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D3Z314

- D3Z314_MOUSE

UniProt

D3Z314 - D3Z314_MOUSE

Protein
Submitted name:

Natural resistance-associated macrophage protein 2

Gene

Slc11a2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cadmium ion binding Source: Ensembl
    2. cadmium ion transmembrane transporter activity Source: Ensembl
    3. cobalt ion binding Source: Ensembl
    4. cobalt ion transmembrane transporter activity Source: MGI
    5. copper ion binding Source: Ensembl
    6. copper ion transmembrane transporter activity Source: Ensembl
    7. ferrous iron transmembrane transporter activity Source: MGI
    8. hydrogen ion transmembrane transporter activity Source: MGI
    9. iron ion binding Source: Ensembl
    10. iron ion transmembrane transporter activity Source: MGI
    11. lead ion transmembrane transporter activity Source: Ensembl
    12. manganese ion binding Source: Ensembl
    13. manganese ion transmembrane transporter activity Source: Ensembl
    14. nickel cation binding Source: Ensembl
    15. nickel cation transmembrane transporter activity Source: Ensembl
    16. solute:proton symporter activity Source: Ensembl
    17. vanadium ion transmembrane transporter activity Source: Ensembl
    18. zinc ion binding Source: Ensembl
    19. zinc ion transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. cellular response to hypoxia Source: Ensembl
    3. cellular response to iron ion Source: Ensembl
    4. cellular response to oxidative stress Source: Ensembl
    5. cellular response to tumor necrosis factor Source: Ensembl
    6. cobalt ion transport Source: MGI
    7. dendrite morphogenesis Source: MGI
    8. detection of oxygen Source: Ensembl
    9. erythrocyte development Source: MGI
    10. ferrous iron import Source: MGI
    11. ferrous iron transport Source: MGI
    12. heme biosynthetic process Source: MGI
    13. hydrogen ion transmembrane transport Source: GOC
    14. iron ion transport Source: MGI
    15. learning or memory Source: MGI
    16. multicellular organismal iron ion homeostasis Source: MGI
    17. porphyrin-containing compound biosynthetic process Source: MGI
    18. porphyrin-containing compound metabolic process Source: MGI
    19. proton transport Source: MGI
    20. response to cadmium ion Source: Ensembl
    21. response to lead ion Source: Ensembl
    22. response to manganese ion Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Natural resistance-associated macrophage protein 2Imported
    Gene namesi
    Name:Slc11a2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1345279. Slc11a2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basal part of cell Source: Ensembl
    3. brush border Source: MGI
    4. cell surface Source: MGI
    5. cytoplasmic vesicle Source: Ensembl
    6. early endosome Source: MGI
    7. endomembrane system Source: MGI
    8. endosome Source: MGI
    9. integral component of plasma membrane Source: MGI
    10. late endosome membrane Source: Ensembl
    11. lysosomal membrane Source: Ensembl
    12. nucleus Source: Ensembl
    13. paraferritin complex Source: Ensembl
    14. perinuclear region of cytoplasm Source: Ensembl
    15. plasma membrane Source: MGI
    16. recycling endosome Source: MGI
    17. trans-Golgi network Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiD3Z314.
    BgeeiD3Z314.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000006526.
    HOGENOMiHOG000152203.

    Family and domain databases

    InterProiIPR001046. NRAMP_fam.
    [Graphical view]
    PANTHERiPTHR11706. PTHR11706. 1 hit.
    PfamiPF01566. Nramp. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D3Z314-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLDPKEKMP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY    50
    FDEKIPIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA 100
    GFKLLWVLLL ATIVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRIILW 150
    LMVELAIIGS DMQEVIGSAI 170
    Length:170
    Mass (Da):18,480
    Last modified:April 20, 2010 - v1
    Checksum:i94F283415217A7DD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei170 – 1701Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC139571 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000123461; ENSMUSP00000119056; ENSMUSG00000023030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC139571 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000123461 ; ENSMUSP00000119056 ; ENSMUSG00000023030 .

    Organism-specific databases

    MGIi MGI:1345279. Slc11a2.

    Phylogenomic databases

    GeneTreei ENSGT00390000006526.
    HOGENOMi HOG000152203.

    Miscellaneous databases

    ChiTaRSi SLC11A2. mouse.
    NextBioi 35550665.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi D3Z314.
    Bgeei D3Z314.

    Family and domain databases

    InterProi IPR001046. NRAMP_fam.
    [Graphical view ]
    PANTHERi PTHR11706. PTHR11706. 1 hit.
    Pfami PF01566. Nramp. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiD3Z314_MOUSE
    AccessioniPrimary (citable) accession number: D3Z314
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3