ID D3Z2I8_MOUSE Unreviewed; 262 AA. AC D3Z2I8; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 27-MAR-2024, entry version 85. DE SubName: Full=Src homology 2 domain-containing transforming protein C1 {ECO:0000313|Ensembl:ENSMUSP00000119293.2}; DE Flags: Fragment; GN Name=Shc1 {ECO:0000313|Ensembl:ENSMUSP00000119293.2, GN ECO:0000313|MGI:MGI:98296}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119293.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0007829|PubMed:15592455} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=15592455; DOI=10.1038/nbt1046; RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., RA Zha X.M., Polakiewicz R.D., Comb M.J.; RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."; RL Nat. Biotechnol. 23:94-101(2005). RN [2] {ECO:0007829|PubMed:19144319} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006; RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M., RA Thibault P.; RT "The phagosomal proteome in interferon-gamma-activated macrophages."; RL Immunity 30:143-154(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000119293.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119293.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [5] {ECO:0007829|PubMed:23806337} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001; RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.; RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic RT pathways."; RL Mol. Cell 50:919-930(2013). RN [6] {ECO:0000313|Ensembl:ENSMUSP00000119293.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119293.2}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; D3Z2I8; -. DR SMR; D3Z2I8; -. DR jPOST; D3Z2I8; -. DR MaxQB; D3Z2I8; -. DR PeptideAtlas; D3Z2I8; -. DR ProteomicsDB; 314747; -. DR Antibodypedia; 731; 1348 antibodies from 45 providers. DR Ensembl; ENSMUST00000128238.8; ENSMUSP00000119293.2; ENSMUSG00000042626.14. DR AGR; MGI:98296; -. DR MGI; MGI:98296; Shc1. DR VEuPathDB; HostDB:ENSMUSG00000042626; -. DR GeneTree; ENSGT00950000182870; -. DR HOGENOM; CLU_029532_1_0_1; -. DR ChiTaRS; Shc1; mouse. DR Proteomes; UP000000589; Chromosome 3. DR Bgee; ENSMUSG00000042626; Expressed in lens of camera-type eye and 66 other cell types or tissues. DR ExpressionAtlas; D3Z2I8; baseline and differential. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR CDD; cd01209; PTB_Shc; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR006019; PID_Shc-like. DR InterPro; IPR006020; PTB/PI_dom. DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1. DR PANTHER; PTHR10337:SF2; SHC-TRANSFORMING PROTEIN 1; 1. DR Pfam; PF00640; PID; 1. DR PRINTS; PR00629; SHCPIDOMAIN. DR SMART; SM00462; PTB; 1. DR SUPFAM; SSF50729; PH domain-like; 1. DR PROSITE; PS01179; PID; 1. PE 1: Evidence at protein level; KW Growth regulation {ECO:0000256|ARBA:ARBA00022604}; KW Proteomics identification {ECO:0007829|EPD:D3Z2I8, KW ECO:0007829|MaxQB:D3Z2I8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 46..211 FT /note="PID" FT /evidence="ECO:0000259|PROSITE:PS01179" FT REGION 1..26 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 209..229 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 242..262 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 262 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000119293.2" SQ SEQUENCE 262 AA; 28759 MW; 072C22B140195778 CRC64; MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ DTAEYVAYVA KDPVNQRACH ILECPEGLAQ DVISTIGQAF ELRFKQYLRN PPKLVTPHDR MAGFDGSAWD EEEEEPPDHQ YYNDFPGKEP PLGGVVDMRL REGAARPTLP SAQMSSHLGA TL //