron import Source: MGI
  17. ferrous iron transmembrane transport Source: GOC
  18. ferrous iron transport Source: MGI
  19. heme biosynthetic process Source: MGI
  20. hydrogen ion transmembrane transport Source: GOC
  21. iron ion transmembrane transport Source: GOC
  22. iron ion transport Source: MGI
  23. lead ion transport Source: MGI
  24. learning or memory Source: MGI
  25. manganese ion transmembrane transport Source: MGI
  26. manganese ion transport Source: MGI
  27. multicellular organismal iron ion homeostasis Source: MGI
  28. nickel cation transmembrane transport Source: MGI
  29. nickel cation transport Source: MGI
  30. porphyrin-containing compound biosynthetic process Source: MGI
  31. porphyrin-containing compound metabolic process Source: MGI
  32. proton transport Source: MGI
  33. response to cadmium ion Source: Ensembl
  34. response to lead ion Source: Ensembl
  35. response to manganese ion Source: Ensembl
  36. vanadium ion transport Source: MGI
  37. zinc II ion transmembrane transport Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Natural resistance-associated macrophage protein 2Imported
Gene namesi
Name:Slc11a2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1345279. Slc11a2.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: MGI
  2. apical plasma membrane Source: MGI
  3. basal part of cell Source: MGI
  4. brush border Source: MGI
  5. cell surface Source: MGI
  6. cytoplasm Source: MGI
  7. cytoplasmic vesicle Source: MGI
  8. early endosome Source: MGI
  9. endomembrane system Source: MGI
  10. endosome Source: MGI
  11. integral component of plasma membrane Source: MGI
  12. late endosome Source: MGI
  13. late endosome membrane Source: MGI
  14. lysosomal membrane Source: MGI
  15. lysosome Source: MGI
  16. membrane Source: MGI
  17. nucleus Source: MGI
  18. paraferritin complex Source: MGI
  19. perinuclear region of cytoplasm Source: MGI
  20. plasma membrane Source: MGI
  21. recycling endosome Source: MGI
  22. trans-Golgi network Source: MGI
  23. vacuole Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD3Z314.
ExpressionAtlasiD3Z314. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000006526.
HOGENOMiHOG000152203.

Family and domain databases

InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3Z314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLDPKEKMP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY
60 70 80 90 100
FDEKIPIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA
110 120 130 140 150
GFKLLWVLLL ATIVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRIILW
160 170
LMVELAIIGS DMQEVIGSAI
Length:170
Mass (Da):18,480
Last modified:April 20, 2010 - v1
Checksum:i94F283415217A7DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei170 – 1701Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139571 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000123461; ENSMUSP00000119056; ENSMUSG00000023030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139571 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000123461; ENSMUSP00000119056; ENSMUSG00000023030.

Organism-specific databases

MGIiMGI:1345279. Slc11a2.

Phylogenomic databases

GeneTreeiENSGT00390000006526.
HOGENOMiHOG000152203.

Miscellaneous databases

ChiTaRSiSlc11a2. mouse.
NextBioi35550665.
SOURCEiSearch...

Gene expression databases

BgeeiD3Z314.
ExpressionAtlasiD3Z314. baseline and differential.

Family and domain databases

InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD3Z314_MOUSE
AccessioniPrimary (citable) accession number: D3Z314
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 29, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.